Erratum to: evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation

De, Santanu; Kline, Douglas

doi:10.1186/1471-213x-14-20

Cited by 5 publications

(3 citation statements)

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“…All seven isoforms are expressed in oocytes as well as eggs of mice; however, while all of them seem to interact with M-phase inducer phosphatase 2 (CDC25B) in mouse oocytes and eggs, 14-3-3 eta and 14-3-3 epsilon are not necessary for oocyte maturation, fertilization, and early embryonic development [14][15][16][17][18][19][20][21][22][23][24]. The 14-3-3 eta isoform appears to interact with α-tubulin at the metaphase II spindles of mouse eggs [14,15,[25][26][27]. In the granulosa cells of mice, 14-3-3 tau binds to follicle stimulating hormone (FSH) receptors to impact cell signaling [28].…”

Section: Micementioning

confidence: 99%

Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages

Covington

2021

Adv. J. Grad. Res.

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The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation proteins) are a family of abundant, highly conserved, ubiquitous, acidic, and homologous proteins expressed in most eukaryotes ranging from plants to animals, including humans, important in regulating a multitude of cellular processes such as signal transduction, cell cycle, protein trafficking, metabolism, apoptosis, and development. Mammals have been noted contain seven isoforms of these proteins (beta, epsilon, eta, gamma, sigma, tau/theta, and zeta), encoded by separate genes. The 14-3-3 proteins are known to interact with over 200 binding partners in isoform-specific, tissue-specific, and developmental stage-specific ways. The present review article encapsulates previously published research articles that report 14-3-3-interactors, and investigates isoform-specific interactions within a wide array of mammalian species, cells, tissues, organs, and developmental stages. Of the hundreds of binding partners of 14-3-3 discovered till date, this paper focuses on analyzing selected, representative interactors with key functional roles. The study would help a better understanding of isoform-specific interactions of this critical protein family in mammals.

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Section: Micementioning

confidence: 99%

Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages

Covington

2021

Adv. J. Grad. Res.

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“…We further constructed a gene co-expression network with PKPs and their top 50 neighbor genes, suggesting that PKPs may exert their function by interacting with proteins. De S et al have reported that 14-3-3 (YWHA) proteins, which have seven isoforms of 14-3-3 and were identified in the ovary [45][46][47][48], are known to interact with and regulate several binding partners including CDC25B phosphatase and PKPs [49][50][51]. It is of great value to explore the underlying mechanism of the interaction between YWHA and PKPs in ovarian cancer.…”

Section: Casesmentioning

confidence: 99%

Identification of PKP 2/3 as potential biomarkers of ovarian cancer based on bioinformatics and experiments

Gao

Guo

et al. 2020

Cancer Cell Int

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Background Plakophilins (PKPs) are widely involved in gene transcription, translation, and signal transduction, playing a crucial role in tumorigenesis and progression. However, the function and potential mechanism of PKP1/2/3 in ovarian cancer (OC) remains unclear. It’s of great value to explore the expression and prognostic values of PKP1/2/3 and their potential mechanisms, immune infiltration in OC. Methods The expression levels, prognostic values and genetic variations of PKP1/2/3 in OC were explored by various bioinformatics tools and databases, and PKP2/3 were selected for further analyzing their regulation network and immune infiltration. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathways (KEGG) enrichment were also conducted. Finally, the expression and prognosis of PKP2 were validated by immunohistochemistry. Results The expression level and prognosis of PKP1 showed little significance in ovarian cancer, and the expression of PKP2/3 mRNA and protein were upregulated in OC, showing significant correlations with poor prognosis of OC. Functional enrichment analysis showed that PKP2/3 and their correlated genes were significantly enriched in adaptive immune response, cytokine receptor activity, organization of cell–cell junction and extracellular matrix; KEGG analysis showed that PKP2/3 and their significantly correlated genes were involved in signaling pathways including cytokine-mediated signaling pathway, receptor signaling pathway and pathways in cancer. Moreover, PKP2/3 were correlated with lymphocytes and immunomodulators. We confirmed that high expression of PKP2 was significantly associated with advanced stage, poor differentiation and poor prognosis of OC patients. Conclusion Members of plakophilins family showed various degrees of abnormal expressions and prognostic values in ovarian cancer. PKP2/3 played crucial roles in tumorigenesis, aggressiveness, malignant biological behavior and immune infiltration of OC, and can be regarded as potential biomarker for early diagnosis and prognosis evaluation in OC.

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“…The 14-3-3 (YWHA or tyrosine 3monooxygenase/tryptophan 5-monooxygenase activation protein) are a family of homologous, acidic proteins expressed abundantly and ubiquitously in most eukaryotes, and exist as different species-specific isoforms, with seven in mammals [39][40][41][42]. They govern critical cellular events such as cell cycle, cell division, signalling and development in various animal species [43][44][45][46][47]. These proteins are highly conserved and serve as stress-adaptive signalling agents [48].…”

Section: Strategies Of Plant Biotechnology To Meet the Increasing Demmentioning

confidence: 99%

Strategies of Plant Biotechnology to Meet the Increasing Demand of Food and Nutrition in India

2020

Int. Ann. Sci.

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A groundbreaking application of biotechnology research during the recent past has been improvement of crop health and production. India being one of the most rapidly developing countries with an enormous population and remarkable biodiversity, plant biotechnology promises significant potential to contribute to characterization and conservation of the biodiversity, increasing its usefulness. However, India’s green revolution was noted to be insufficient to feed the country's teeming millions. Therefore, novel approaches in crop biotechnology had to be aimed at ensuring better productivity and quality of cultivars. This paper provides a comprehensive review of research undertaken mainly in the last couple of decades along with potential strategies in plant biotechnology focusing on specific grain and seed crops of key agricultural as well as dietary importance to meet the growing demand of food and nutrition in India, while also proposing potential application of relevant global research findings in the Indian context. The analysis would help address the ever-increasing worldwide socio-economic necessity for greater food security, particularly during times of crisis such as the recent Coronavirus Infectious Disease 2019 (COVID-19) pandemic.

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Erratum to: evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation

Cited by 5 publications

References 1 publication

Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages

Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages

Identification of PKP 2/3 as potential biomarkers of ovarian cancer based on bioinformatics and experiments

Strategies of Plant Biotechnology to Meet the Increasing Demand of Food and Nutrition in India

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