Erratum to “Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells” [Biochem. Biophys. Res. Commun. 376 (2008) 404–408]

Chung, Byung Hee; Kim, Jong Dai; Kim, Chun Ki; Kim, Junghwan; Won, Moo Ho; Lee, Han Soo; Dong, Mi Sook; Ha, Kwon Soo; Kwon, Young Geun; Kim, Young Myeong

doi:10.1016/j.bbrc.2009.04.065

Cited by 3 publications

(2 citation statements)

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“…The results showed that the phosphorylation of eNOS increased after icariin administration in a dose-and time-dependent manner. Examination of NO levels showed a significant increase compared to the control group [75]. Based on these studies, it is possible that icariin may also exert an effect on angiogenic signaling pathways in the corpus cavernosum endothelial cells.…”

Section: Epimediummentioning

confidence: 76%

“…Chung et al investigated the molecular effects and signaling pathways of icariin on angiogenesis using Human umbilical vein endothelial cells [HUVECs]. The results of this study indicate that the administration of icariin can increase the phosphorylation of ERK and Akt in a dose-dependent manner using Western blot analysis [75]. ERK and Akt's phosphorylation is a signaling mechanism that has a critical role in the angiogenesis process [76,77].…”

Section: Epimediummentioning

confidence: 87%

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Molecular Action of Herbal Medicine in Physiology of Erection and its Dysfunction

Rizal

Septiyorini

2022

BIO Web Conf.

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Erection is a physiological process that involves vascular, hormonal, and nervous factors. Erectile dysfunction is one of the male sexual problems that occur globally and is reported to affect men's quality of life. Herbal plants have been widely used for disease treatment, including the problem of erectile dysfunction. This paper aims to review the molecular potential of various plants in the physiology of erection and to treat erectile dysfunction. The literature search was carried out through the Pubmed and Google Scholar databases regarding the molecular mechanisms of herbal plants and their potential involvement in the physiology of erection and overcoming erectile dysfunction. This paper focuses on six herbal plants: Panax ginseng, Ginkgo biloba, Epimedium, Black pepper, Tribulus terrestris, and Eurycoma longifolia. The six herbal plants have involvement in the erection process and have molecular potential in the treatment of erectile problems

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Section: Epimediummentioning

confidence: 76%

Section: Epimediummentioning

confidence: 87%

Molecular Action of Herbal Medicine in Physiology of Erection and its Dysfunction

Rizal

Septiyorini

2022

BIO Web Conf.

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Effects of Icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice

Zhang

et al. 2018

BioMed Research International

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Objective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin on atherosclerosis in high-fat diet-induced ApoE−/− mice and investigate mRNA-miRNA regulation based on microarray and bioinformatics analysis. Methods. The areas of atherosclerotic lesions in en face aorta were evaluated. Microarray analysis was performed on atherosclerotic aortic tissues. The integrative analysis of mRNA and miRNA profiling was utilized to suggest specific functions of gene and supply an integrated and corresponding method to study the protective effect of icariin on atherosclerosis. Results. Icariin attenuated the development of atherosclerosis that the mean atherosclerotic lesion area was reduced by 5.8% (P < 0.05). Significant changes were observed in mRNA and miRNA expression patterns. Several miRNAs obtained from the miRNA-Gene-Network might play paramount part in antiatherosclerotic effect of icariin, such as mmu-miR-6931-5p, mmu-miR-3547-5p, mmu-miR-5107-5p, mmu-miR-6368, and mmu-miR-7118-5p. Specific miRNAs and GO terms associated with icariin in the pathogenesis of atherosclerosis were validated using GO analysis and miRNA-GO-Network. MiRNA-Pathway-Network indicated that icariin induced miRNAs mainly regulate the signaling pathways of PI3K/Akt signaling pathway, Ras signaling pathway, ErbB signaling pathway, and VEGF signaling pathway in aorta atherosclerotic lesion. Conclusions. Our data provides evidence that icariin is able to exhibit one antiatherosclerotic action by mediating multiple biological processes or cascades, suggesting the pleiotropic effects of icariin in atherosclerosis alleviation. The identified gene functional categories and pathways are potentially valuable targets for future development of RNA-guided gene regulation to fight disease.

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Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study

et al. 2012

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We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the findings of others on EF compounds, we showed that Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. These results suggested that the exogenous phytomolecule Icaritin possessed the potential for enhancing bone formation via its osteopromotive but not an osteoinductive mechanism. Though some flavonoids were shown to regulate the coupling process of angiogenesis and osteogenesis during bone repair, our results suggested that Icaritin did not have direct effect on enhancing angiogenesis in vitro.

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Erratum to “Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells” [Biochem. Biophys. Res. Commun. 376 (2008) 404–408]

Cited by 3 publications

References 0 publications

Molecular Action of Herbal Medicine in Physiology of Erection and its Dysfunction

Molecular Action of Herbal Medicine in Physiology of Erection and its Dysfunction

Effects of Icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice

Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study

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