Erratum to: Camel milk peptide improves wound healing in diabetic rats by orchestrating the redox status and immune response

Ebaid, Hossam; Abdel-Salam, Bahaa; Hassan, Iftekhar; Al-Tamimi, Jameel; Metwalli, Ali; Alhazza, Ibrahim M.

doi:10.1186/s12944-017-0421-x

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…Furthermore, camel milk is suggested to exert a number of therapeutic activities ( Hailu et al., 2016 , Mihic et al., 2016 ). Numerous studies suggest that camel milk has distinct therapeutic benefits, such as anti-diabetic ( Korish, 2014 , Korish et al., 2015 , Mirmiran et al., 2017 ), anti-toxic ( Al-Asmari et al., 2017 , Khan, 2017 ), anti-viral ( el Agamy et al., 1992 , El-Fakharany et al., 2017 , Lee et al., 2016 ), antibacterial ( Cardoso et al., 2013 , Rahimi and Kheirabadi, 2012 , Soliman et al., 2015 ), anti-rheumatoid arthritis ( Arab et al., 2017 ), anticancer ( Ayyash et al., 2017 , Chen et al., 2014 , Korashy et al., 2012 ), and wound healing ( Ebaid et al., 2015 , Ebaid et al., 2017 ) activities. In addition, camel milk has been used for centuries in the Middle East, Asian and North African cultures as a natural remedy for many common health problems ( Agrawal et al., 2011a , Agrawal et al., 2011b , Al-Ayadhi and Elamin, 2013 , Ehlayel et al., 2011a , Ehlayel et al., 2011b , Mohamad et al., 2009 , Mohamed et al., 2015 , Shori, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Potential antioxidant bioactive peptides from camel milk proteins

2018

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Camel milk is traditionally considered to have medicinal characteristics that it has potential health benefits and could help to treat several illnesses. Particularly, it is closest to human breast milk and has high levels of nutrients and bioactive components. The aim of this study was to explore the antioxidant peptides derived from protein fractions of camel milk. Camel milk proteins (CMP) were fractionated into camel casein protein (CCP) and camel whey protein (CWP), which were hydrolyzed with pepsin to produce peptic digests P-CCP and P-CWP, respectively. RP-HPLC was used for fractionation of the peptides from the P-CCP and P-CWP. The antioxidant activities were evaluated using superoxide anion generating system of xanthine oxidase (XOD) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay. Active peptides were analyzed using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) whereas a number of antioxidant peptides, with masses ranging from 913 to 2,951 Da, derived mainly from alpha-casein, lactophorin and lactoferrin, were identified. When yeast cells are used as a system for modeling mitochondrial disease, the peptides in caseins and whey fractions significantly enhanced the tolerance of yeast cells against peroxide-induced oxidative stress. The results show that both caseins and whey proteins of camel milk possess bioactive peptides with significant radical-scavenging activities and thus herald a fascinating opportunity for their potential as nutraceuticals or therapeutic peptides for prevention and treatment of oxidative stress-associated diseases.

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Section: Introductionmentioning

confidence: 99%

Potential antioxidant bioactive peptides from camel milk proteins

2018

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“…Furthermore, camel milk is suggested to exert several therapeutic activities (Hailu et al, 2016;Mihic et al, 2016). Numerous studies have also suggested that camel milk has distinct therapeutic benefits, such as antidiabetic (Korish, 2014;Korish et al, 2015;Mirmiran et al, 2017), anti-toxic (Al-Asmari et al, 2017Khan, 2017), anti-viral (el Agamy et al, 1992Lee et al, 2016;El-Fakharany et al, 2017), antibacterial (Rahimi and Kheirabadi, 2012;Cardoso et al, 2013;Soliman et al, 2015), anti-rheumatoid arthritis (Arab et al, 2017), anticancer (Korashy et al, 2012;Chen et al, 2014;Ayyash et al, 2018), and also wound healing (Ebaid et al, 2017) properties. However, the most dangerous or alarming situation is if people consume pasteurized camel milk that is contaminated with pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of methicillin-resistant (mecA gene) and heat-resistant Staphylococcus aureus strains in pasteurized camel milk

