Erratum to: Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin

Szlávicz, Eszter; Szabó, Kornélia; Groma, Gergely; Bata-Csorgo, Zsuzsanna; Pagani, Franco; Kemény, Lajos; Széll, Márta

doi:10.1007/s11010-017-3105-y

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“…The expression of fibronectin (FN) isoforms, including extra domain A (EDA), has been reported to be overexpressed in psoriatic uninvolved epidermis sensitizes keratinocytes to mitogenic signals [ 73 ]. Hacats—immortalized keratinocyte cell lines—expressed a higher ratio of EDA + mRNA and EDA + isoform of fibronectin [ 74 ].…”

Section: Alternative Splicing Variants: Psoriasis Isoformsmentioning

confidence: 99%

Transcriptional Basis of Psoriasis from Large Scale Gene Expression Studies: The Importance of Moving towards a Precision Medicine Approach

Krishnan

Kõks

2022

IJMS

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Transcriptome profiling techniques, such as microarrays and RNA sequencing (RNA-seq), are valuable tools for deciphering the regulatory network underlying psoriasis and have revealed large number of differentially expressed genes in lesional and non-lesional skin. Such approaches provide a more precise measurement of transcript levels and their isoforms than any other methods. Large cohort transcriptomic analyses have greatly improved our understanding of the physiological and molecular mechanisms underlying disease pathogenesis and progression. Here, we mostly review the findings of some important large scale psoriatic transcriptomic studies, and the benefits of such studies in elucidating potential therapeutic targets and biomarkers for psoriasis treatment. We also emphasised the importance of looking into the alternatively spliced RNA isoforms/transcripts in psoriasis, rather than focussing only on the gene-level annotation. The neutrophil and blood transcriptome signature in psoriasis is also briefly reviewed, as it provides the immune status information of patients and is a less invasive platform. The application of precision medicine in current management of psoriasis, by combining transcriptomic data, improves the clinical response outcome in individual patients. Drugs tailored to individual patient’s genetic profile will greatly improve patient outcome and cost savings for the healthcare system.

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Section: Alternative Splicing Variants: Psoriasis Isoformsmentioning

confidence: 99%

Transcriptional Basis of Psoriasis from Large Scale Gene Expression Studies: The Importance of Moving towards a Precision Medicine Approach

Krishnan

Kõks

2022

IJMS

View full text Add to dashboard Cite

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Erratum to: Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin

Abstract: The original article was published with error in an abstract. The word ''facwwtors'' in the seventh sentence should read as ''factors''.The online version of the original article can be found under

Cited by 1 publication

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Transcriptional Basis of Psoriasis from Large Scale Gene Expression Studies: The Importance of Moving towards a Precision Medicine Approach

Transcriptional Basis of Psoriasis from Large Scale Gene Expression Studies: The Importance of Moving towards a Precision Medicine Approach

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