Erinacine E as a Kappa Opioid Receptor Agonist and Its New Analogs from a Basidiomycete, Hericium ramosum.

Saito, Toshiyuki; Aoki, Fukumatsu; Hirai, Hideo; Inagaki, Taisuke; Matsunaga, Yasue; Sakakibara, Tatsuo; Sakemi, Shinichi; Suzuki, Yumiko; Watanabe, Shuzo; Suga, Osamu; Sujaku, Tetsujo; Smogowicz, Adam A.; Truesdell, Susan; Wong, John W.; Nagahisa, Atsushi; Kojima, Yasuhiro; Kojima, Nakao

doi:10.7164/antibiotics.51.983

Cited by 66 publications

(44 citation statements)

References 22 publications

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“…Erinacin E (9) from Hericium coralloides fermentation broth is a highly selective agonist at the kappa opiod receptor (IC50 of 0.8 mM, binding at the m opiod receptor with an I 50 of >200 mM). Such compounds may exhibit antinociceptive activity without side effects observed with m receptor agonists like morphine (Saito et al, 1998). Screening investigations of selected basidiomycetes indicate inhibitory effects of P. betulinus, G. applanatum, H. annosum, Fomitopsis pinicola and Daedaleopsis confragosa on neutral endopeptidase (enkephalinase) (IC50 values between 40 and 55 mg/mL).…”

Section: Mushrooms As Centrally Acting Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

121

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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Section: Mushrooms As Centrally Acting Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

121

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show abstract

“…Erinacines Q and P may be the common biosynthetic intermediates of cyathane xylosides in this basidiomycete, and others such as erinacines A, B, C and H in H. erinaceum, [1][2][3][4]8) erinacines E, F and G in H. romosum, 6,10,11) and striatals and striatins in Cyathus spp. 5,[9][10][11] and Gerronemaˆbula.…”

Section: )mentioning

confidence: 99%

“…Erinacines have potent stimulating activity for nerve-growth-factor synthesis [1][2][3][4] and agonistic activity towards the k opioid receptor. 6) In particular, erinacine C (5) is known to the most potent stimulator of the erinacines for nerve-growthfactor synthesis. 1) In addition, striatins have leishmanicidal activity.…”

mentioning

confidence: 99%

Erinacine Q, a New Erinacine fromHericium erinaceum, and its Biosynthetic Route to Erinacine C in the Basidiomycete

Kenmoku

Shimai

Toyomasu

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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“…Specifically, rats treated with showed an increase in the levels of both noradrenaline and homovanillic acid, and displayed enhanced NGF secretions in both the locus coeruleus and hippocampus. Erinacine E is a selective agonist of κ-opioid receptors (Saito et al, 1998) which is present on the peripheral terminals of primary afferent neurons. It has been reported that activation of these receptors reduces hyperalgesia in a rat model of inflammation (Stein et al, 1989).…”

Section: In Vivo Modelmentioning

confidence: 99%