Yehia

Al-Masoud

Alarjani

et al. 2020

Journal of Dairy Science

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Staphylococcus aureus is a significant opportunistic pathogen in humans, dairy cattle, and camels. The presence of antibiotic-resistant and heat-resistant bacteria in camel milk has become a potential public health issue. The phenotypic and molecular characterization of methicillin-resistant staphylococcal strains recovered from pasteurized camel milk distributed in retail markets of Saudi Arabia was assessed. A total of 100 samples were collected between March and May 2017. Out of the 20 S. aureus isolates that were recovered from the pasteurized camel milk, 10 were found to be resistant to cefoxitin (30 µg) and, thus, were designated as methicillin-resistant strains. The resistance ratio of methicillin-resistant S. aureus isolates for a different class of antibiotics was determined by performing the antimicrobial susceptibility test and was estimated to be approximately 60%. Polymerase chain reaction assay was performed to amplify the methicillin-resistant gene mecA, and furthermore, nucleotide sequencing was performed to detect and verify the presence of methicillin-resistant strains. Upon sequencing the putative S. aureus methicillin-resistant strains, we obtained 96 to 100% similarity to the penicillin-binding protein 2a gene (mecA) of the S. aureus strain CS100. Moreover, the 10 methicillin-resistant S. aureus isolates were also identified to be heat resistant and were stable at temperatures up to 85°C for 60 s, with 3 isolates being heat resistant even at 90°C for 60 or 90 s. The mean decimal reduction time (D 85 value) was 111 s for all the 10 isolates. No difference was observed in the profile of total protein between the 10 methicillin-and heat-resistant S. aureus isolates and the S. aureus strain ATCC 29737, which was determined by sodium dodecyl sulfate-PAGE analyses. Therefore, we could conclude that a relatively high percentage of the tested pasteurized camel milk samples were contaminated with S. aureus (20%) and methicillin-and heat-resistant S. aureus (10%).

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Assessment of skin autofluorescence in children with diabetes mellitus type

Taranushenko Tatyana,

Salmin Vladimir,

Proskurina Margarita

et al. 2024

Glob J Obes Diabetes Metab Syndr

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Currently, camel milk has been considered around the world due to awareness of its unique health benefits. Camel milk is considered a superfood with special nutrients and therapeutic values. In diabetes or hyperglycemia, the cells may not respond properly to insulin or defects in insulin secretion by the pancreas, therefore glucose level of blood is excessive. Chronic hyperglycemia is associated with dysfunction in the eyes, heart, nerves, kidneys, liver, and blood vessels. Insulin and oral hypoglycemic drugs are used for diabetes, but a high percentage of patients cannot use allopathic drugs and rely on natural alternative healings. Furthermore, coagulation of oral insulin in an acidic environment neutralizes and decreases the efficacy of insulin. Camel milk contains insulin-like proteins and may be an effective alternative for insulin to treat type 1 and 2 and gestational diabetes. Camel milk may prepare about 60% of the insulin in diabetic patients and reduce blood sugar and required insulin doses of about 30% - 35% in type 1 diabetes patients. This milk is believed to be a suitable hypoglycemic agent in improving long-term glycemic control in experimental animals and diabetic patients, as well as improving diabetes risk factors such as liver and kidney failures and cardiovascular challenges. It appears that more scientific studies are needed to confirm the efficacy of processed camel milk on diabetes. This review represents scientific studies on how camel milk as a superfood can be effective in diabetes.

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Erratum to: Camel milk peptide improves wound healing in diabetic rats by orchestrating the redox status and immune response

Cited by 4 publications

References 1 publication

Potential antioxidant bioactive peptides from camel milk proteins

Potential antioxidant bioactive peptides from camel milk proteins

Prevalence of methicillin-resistant (mecA gene) and heat-resistant Staphylococcus aureus strains in pasteurized camel milk

Assessment of skin autofluorescence in children with diabetes mellitus type

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