Erfahrungen mit der Therapie der Spondylitis ankylosans in der DDR unter Berücksichtigung der Radium-224-Therapie

Seyfarth, H

doi:10.1055/s-2008-1047965

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2001

2007

Publication Types

Select...

Book3

Article1

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

2001

Interdisziplinäre Klinische Rheumatologie

View full text Add to dashboard Cite

Renaissance of 224Ra for the treatment of ankylosing spondylitis: clinical experiences

Tiepolt

Grüning

Franke

2002

Nuclear Medicine Communications

View full text Add to dashboard Cite

Radium (224Ra) is commercially available again for the treatment of ankylosing spondylitis. Twenty patients suffering from ankylosing spondylitis were treated with weekly intravenous (i.v.) injections of 1 MBq 224Ra for 10 weeks. Therapeutic effect was measured by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and full blood count, as well as a completion of the Bath ankylosing spondylitis functional index (BASFI) questionnaire. Follow-up was done after three and six months. At the end of the treatment course pain and movement restrictions had improved subjectively in 12 out of 20 patients. These patients were also able to discontinue or reduce their analgesic or anti-inflammatory medications. Subjective improvement was well correlated with a reduction of CRP by 45% and BASFI by 73%. At the six-month follow-up, ten patients reported a lasting improvement, whereas two had suffered a relapse. A late therapeutic response after three months was seen in a single patient only. Patients who did not respond to radium had lower initial levels of acute-phase reactants and peripheral joint involvement. Only mild side-effects, e.g. temporary worsening of pain, were observed. Leukocytes and platelets reversibly decreased by 25%, respectively. It is concluded that 224Ra is an effective and safe treatment for ankylosing spondylitis.

show abstract

Erfahrungen mit der Therapie der Spondylitis ankylosans in der DDR unter Berücksichtigung der Radium-224-Therapie

Cited by 4 publications

References 0 publications

Radium-224

Radium-224

Radiosynoviorthese, [224Ra] Radiumtherapie und Röntgenstrahlentherapie

Renaissance of 224Ra for the treatment of ankylosing spondylitis: clinical experiences

Contact Info

Product

Resources

About