ERG positive prostatic cancer may show a more angiogenetic phenotype

Strzępek, Aleksandra; Kaczmarczyk, Karolina; Białas, Magdalena; Szpor, Joanna; Dyduch, Grzegorz; Szopiński, Tomasz; Chłosta, Piotr; Okoń, Krzysztof

doi:10.1016/j.prp.2014.07.009

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…In one of our previous studies, the frequency of ERG positivity in PC was 46%, which is similar to other European populations [5]. We found that ERG-positive PC have a higher number of microvessels [6]. Tumor vascularity is dependent on a number of factors; in some cases mast cells were shown to influence microvessel density [7,8], while in others no such association was seen [9].…”

Section: Introductionsupporting

confidence: 86%

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Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Miłek¹,

Kaczmarczyk-Sekuła²,

Strzępek³

et al. 2016

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A significant proportion of prostatic adenocarcinomas show recurrent translocation leading to ERG expression. Previously we found that ERG+ cases have higher microvessel density than negative ones. One factor influencing angiogenesis in cancer is mast cells. The aim of the present study was to evaluate the relationship between microvessels, mast cells and ERG status. In summary, we demonstrated an interrelationship between mast cells, microvascular density and ERG status in prostatic carcinoma.

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Section: Introductionsupporting

confidence: 86%

“…The results were expressed as the number of positive cells per square millimeter. The data on microvessel density were derived from our previous work [6]. The person performing the counting was not aware of the ERG status or other data under study.…”

Section: Methodsmentioning

confidence: 99%

Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Miłek¹,

Kaczmarczyk-Sekuła²,

Strzępek³

et al. 2016

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“…Prostatic carcinomas bearing the translocation involving ETS genes may differ in a number of features. For example, in one of the previous studies we demonstrated that they are characterized by higher microvessel density [2]. Regulatory T lymphocytes (Tregs), well identified by FOXP3 expression, are the negative regulators of the immune response.…”

Section: Introductionmentioning

confidence: 90%

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Kaczmarczyk-Sekuła¹,

Gałązka²,

Glajcar³

et al. 2016

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Prostatic carcinoma is the most frequent cancer in males in the Western world. A significant proportion of these cancers have a recurrent translocation involving ETS family genes, which leads to the overexpression of ERG transcription factor. Prostate cancers, which bear this mutation, differ in a number of features, including tumor microenvironment. One of the components of the tumor microenvironment is FOXP3 positive lymphocytes, which may participate in breaking immunosurveillance and promoting tumor growth. 2 for all cases, 21.43/ mm 2 for the ERG negative and 42.28/mm 2 for the ERG positive group (p < 0.02). There were no significant relationships between FOXP3 positive cell count and any other parameters studied. Our results suggest that the immune response may differ between ERG negative and ERG positive prostatic carcinomas.

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“…Although a number of studies were published on the subject, it is still unclear whether translocation-associated prostate cancers are different in morphology or behavior [15]. In our opinion, some differences exist in terms of both morphology and stage as well as interaction with the tumor microenvironment [3,16,17,18]. KDM1A, CHD1, and androgen receptor were identified as forming a complex responsible for targeted DNA breaks, which lead to TMPRSS2-ETS translocation [19].…”

Section: Discussionmentioning

confidence: 99%

Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas

Okoń¹,

Dyduch²,

Białas³

et al. 2020

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Prostatic carcinoma (PC) is the most frequent urologic cancer and one of the most frequent cancers in males; it is a heterogeneous disease, in terms of molecular features, morphology and prognosis. About half of cases depends on TMPRSS2-ETS translocation which leads to a production of ERG transcription factor. ERG+ and ERG-cancers seem to differ in a number of features, which could lead to an altered nuclear structure; the aim of the study was to test this hypothesis. The material consisted of total 39 PC cases, representing ERG+ and ERG-, as well as Gleason pattern 3 and 4. Filtering by color deconvolution and automatic segmentation were used, and the properly detected nuclei were manually selected. From each case fifty nuclei were obtained; then geometric features and texture parameters were assessed. The analysis of the collected data showed differences both between ERG+/ERG-and Gleason pattern 3 and 4 cases in most of the features analyzed. Our results suggest that indeed the ERG status, thus likely TMPRSS2-ETS translocation, has an impact on morphology of nuclei in PC, and their differences are evident enough to be detectable by image analysis.

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ERG positive prostatic cancer may show a more angiogenetic phenotype

Cited by 7 publications

References 28 publications

Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Prostate cancer with different ERG status may show different FOXP3-positive cell numbers

Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas

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