Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of <i>O</i>-Methylated Catechin

Fujimura, Yoshinori; Fujino, Konatsu; Yoshimoto, Takanori; Nezu, Ayaka; Marugame, Yuki; Bae, Jae‐Hoon; Kumazoe, Motofumi; Tachibana, Hirofumi

doi:10.1021/acs.jnatprod.1c00337

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…Catechins, specifically EGCG, can cross-link with a specific allergen and immunoglobulin E to restrain the release of histamine from mast cells, which endows tea with anti-allergic functions. ,, The O-methylated derivatives of EGCG have a stronger anti-allergy effect than EGCG . Moreover, the intestinal absorption of methylated flavones is more effective than that of unmethylated flavones .…”

Section: Discussionmentioning

confidence: 99%

“…4−6 (−)-Epigallocatechin-3-O-gallate (EGCG), a predominant catechin in tea plants and tea infusions, has been reported to have antioxidant, antimicrobial, anticarcinogenic, and neuroprotective properties and thus has a therapeutic potential against various diseases. 7− 9 The O-methyl derivatives of EGCG, such as (−)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3″Me) and (−)-epigallocatechin-3-O-(4-O-methyl)gallate (EGCG4″Me), have garnered considerable attention because of their strong anti-allergic and antihypertensive effects. 10,11 Several O-methyl EGCGs, particularly EGCG3″Me, have been recognized as being enriched in specific tea cultivars, such as "Benifuuki", "Benihomare", "Tung ting oolong tea", "Jinmudan", and "Mingke 1."…”

Section: ■ Introductionmentioning

confidence: 99%

“…(−)-Epigallocatechin-3- O -gallate (EGCG), a predominant catechin in tea plants and tea infusions, has been reported to have antioxidant, antimicrobial, anticarcinogenic, and neuroprotective properties and thus has a therapeutic potential against various diseases. − The O -methyl derivatives of EGCG, such as (−)-epigallocatechin-3- O -(3- O -methyl)gallate (EGCG3″Me) and (−)-epigallocatechin-3- O -(4- O -methyl)gallate (EGCG4″Me), have garnered considerable attention because of their strong anti-allergic and antihypertensive effects. , Several O -methyl EGCGs, particularly EGCG3″Me, have been recognized as being enriched in specific tea cultivars, such as “Benifuuki”, “Benihomare”, “Tung ting oolong tea”, “Jinmudan”, and “Mingke 1.” , The O-methylated derivatives of EGCG exhibit a stronger anti-allergy effect than EGCG. For example, histamine-release assays show that the order of the anti-allergy effect is (−)-3′- O -methyl-epigallocatechin-3- O -(3,5- O -dimethyl)-gallate (EGCG3′,3″,5″triMe) = (−)-epigallocatechin-3- O -(3,5- O -dimethyl)-gallate (EGCG3″,5″diMe) > EGCG3″Me > EGCG in bone marrow-derived mouse mast cells .…”

Section: Introductionmentioning

confidence: 99%

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Novel Camellia sinensis O-Methyltransferase Regulated by CsMADSL1 Specifically Methylates EGCG in Cultivar “GZMe4”

Liu

Huang

et al. 2023

J. Agric. Food Chem.

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Epigallocatechin-3-O-(4-O-methyl)gallate (EGCG4″Me) in Camellia sinensis possesses numerous beneficial biological activities. However, the germplasm rich in EGCG4″Me and the O-methyltransferase responsible for EGCG4″Me biosynthesis are poorly understood. Herein, the content of EGCG3″Me and EGCG4″Me in the shoots of 13 cultivars was analyzed to demonstrate that EGCG4″Me is characteristically accumulated in the “GZMe4” cultivar but not in the other 12 cultivars. A novel O-methyltransferase (CsOMTL1) was identified from “GZMe4” using RNA-Seq and correlation analysis. Using the recombinant enzyme, EGCG4″Me was synthesized in vitro. Overexpression of CsOMTL1 via Agrobacterium-mediated genetic transformation caused constitutive accumulation of EGCG4″Me in C. sinensis callus. Moreover, the transcription factor CsMADSL1 localized in the nucleus activated the transcription of CsOMTL1 and specifically interacted with its promoter. Hence, our study identified a novel O-methyltransferase that characteristically catalyzes the synthesis of EGCG4″Me and a positive regulator of EGCG4″Me synthesis in “GZMe4”, which might provide a strategy for the breeding of a tea cultivar rich in EGCG4″Me.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Camellia sinensis O-Methyltransferase Regulated by CsMADSL1 Specifically Methylates EGCG in Cultivar “GZMe4”

Liu

Huang

et al. 2023

J. Agric. Food Chem.

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“…Consequently, the bioavailability of O ‐methylated catechins is higher than that of EGCG (Dai, Ruan, et al., 2020). The anti‐allergic (Fujimura et al., 2021) and anti‐hypertensive (Kurita et al., 2010) effects of EGCG3″Me were higher than those of EGCG. Additionally, EGCG3″Me was reported to have potential applications in skincare products (Kim, Han, et al., 2019), as well as a promising candidate for enhancing the performance of split vaccines (Kumazoe et al., 2021).…”

