Erk1/2 Activation in Stromal Fibroblasts From Sporadic Basal Cell Carcinomas

Aguayo, Rafael; Rafel, Marta; Santacana, Maria; Fusté, Noel P.; Garí, Eloi

doi:10.1097/dss.0000000000000367

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…SFN acts as a soluble cytoskeleton cofactor and binds to LAD1, and their overexpression is associated with increased MEK–ERK pathway activity. These data could explain why in our work, the expressions of LAD1 and SFN were low in BCC samples but high in SCC samples, as the ERK pathway has been reported activated in SCC ( 38 ), but not in BCC ( 39 ). Moreover, it is described that SCC has epithelial-mesenchymal transition (EMT), which confers aggressive capacities to the tumor.…”

Section: Discussionmentioning

confidence: 45%

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas

Matas‐Nadal¹,

Bech-Serra²,

Gatius³

et al. 2023

Molecular & Cellular Proteomics

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Section: Discussionmentioning

confidence: 45%

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas

Matas‐Nadal¹,

Bech-Serra²,

Gatius³

et al. 2023

Molecular & Cellular Proteomics

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“…In rare instances, alterations of the Wnt pathway and the involvement of β-catenin or the ERK (MAP kinase) pathway have been found. 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization

García-de-la-Fuente

Santacana

Valls

et al. 2018

The American Journal of Dermatopathology

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“…Its incidence is rising by almost 10 % each year [2]. Almost 70 % of sporadic BCCs hold alterations in the Hedgehog signaling pathway [3, 4]. Basal cell carcinoma was considered a tumor of elderly onset, occurring mainly in sun‐exposed areas in males [5].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for early‐onset basal cell carcinomas and the trend towards their female predominance

Matas‐Nadal

Sagristà²,

Gómez‐Arbonés

et al. 2021

J Deutsche Derma Gesell

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Summary Background A dramatic rise in the incidence rates of basal cell carcinoma (BCC) in young women has been reported. Objectives We investigate potential risk factors (RF) for sporadic BCC in young patients and the current distribution of such RF in the general population of Catalonia, comparing the differences among men and women. Patients and Methods A case‐control study was performed, 69 BCCs diagnosed in patients ≤ 45 years of age vs. 69 healthy controls. Afterward, 1,078 participants from the general population completed an RF questionnaire. Results Repeated sunburns were more frequent in instances of early‐onset BCC in covered skin than in sun‐exposed skin (P = 0.029). In the general population, 39.1 % of participants reported sunbed use (50.1 % in women, 10.9 % in men). Sunbed use was the only relevant RF more predominant in women than men, favoring the trend to female predominance of BCCs above other RF. Additionally, we found a significant trend in young participants for reduced sunbed use (P < 0.001), although they had the same percentage of repeated sunburns. Repeated sunburns are the most relevant RF for early‐onset BCCs that can be targeted in prevention campaigns. Conclusions We should be aware of the more relevant RF for early‐onset BCCs and their distribution among the general population to address preventive campaigns.

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Erk1/2 Activation in Stromal Fibroblasts From Sporadic Basal Cell Carcinomas

Abstract: The authors propose that there is a specific cell-type regulation of Erk activity in BCC, and this feature may be relevant during BCC formation. Stroma region from BCCs showed Erk activation and reduced proliferation. Conversely, Erk activation is barely detectable in proliferative BCCs.

Cited by 4 publications

References 22 publications

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas

Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas

Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization

Risk factors for early‐onset basal cell carcinomas and the trend towards their female predominance

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