2021
DOI: 10.21467/ajgr.10.1.16-22
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Binding Partners of 14-3-3 (YWHA) Protein Isoforms among Mammalian Species, Tissues, and Developmental Stages

Abstract: The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation proteins) are a family of abundant, highly conserved, ubiquitous, acidic, and homologous proteins expressed in most eukaryotes ranging from plants to animals, including humans, important in regulating a multitude of cellular processes such as signal transduction, cell cycle, protein trafficking, metabolism, apoptosis, and development. Mammals have been noted contain seven isoforms of these proteins (beta, epsilon, eta, gamma, si… Show more

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“…Metabolism represents the set of life-sustaining chemical reactions in cells and is essential for cancer progression. In general, gene expression is regulated by various factors, such as microRNAs and 14–3-3 proteins [ 24 26 ]. Therefore, enzyme activity cannot be determined from the gene expression level alone, and analysis of metabolites is required [ 15 , 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…Metabolism represents the set of life-sustaining chemical reactions in cells and is essential for cancer progression. In general, gene expression is regulated by various factors, such as microRNAs and 14–3-3 proteins [ 24 26 ]. Therefore, enzyme activity cannot be determined from the gene expression level alone, and analysis of metabolites is required [ 15 , 17 ].…”
Section: Discussionmentioning
confidence: 99%