Erratum to “Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistin” [Diagn Microbiol Infect Dis 65 (2009) 188–191]

Rodríguez, Carlos Hernán; Bombicino, Karina; Granados, Gabriela; Nastro, Marcela; Vay, Carlos; Famiglietti, Ángela

doi:10.1016/j.diagmicrobio.2009.12.015

Cited by 19 publications

(20 citation statements)

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“…Hawley et al [4] detected 100% heteroresistance among 21 patients in the United States. Later, in their studies in Argentine, Rodriguez et al [19] Rodriguez et al [20] have found 46% and 43% heteroresistance rates in 2009 and 2010, respectively. In their case report, Moosavian et al [10] have recently demonstrated post neurosurgical meningitis due to colistin heteroresistant A. baumannii.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains

Gazel¹,

Otkun²

2018

mjima

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Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported. In this study we aimed to investigate the colistin heteroresistance rates and the effects of colistin and its combinations on colistin heteroresistance/resistance development in CR-ABC strains in our hospital. Materials and Methods: Heteroresistance analysis was performed on CR-ABC isolates and standard ABC strain [American Type Culture Collection (ATCC) 19606)] strain. To investigate hidden heteroresistance, the isolates were exposed to colistin at sub-inhibitory concentrations. 'Time-kill' study was performed on the standard strain and a clinical strain for colistin. Serial passage test was performed to investigate the effects of drug combinations on heteroresistance/resistance development. Results: In the first heteroresistance analysis test, all strains were found to be non-heteroresistant. However, after sub-inhibitory exposure to colistin, colistin heteroresistance/resistance developed in all isolates. In serial passages, colistin-rifampicin and colistin-tigecycline (Col+Tig) combinations were found to be effective and prevented growth of colistin-resistant sub-populations even at sub-inhibitory doses. Colistin-gentamicin (Col+Gen) combination was not found to be effective against the clinical isolate while it was effective on ATCC strain. Colistin-fluconazole combination was found to be ineffective at all concentrations. Conclusion: In our study, it was shown that the strains which were detected to be non-heteroresistant could easily transform to heteroresistant/ resistant forms after exposure to colistin. Colistin-rifampicin and Col+Tig combinations were found to be effective and prevented the emergence of heteroresistance/resistance to colistin even at low concentrations. At low concentrations, Col+Gen combination was ineffective against the clinical ABC isolate. Colistin-fluconazole combination failed to inhibit the emergence of resistant bacteria. Heteroresistance or resistance to colistin may easily develop because of inappropriate use of this antibiotic. To prevent this condition, colistin should be administrated at appropriate doses and in combination with the suggested antibiotics. Keywords: Colistin, carbapenem, combination, heteroresistance, rifampin Giriş: Kolistin, karbapenem dirençli Acinetobacter baumannii kompleks (CR-ABC) enfeksiyonu olan hastalarda kullanılabilecek seçeneklerdendir, ancak son zamanlarda kolistin için de direnç ve heterodirenç bildirilmiştir. Bu çalışmada hastanemizde izole edilen CR-ABC suşlarında, kolistin heterojen direnç oranını ve kolistinin ve bu ilacın ikili kombinasyonlarının kolistin heterodirenç/direnç gelişimi üzerine etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Karbapenem dirençli A. baumannii izolatları vve standart ABC suşu [American Type Culture Collection (ATCC) 19606] üzerinde heterojen direnç analizi yapıldı. Gizli heterodirenç/direnci ortaya çıkarabil...

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Section: Discussionmentioning

confidence: 99%

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains

Gazel¹,

Otkun²

2018

mjima

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“…Colistin resistance among Acinetobacter strains, especially in A. baumannii, is increasing. In different parts of the world such as France (26), Argentina (27), Spain (28), Kuwait (29), and India (30), colistin-resistant Acinetobacter strains have been identified. There has been only one case of colistin-resistant Acinetobacter infection reported from Turkey (24).…”

Section: Discussionmentioning

confidence: 99%

Increasing resistance of nosocomial Acinetobacter baumannii: are we going to be defeated?

Güven¹,

Yılmaz²,

Güner³

et al. 2014

Turk J Med Sci

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In this work we have used the Viril theorem to investigate the dynamical stability of Hickson compact groups of galaxies. The average luminous mass of the galaxies member is approximately 1.3 ×0 11 M and average total luminous mass of group is approximately 4.6 ×0 11 M . The virial theorem has used to estimate the virial mass. The average Virial mass of group of galaxies is approximately 6.3 ×0 13 M This is attributed to the presence of large amount of dark matter which is more than 90% in this group. Hickson compact groups of galaxies are unstable system due to the virial to luminous masses ratio.

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“…Nephrotoxicity is a major concern when colistin is administered in patients with a history of chronic renal failure 17 . Colistin combination therapy is being strongly recommended against monotherapy due to selection of heteroresistant strains during prolonged colistin therapy 22 and heteroresistance strains were reported to be correlated with endemic infections in ICU 23 . Thus combination therapy might be beneficial for clinicians to prevent the emergence of resistance during therapy, decreased nephrotoxicity, especially if therapeutic options are limited.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Tunyapanit¹,

Pruekprasert²,

Laoprasopwattana³

et al. 2014

ScienceAsia

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ABSTRACT:The incidence of multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) is increasing worldwide and is leading to therapeutic problems. We investigated the in vitro activities of cefoperazone/sulbactam, colistin, imipenem, and rifampicin alone and in double combinations against 100 A. baumannii isolates from patients at Songklanagarind Hospital in Songkhla Province, Thailand. The E-test method was used to determine antimicrobial susceptibility, the minimal inhibitory concentration (MIC) and for antimicrobial combination testing. A. baumannii isolates were susceptible to colistin (97%), cefoperazone/sulbactam (69%), imipenem (45%), and rifampicin (13%). Fifty-nine percent of them were MDR A. baumannii. Colistin was superior to cefoperazone/sulbactam, rifampicin and imipenem against MDR A. baumannii and the MIC50, MIC90 of colistin were 0.75 and 1 µg/ml, respectively. Non-MDR A. baumannii isolates were susceptible to cefoperazone/sulbactam (100%), colistin (95%), imipenem (93%) and rifampicin (2%). Combinations of cefoperazone/sulbactam plus colistin or rifampicin, imipenem plus colistin or rifampicin and colistin plus rifampicin showed indifferent effects against most MDR isolates. Of all the antimicrobial combinations tested, cefoperazone/sulbactam plus rifampicin produced the highest percentages (42%) of synergy, partial synergy, and additive results. The activity rate of cefoperazone/sulbactam against MDR A. baumannii was higher when combined with rifampicin than colistin. Thus colistin had the greatest activity against most MDR and non-MDR A. baumannii isolates among all of the antibiotics tested. Cefoperazone/sulbactam and imipenem showed good activity against non-MDR isolates, and cefoperazone/sulbactam combined with rifampicin may be useful in treating infections caused by MDR isolates.

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Erratum to “Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistin” [Diagn Microbiol Infect Dis 65 (2009) 188–191]

Cited by 19 publications

References 0 publications

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains

Increasing resistance of nosocomial Acinetobacter baumannii: are we going to be defeated?

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

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