Erectile Dysfunction Is the Main Correlate of Depression in Men with Chronic Spinal Cord Injury

Barbonetti, Arcangelo; D’Andrea, Settimio; Castellini, Chiara; Totaro, Maria; Medvedec, Mario; Cavallo, Francesca; Felzani, Giorgio; Necozione, Stefano; Francavilla, Sandro

doi:10.3390/jcm10102090

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…Recent studies found that the prevalence of major depression among community-dwelling adults with traumatic SCI is three times higher than in the general population (21). Observational data analysis from 3,172 individuals with SCI revealed psychosocial factors as significant predictors of post-injury depression, with a strong correlation between levels of despair and the quality of social support (22,23). The relationship between pain and depression is established, with effective treatment shown to reduce depressive symptoms (24).…”

Section: Introductionmentioning

confidence: 99%

Determining the Level of Occupational Performance and its Association with Depression among Patients with Spinal Cord Injury

Saeed,

Khan,

Safoora

et al. 2024

JHRR

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Background: Spinal Cord Injury (SCI) presents a significant challenge to healthcare systems worldwide, often leading to severe physical disability and psychological distress, including depression. The rehabilitation process for SCI patients is complex, necessitating a multidimensional approach that addresses both the physical and psychological aspects of recovery. The interplay between occupational performance and mental health among individuals with SCI remains a critical area of investigation, particularly in regions like Peshawar, Pakistan, where such studies are scarce. Objective: The primary objective of this study was to explore the association between occupational performance and depression among individuals with SCI in Peshawar, with a secondary aim of comparing occupational performance levels and their relationship with depression in this demographic. Methods: A cross-sectional study was conducted at the Paraplegic Centre Peshawar over a six-month period, utilizing convenience sampling to recruit 120 participants. Depression and occupational performance were assessed using the Beck Depression Inventory and the Barthel Index Scale, respectively. Data analysis was performed using SPSS version 22, with statistical significance set at p<0.05. Results: The study found that 35.8% of participants experienced moderate depression, while mild mood disturbances and borderline clinical depression were reported by 21.7% and 12%, respectively. Severe and extreme depression were less common, observed in 9.8% and 1.1% of the sample. Regarding occupational performance, 37% were totally dependent, 50% were severely dependent, and 13% were moderately independent. Statistical analysis revealed a significant association between occupational performance and depression levels (Pearson Chi-Square = 17.986, p=.05; Likelihood Ratio = 18.683, p=.04; Fisher Exact Test = 9.214, p=.002). Conclusion: The study highlights a notable correlation between occupational performance and depression among SCI patients, emphasizing the need for integrated rehabilitation programs that address both physical disabilities and mental health concerns. Enhancing occupational performance through targeted interventions may reduce depression levels, thereby improving overall quality of life for SCI patients.

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Section: Introductionmentioning

confidence: 99%

Determining the Level of Occupational Performance and its Association with Depression among Patients with Spinal Cord Injury

Saeed,

Khan,

Safoora

et al. 2024

JHRR

View full text Add to dashboard Cite

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“…Sexual health can be negatively impacted by a spinal cord injury and research has shown that improving sexual functioning can improve the quality of life of people living with SCI [ 76 – 79 ]. There are many ways sexual dysfunction and fertility issues can be successfully managed so we recommend that at a minimum, annual assessments should occur.…”

Section: Introductionmentioning

confidence: 99%

Primary Care in the Spinal Cord Injury Population: Things to Consider in the Ongoing Discussion

Gibson-Gill

Mingo

2023

Curr Phys Med Rehabil Rep

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Purpose of Review Spinal cord injury (SCI) creates unique needs that if not recognized and addressed timely can have detrimental effects on the health and quality of life (QOL) of people living with a SCI. Primary preventive health care is shown to decrease morbidity and mortality, yet the SCI population reportedly faces challenges getting access to this care. This area in SCI health care is still largely understudied with no consensus on the ideal way or which health care provider is best to provide primary care for this population. Findings Preventive care is generally provided by general primary care providers, but not all primary care providers are trained in recognizing and addressing spinal cord injury-specific needs. SCI providers generally are not trained in addressing all aspects of preventive care. Knowing the recommended preventive care screenings, recognizing and managing specific conditions seen after a SCI, and seamless coordination of care between general practitioners and SCI specialists are some of the interventions to help prevent health complications, decrease morbidity and mortality, improve health outcomes, and promote QOL in this patient population. Summary Prioritized focus on preventive care is necessary for a positive impact on the overall health and QOL in this population. Addressing the knowledge gap reported by primary care providers and SCI providers may help increase the probability of SCI patients getting their preventive and specialty care needs addressed. We present a “cheat sheet” of recommendations for the preventive care evaluation of a person living with a SCI.

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“…Additionally, ED often decreases the quality of life of the partner of patients with ED. In recent years, ED has been reported to be a major cause of depression in patients with chronic spinal cord injury [ 5 ]. Therefore, the development of treatment strategies for ED is important, and understanding the underlying mechanism is essential.…”

Section: Introductionmentioning

confidence: 99%

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

et al. 2021

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Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.

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Erectile Dysfunction Is the Main Correlate of Depression in Men with Chronic Spinal Cord Injury

Cited by 7 publications

References 54 publications

Determining the Level of Occupational Performance and its Association with Depression among Patients with Spinal Cord Injury

Determining the Level of Occupational Performance and its Association with Depression among Patients with Spinal Cord Injury

Primary Care in the Spinal Cord Injury Population: Things to Consider in the Ongoing Discussion

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

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