A comprehensive review of the therapeutic effects of Hericium erinaceus in neurodegenerative disease

Kim, Young Ock; Lee, Sang Won; Kim, Jin-Seong

doi:10.14480/jm.2014.12.2.77

Cited by 4 publications

(2 citation statements)

References 21 publications

(20 reference statements)

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“…NGF is essential for protecting nerve tissue and maintaining neuron functionality where studies have shown NGF levels in MDD patients is also significantly reduced [ 120 ]. Interestingly, NGF itself is unable to pass the BBB highlighting the benefits of these compounds which stimulate NGF production within the brain and encourage nerve myelination throughout the CNS [ 121 ]. Perhaps such myelination effects may also aid in alleviating the symptoms of FM in patients where improper myelination of nerves is a possible issue [ 56 ].…”

Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%

“…Such anti-inflammatory activity may also prove beneficial in alleviating symptoms of autoimmune co-morbidities of mental illness. Studies show when consuming H. erinaceus adults with mild cognitive impairment and menopausal women were less depressed, anxious with improved cognitive abilities compared to placebo control groups [ 121 ]. Studies are warranted however, confirming the efficacy of biological extracts from H. erinaceus mushrooms comparative to consuming the entire fruiting body of the mushroom at a therapeutic level.…”

Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%

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Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain

Meade

Hehir

Rowan³

et al. 2022

JoF

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Mushrooms have been used as traditional medicine for millennia, fungi are the main natural source of psychedelic compounds. There is now increasing interest in using fungal active compounds such as psychedelics for alleviating symptoms of mental health disorders including major depressive disorder, anxiety, and addiction. The anxiolytic, antidepressant and anti-addictive effect of these compounds has raised awareness stimulating neuropharmacological investigations. Micro-dosing or acute dosing with psychedelics including Lysergic acid diethylamide (LSD )and psilocybin may offer patients treatment options which are unmet by current therapeutic options. Studies suggest that either dosing regimen produces a rapid and long-lasting effect on the patient post administration with a good safety profile. Psychedelics can also modulate immune systems including pro-inflammatory cytokines suggesting a potential in the treatment of auto-immune and other chronic pain conditions. This literature review aims to explore recent evidence relating to the application of fungal bioactives in treating chronic mental health and chronic pain morbidities.

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Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%

Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%