Erratum

Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives

“…[1][2][3] In recent years, interest has also been focused on aza-analogs of 1,4-dihydropyridines such as dihydropyrimidines (DHPMs), which exhibit a pharmacological profile similar to classical dihydropyridine calcium channel modulators. [4][5][6][7][8][9][10] Apart from being well known for their calcium channel blocking activity, the dihydropyrimidines are also being explored for their possible therapeutic effects in treatment of AIDS. 11 This is due to the fact that their particular structure has been found in the natural marine alkaloids batzelladine A and B, which are the first lowmolecular-weight natural products reported in the literature to inhibit the binding of HIV gp-120 to CD4 cells, thus opening up a new area in the development of AIDS therapy.…”

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

“…In recent years interest has also focused on aza-analogs such as dihydropyrimidines of type 2 (DHPMs) which show a very similar pharmacological profile to classical dihydropyridine calcium channel modulators [3][4][5][6][7][8][9]. Over the past few years several lead-compounds were developed (i.e.…”

“…Over the past few years several lead-compounds were developed (i.e. SQ 32,926) [6][7][8] that are superior in potency and duration of antihypertensive activity to classical DHP drugs, and compare favorable with second-generation analogs such as amlodipine and nicardipine [6,7]. These inherently asymmetric DHPM derivatives are not only very potent calcium channel modulators, but also have been studied extensively to expand the existing structure-activity relationships and to get further insight into molecular interactions at the receptor level [3][4][5][6][7][8][9].…”

The Biginelli dihydropyrimidone synthesis using polyphosphate ester as a mild and efficient cyclocondensation/dehydration reagent

“…orally active antihypertensive agents 5, 6 [6][7][8] or α1a adrenoceptor-selective antagonists (7). 9 A very recent highlight in this context has been the identification of the structurally rather simple DHPM monastrol (8) as a mitotic kinesin Eg5 motor protein inhibitor and potential new lead for the development of anticancer drugs. 10 Apart from synthetic DHPM derivatives, several marine natural products with interesting biological activities containing the dihydropyrimidine-5-carboxylate core have recently been isolated.…”