Eruptive keratoacanthoma with an internal malignant neoplasm

Assaf

et al. 2013

Acad Dermatol Venereol

Generalized eruptive keratoacanthoma (GEKA) of Grzybowski is a sporadically occurring, extremely rare variant of keratoacanthoma characterized clinically by severely pruritic, generalized eruption of numerous small follicular papules, often with a central keratotic plug, and histologically by typical features of solitary keratoacanthoma. Despite the continuous addition of new case reports, no definite diagnostic criteria have been established, and an optimum treatment is not yet determined. Herein, we review the different aspects of this rare entity, including pathogenesis, clinical and histopathological features, differential diagnosis, course and prognosis. Different therapeutic approaches and their impact on the course and prognosis of the disease are also evaluated and presented. We propose two sets of diagnostic criteria to define the disease more precisely and to avoid overlapping and confusion with other types of multiple keratoacanthoma. The first set comprises constant clinical and histopathological features that almost always present in every case and the second set includes variable features that were reported in some patients, and to which any emerging finding could be added to avoid missing cases. Although different therapeutic options have been used, either as single agents or in combinations, there is no standard therapy for GEKA and the disease still represents a therapeutic challenge.

Section: Pathogenesismentioning

confidence: 99%

Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation

Assaf

et al. 2013

Acad Dermatol Venereol

The Journal of Dermatology

“…Several associated conditions have been reported consisting of autoimmune diseases (Sj€ ogren's syndrome, 6 systemic lupus erythematosus) 7 and internal malignancies (asymptomatic ovarian carcinoma, 8 metastasizing carcinoma of the fallopian tube, stem cell leukemia, metastatic colon cancer). 9 So far, the present case is the first report in the published work about GEKA with vitiligo, which reveals that immunity may play an important role in GEKA.…”

Section: Discussionmentioning

confidence: 99%

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Zhang

et al. 2017

Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1-year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN.

“…Other reports link internal ma lignancy with the appearance of keratoacanthomas. in the absence of sebaceous neoplasms [29][30][31][32][33]. One patient with intestinal polyps and a markedly positive family history of colon cancer developed sebaceous adenomas and a keratoacanthoma following iatrogenic immunosuppres- sion.…”

Section: Discussionmentioning

confidence: 99%

“…17 (43%) had at least one keratoacanthoma (table I). Several cases of keratoacanthoma in associ ation with visceral malignancy, but without the presence of sebaceous adenoma, have also been reported [29][30][31][32][33]. The association of both keratoacanthomas and sebaceous neoplasms in this syndrome may be explained by their common derivation from pilosebaceous follicles [36].…”

Section: Discussionmentioning

confidence: 99%

The Muir-Torre Syndrome: A Disease of Sebaceous and Colonic Neoplasms

Schwartz

Goldberg²,

Mahmood³

et al. 1989

Dermatology

The Muir-Torre syndrome of sebaceous neoplasms of the skin, with or without keratoacanthomas, and multiple low-grade visceral malignancies with prolonged survival is a rare disorder. Colonic polyps are frequently present, and the syndrome appears to be familial. We report 2 unrelated patients with the Muir-Torre syndrome. Each case exhibited sebaceous adenomas. Gastrointestinal findings included colonic adenocarcinomas and a tubulovillous adenoma. Although an unusual disease, the Muir-Torre syndrome requires recognition because these patients are at risk for multiple primary malignancies and may have family members also at risk.