Erfolge der Insulindepot-Behandlung des Diabetes Durch Insulin-Durante

Experiences with Zinc Insulin (and Zinc‐protamineinsulin)

“…(2) UMBER and S T~R R I N G in Berlin have laboured with insulin pastes under the name of insulin durante, and these pastes are stated to have an even, protracted insulin effect. (3) SCOTT and FISCIIER a t one of the most eminent laboratories of the world with regard to the insulin research, the Connought 1,aboratories a t the University of Toronto, in the autumn of 1935 published their examinations on animals, through which they proved that the effect of insulin is delayed and prolonged, if certain metallic salts, among others zinc salts in a certain concentration, are added to insulin solutions. (4) The altered effect of insulin was considered probably to be caused by changes of the chemical structure of the insulin showing itself among other things in a decreased solutibility in water.…”