Errata to: Advanced Time-Correlated Single Photon Counting Applications

Becker, Wolfgang

doi:10.1007/978-3-319-14929-5_20

Cited by 72 publications

(114 citation statements)

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“…Different from intensity-based imaging, molecular lifetime is a relatively stable parameter in certain ambient environments, and can elude effects of dye concentration, heterogeneous distribution, and light scattering in tissue. This relatively 'intrinsic' property of lifetime imaging makes it a strong candidate for imaging tissue oxygen condition, and is considered sufficiently sensitive to produce high-contrast spatial heterogeneous information of tissue oxygenation [39,40]. In addition, quenching method is a reversible way, in which the upper state lifetime or the luminescence intensity of the oxygen-sensitive dye is reduced with high oxygen concentration, but can be recovered with low oxygen concentration.…”

Section: Photoacoustic Imaging In Po 2 Measurementmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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Oxygen level, including blood oxygen saturation (sO 2 ) and tissue oxygen partial pressure (pO 2 ), are crucial physiological parameters in life science. This paper reviews the importance of these two parameters and the detection methods for them, focusing on the application of photoacoustic imaging in this scenario. sO 2 is traditionally detected with optical spectra-based methods, and has recently been proven uniquely efficient by using photoacoustic methods. pO 2 , on the other hand, is typically detected by PET, MRI, or pure optical approaches, yet with limited spatial resolution, imaging frame rate, or penetration depth. Great potential has also been demonstrated by employing photoacoustic imaging to overcome the existing limitations of the aforementioned techniques.

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Section: Photoacoustic Imaging In Po 2 Measurementmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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“…FRET between eGFP‐ and mCherry‐labeled proteins only occurs when they are less than 8 nm apart, a distance corresponding to intermolecular protein interactions . The FRET efficiency is ideally measured through the decrease of the fluorescence lifetime of eGFP by fluorescence lifetime imaging microscopy (FLIM) …”

Section: Resultsmentioning

confidence: 99%

A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1

Zaayter

Mori

Ahmad

et al. 2019

Chemistry A European J

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During DNA replication, ubiquitin‐like, containing PHD and RING fingers domains 1 (UHRF1) plays key roles in the inheritance of methylation patterns to daughter strands by recognizing through its SET and RING‐associated domain (SRA) the methylated CpGs and recruiting DNA methyltransferase 1 (DNMT1). Herein, our goal is to identify UHRF1 inhibitors targeting the 5′‐methylcytosine (5mC) binding pocket of the SRA domain to prevent the recognition and flipping of 5mC and determine the molecular and cellular consequences of this inhibition. For this, we used a multidisciplinary strategy combining virtual screening and molecular modeling with biophysical assays in solution and cells. We identified an anthraquinone compound able to bind to the 5mC binding pocket and inhibit the base‐flipping process in the low micromolar range. We also showed in cells that this hit impaired the UHRF1/DNMT1 interaction and decreased the overall methylation of DNA, highlighting the critical role of base flipping for DNMT1 recruitment and providing the first proof of concept of the druggability of the 5mC binding pocket. The selected anthraquinone appears thus as a key tool to investigate the role of UHRF1 in the inheritance of methylation patterns, as well as a starting point for hit‐to‐lead optimizations.

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“…99,161,162 Similar to previous components, also in this case, the main impairments are high cost, high power dissipation, and limited performance (e.g., conversion time, linearity, time resolution, and so on). After that, a final stage provides a digital number that encodes such time with respect to the synchronization signal.…”

Section: Timing Electronicsmentioning

confidence: 96%

New frontiers in time-domain diffuse optics, a review

et al. 2016

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The recent developments in time-domain diffuse optics that rely on physical concepts (e.g., time-gating and null distance) and advanced photonic components (e.g., vertical cavity source-emitting laser as light sources, single photon avalanche diode, and silicon photomultipliers as detectors, fast-gating circuits, and time-to-digital converters for acquisition) are focused. This study shows how these tools could lead on one hand to compact and wearable time-domain devices for point-of-care diagnostics down to the consumer level and on the other hand to powerful systems with exceptional depth penetration and sensitivity.

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Errata to: Advanced Time-Correlated Single Photon Counting Applications

Cited by 72 publications

References 0 publications

Photoacoustic Imaging in Oxygen Detection

Photoacoustic Imaging in Oxygen Detection

A Molecular Tool Targeting the Base‐Flipping Activity of Human UHRF1

New frontiers in time-domain diffuse optics, a review

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