Section: Special Tea Products Featuring Tea Polyphenolsmentioning

confidence: 97%

Special tea products featuring functional components: Health benefits and processing strategies

Yang

Meng

Shi

et al. 2023

Comp Rev Food Sci Food Safe

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The functional components in tea confer various potential health benefits to humans. To date, several special tea products featuring functional components (STPFCs) have been successfully developed, such as O‐methylated catechin‐rich tea, γ‐aminobutyric acid‐rich tea, low‐caffeine tea, and selenium‐rich tea products. STPFCs have some unique and enhanced health benefits when compared with conventional tea products, which can meet the specific needs and preferences of different groups and have huge market potential. The processing strategies to improve the health benefits of tea products by regulating the functional component content have been an active area of research in food science. The fresh leaves of some specific tea varieties rich in functional components are used as raw materials, and special processing technologies are employed to prepare STPFCs. Huge progress has been achieved in the research and development of these STPFCs. However, the current status of these STPFCs has not yet been systematically reviewed. Here, studies on STPFCs have been comprehensively reviewed with a focus on their potential health benefits and processing strategies. Additionally, other chemical components with the potential to be developed into special teas and the application of tea functional components in the food industry have been discussed. Finally, suggestions on the promises and challenges for the future study of these STPFCs have been provided. This paper might shed light on the current status of the research and development of these STPFCs. Future studies on STPFCs should focus on screening specific tea varieties, identifying new functional components, evaluating health‐promoting effects, improving flavor quality, and elucidating the interactions between functional components.

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“…Over the last 20 years, the world's tea processing has doubled with the growth of the world's population, and an increase in tea plantation demand has also taken place (from two to four million hectares) [28]. Tea quality depends on the contents of bioactive compounds such as polyphenols, caffeine, and theanine, amino acids, volatile compounds, and alkaloids [4,[29][30][31][32][33][34][35], which underly the delicious taste, pleasant flavor, and beneficial health effects of tea [36][37][38][39][40][41][42][43]. Transcriptome research has provided new insights into the metabolic pathways and key genes involved in the biosynthesis, transport, and metabolism of catechins, theanine, and caffeine in tea plant tissues, as well as their relationship with genes that regulate abiotic stress responses [44][45][46][47][48][49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Functional Single-Nucleotide Polymorphisms (SNPs) and Leaf Quality in Tea Collection under Nitrogen-Deficient Conditions

Samarina,

Fedorina,

Kuzmina

et al. 2023

IJMS

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This study discusses the genetic mutations that have a significant association with economically important traits that would benefit tea breeders. The purpose of this study was to analyze the leaf quality and SNPs in quality-related genes in the tea plant collection of 20 mutant genotypes growing without nitrogen fertilizers. Leaf N-content, catechins, L-theanine, and caffeine contents were analyzed in dry leaves via HPLC. Additionally, the photochemical yield, electron transport efficiency, and non-photochemical quenching were analyzed using PAM-fluorimetry. The next generation pooled amplicon–sequencing approach was used for SNPs-calling in 30 key genes related to N metabolism and leaf quality. The leaf N content varied significantly among genotypes (p ≤ 0.05) from 2.3 to 3.7% of dry mass. The caffeine content varied from 0.7 to 11.7 mg g−1, and the L-theanine content varied from 0.2 to 5.8 mg g−1 dry leaf mass. Significant positive correlations were detected between the nitrogen content and biochemical parameters such as theanine, caffeine, and most of the catechins. However, significant negative correlations were observed between the photosynthetic parameters (Y, ETR, Fv/Fm) and several biochemical compounds, including rutin, Quercetin-3-O-glucoside, Kaempferol-3-O-rutinoside, Kaempferol-3-O-glucoside, Theaflavin-3′-gallate, gallic acid. From our SNP-analysis, three SNPs in WRKY57 were detected in all genotypes with a low N content. Moreover, 29 SNPs with a high or moderate effect were specific for #316 (high N-content, high quality) or #507 (low N-content, low quality). The use of a linear regression model revealed 16 significant associations; theaflavin, L-theanine, and ECG were associated with several SNPs of the following genes: ANSa, DFRa, GDH2, 4CL, AlaAT1, MYB4, LHT1, F3′5′Hb, UFGTa. Among them, seven SNPs of moderate effect led to changes in the amino acid contents in the final proteins of the following genes: ANSa, GDH2, 4Cl, F3′5′Hb, UFGTa. These results will be useful for further evaluations of the important SNPs and will help to provide a better understanding of the mechanisms of nitrogen uptake efficiency in tree crops.

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Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin

Cited by 8 publications

References 49 publications

Novel Camellia sinensis O-Methyltransferase Regulated by CsMADSL1 Specifically Methylates EGCG in Cultivar “GZMe4”

Novel Camellia sinensis O-Methyltransferase Regulated by CsMADSL1 Specifically Methylates EGCG in Cultivar “GZMe4”

Special tea products featuring functional components: Health benefits and processing strategies

Analysis of Functional Single-Nucleotide Polymorphisms (SNPs) and Leaf Quality in Tea Collection under Nitrogen-Deficient Conditions

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