Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization

García-de-la-Fuente, Ma Reyes; Santacana, Marı́a; Valls, Joan; Vilardell, Felip; Fernández‐Armenteros, Josep Manel; Garí, Eloi; Casanova, Josep Manel

doi:10.1097/dad.0000000000001042

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…As we mentioned earlier, although BCC is essentially located on sun-exposed skin, vulvar BCC is located on a nonexposed site. CK7 expression seemed to be associated with non–sun-exposed areas 8. Studies showed that positive CK7 and CK19 stain could suggest a glandular origin considering this genital region rich in sebaceous and apocrine units 9.…”

Section: Discussionmentioning

confidence: 95%

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Flipo

Bani

Rejaibi

et al. 2021

International Journal of Gynecological Pathology

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Basal cell carcinoma (BCC) is the most frequent skin cancer but <1% of the cases develop in the vulva. Histoprognostic features of vulvar BCCs are not recognized and, consequently, the treatment of the disease is not well codified. To overcome this lack of knowledge, we have performed a retrospective analysis of vulvar BBCs to assess the value of various histological features regarding the disease outcome. In all, 19 patients surgically treated for a vulvar BCC in the Centre Hospitalier Intercommunal de Créteil from March 1, 2000 to September 26, 2019 were retrieved. Clinical and histologic features were reviewed in all cases and analyzed in comparison with disease recurrence and patient's survival. The median age of the patients was 74 (range 54-99) yr. Tumor location on the labium majus was the most frequent (68%). None presented with a medical condition related to BCC. All the patients were treated by surgery alone, except one who benefited from additional radiotherapy. We found a significant association between tumor size and recurrences (P = 0.031). Other features associated with disease outcome were tumor thickness, treatment type, and surgical margins. Recurrence was observed for tumors larger than 20 mm with a surgical margin of less than 3 mm. A combination of tumor size, thickness, and surgical margin are histoprognostic factors more significant than tumor subtype.

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Section: Discussionmentioning

confidence: 95%

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Flipo

Bani

Rejaibi

et al. 2021

International Journal of Gynecological Pathology

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“…However, some authors have observed, 4 such as this study, CK7 expression showed differences depending on the BCC localization. In a study of García-de-la-Fuente et al (2018) 4 the percentages of CK7-positive cases located on the face, the trunk, and the non-sun exposed parts of the body (such as vulva, axilla, perineum) were 53. 3, 81.8, and 100%, respectively. Obviously, there was the lowest proportion of the CK7-positive BCCs located on the skin permanently exposed to sunlight.…”

Section: Discussionmentioning

confidence: 98%

Immunohistochemical expression of BerEP4, CK7 and EMA in basal cell carcinoma of the skin

Bartoš

2019

Bangabandhu Sheikh Mujib Medical University Journal

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The aim of this study was to evaluate the immunohistochemical expression status of BerEP4, EMA and CK7 in cutaneous basal cell carcinoma (BCC) and to find out whether there is some difference in the expression pattern related to the anatomic location of lesions. Biopsy specimens from 32 cases of BCC of the skin were enrolled. All samples were immunohistochemically stained for EpCAM (clone BerEP4), EMA (clone E29), and CK7 (clone OV-TL 12/30). All cases (32/32; 100%) were strongly positive for BerEP4, while the vast majority of tumors (28/32) were completely negative for EMA. Four BCCs (12.5%) exhibited a focal staining for EMA, but it was only sporadic and did not exceed 5% of tumor epithelium. Cytoplasmic expression of CK7 was found in 19 cases (19/32; 59.4%). Comparing both, the chronically sun-exposed and the intermittently sun-exposed anatomic locations, the percentages of CK7-positive BCCs were 47.8 and 88.9%, respectively. In conclusion, all lesions showed a strong expression of BerEP4, the use of this marker is helpful especially in individuals suspected of having multifocal BCC with many microlesions, morpheic BCC, or BCCs with mixed histomorphology.

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“…In this case, CK7 also showed low positive expression in the scalp lesions. 22 Studies have shown that AR is expressed in many skin tumors, with about 50–60% of BCC cases expressing AR. In contrast, AR is barely expressed in mature hair follicle, epidermal, or benign hair follicle tumors such as TE.…”

Section: Discussionmentioning

confidence: 99%

Eccrine Poroma with Concurrent Basal Cell Carcinoma: A Rare Combination

Shao,

Dong,

Liu

et al. 2023

CCID

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Eccrine poroma (EP) is a benign skin appendicular tumor that differentiates into the terminal sweat duct and is often differentiated from basal cell carcinoma (BCC) and seborrheic keratosis. This report describes a 58-year-old woman who presented with left occipital plaque. Histopathological analysis showed that the tumor cells were located in the lower part of the epidermis. The tumor cells were cuboidal or circular basal-like cells of the same size. The surrounding cells were not arranged in a palisade shape. Scattered tumor clusters composed of basal-like cells were also seen in the dermis, staining basophilic, and the surrounding cells were arranged in a palisade pattern. Immunohistochemistry showed that BerEP4, epithelial membrane antigen EMA, carcinoembryonic antigen CEA, Bcl-2, CD10, CK7 were positive, AR, PAS were negative. According to the pathological examination and immunohistochemical results, a case of eccrine poroma with concurrent basal cell carcinoma was diagnosed.

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Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 6 publications

References 36 publications

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features

Immunohistochemical expression of BerEP4, CK7 and EMA in basal cell carcinoma of the skin

Eccrine Poroma with Concurrent Basal Cell Carcinoma: A Rare Combination

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