ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly

Ubags, Niki; Baker, Jonathan; Boots, Agnes W.; Costa, Rita; El-Merhie, Natalia; Fabre, Aurélie; Faiz, Alen; Heijink, Irene H.; Hiemstra, Pieter S.; Lehmann, Mareike; Meiners, Silke; Enes, Sara Rolandsson; Bartel, Sabine

doi:10.1183/23120541.00350-2019

Cited by 2 publications

(1 citation statement)

References 82 publications

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“…Указанные изменения подтверждают роль метаболического перепрограммирования АМ при воспалении, инициированном сигаретным дымом. Кроме того, при моделировании ХОБЛ в CD11B + АМ наблюдается увеличение массы митохондрий, что указывает либо на потенциальное присутствие дефектной митофагии, либо на процессы избыточной митофузии или слияния митохондрий [51].…”

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Cellular metabolism and mitochondrial dysfunction in chronic obstructive pulmonary disease

Невзорова

Brodskaya

Плехова

et al. 2023

Pulʹmonologiâ (Mosk.)

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Chronic obstructive pulmonary disease (COPD) is considered a typical model of accelerated aging due to the variability and systemic nature of its manifestations. The leading factor in tissue remodeling in COPD is a change or reprogramming of the cellular metabolism in response to external factors such as tobacco combustion products, biofuels, viruses, etc. Mitochondrial biology dominates the spectrum of mechanisms of tissue and cellular reprogramming in COPD. Being parasymbiotic organelles, mitochondria have a complex system of interaction with other cells of the human body and participate in both biogenesis, or formation of new organelles, and mitophagy, or elimination of defective mitochondria by the host cell. Both of these mechanisms are dysregulated in COPD.The aim of this work is to combine the accumulated research experience in the field of cellular metabolism and the role of mitochondria for in-depth COPD phenotyping depending on the metabolic reprogramming variants and for development of new therapeutic possibilities to correct the reprogramming.Conclusion. Mitochondria are key regulators of metabolism, redox homeostasis, cell survival and proliferation. These processes are controlled by various intra- and intercellular signaling pathways and reflect the COPD-associated imbalance at the level of various tissue lineages: alveolocytes, epithelial cells of the lung tissue, smooth myocytes of the respiratory tract, alveolar macrophages, striated muscle cells, mesenchymal stromal cells, progenitor cells, etc. The studies of metabolome and mitochondrial function pointed out where to look for new therapeutic options for COPD.

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Cellular metabolism and mitochondrial dysfunction in chronic obstructive pulmonary disease

Невзорова

Brodskaya

Плехова

et al. 2023

Pulʹmonologiâ (Mosk.)

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ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

Reddy,

Bizymi,

Schweikert

et al. 2023

ERJ Open Res

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In this article, early career members of the Assembly 3: Basic and Translational Sciences of the European Respiratory Society summarise the key messages discussed during six selected sessions that took place at the ERS congress 2023 in Milan, Italy. Aligned with the theme of the congress, the first topic covered is “micro- and macro-environments and respiratory health”, followed by a summary of the “Scientific year in review” session. Next, recent advances in experimental methodologies and new technologies were highlighted within the “tissue modelling and remodelling” session, as well as summary of the translational science session, “what did you always want to know about omics analyses for clinical practice?”, organised as part of the ERS Translational Science Working group's aims. Details on how the next-generation sequencing can be integrated with laboratory methods were provided in the “lost in translation: new insights into cell-to-cell crosstalk in lung disease” session and a final summary of studies presented in the “from the transcriptome landscape to innovative preclinical models in lung diseases” session linking the transcriptome landscape with innovative preclinical models was included in this review. The wide range of topics covered in the selected sessions and the high quality of the research discussed highlight the strength of the basic and translational science being presented at the international respiratory conference organised by the ERS.

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ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly

Cited by 2 publications

References 82 publications

Cellular metabolism and mitochondrial dysfunction in chronic obstructive pulmonary disease

Cellular metabolism and mitochondrial dysfunction in chronic obstructive pulmonary disease

ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly

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