Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici.

Fedele, Domenico; Coscelli, C; Santeusanio, Fausto; Bortolotti, Angela; Chatenoud, Liliane; Colli, Enrico; Landoni, M; Parazzini, Fabio

doi:10.2337/diacare.21.11.1973

Cited by 208 publications

(172 citation statements)

References 4 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…The Massachusetts Male Aging Study (44) found that the crude incidence of ED in the men with diabetes was 50.7 per 1,000 population-years versus 24.8 in those without diabetes. This figure was similar to results in a convenience sample of 1,010 men with diabetes (68 per 1,000 population-years) (2).…”

Section: Male Sexual Dysfunctionsupporting

confidence: 76%

“…In men with diabetes, the relative risk for ED increases with poor glycemic control, duration of diabetes, and the number of other nonurologic complications of diabetes (i.e., retinopathy, nephropathy, and limb loss) (40,(45)(46)(47). Studies that focus on the impact of race/ethnicity, modifiable risk factors (e.g., weight loss), and comorbidities on ED are still needed.…”

Section: Male Sexual Dysfunctionmentioning

confidence: 99%

“…Erectile dysfunction (ED) occurs in a substantial number of men with diabetes, with prevalence estimates ranging from 20 to 71% (2,40,41). ED in diabetic men significantly impacts their quality of life (41,42).…”

Section: Male Sexual Dysfunctionmentioning

confidence: 99%

“…very common health problems that markedly increase in prevalence and incidence with advancing age (1)(2)(3). Diabetes is associated with an earlier onset and increased severity of urologic diseases, resulting in costly and debilitating urologic complications.…”

Section: Iabetes and Urologic Diseases Arementioning

confidence: 99%

See 3 more Smart Citations

Urologic Complications of Diabetes

et al. 2005

View full text Add to dashboard Cite

Section: Male Sexual Dysfunctionsupporting

confidence: 76%

Section: Male Sexual Dysfunctionmentioning

confidence: 99%

Section: Male Sexual Dysfunctionmentioning

confidence: 99%

Section: Iabetes and Urologic Diseases Arementioning

confidence: 99%

See 2 more Smart Citations

Urologic Complications of Diabetes

et al. 2005

View full text Add to dashboard Cite

“…In the largest study of prevalence and risk association [21,22], an Italian multicentre cross-sectional study of 9868 diabetic men 20 to 69 years old, ED was reported by 3534 (35.8 %) of patients. After accounting for the effect of age, Type II diabetic men (37/100) tend to report ED less frequently than Type I men (51/100); in both, a positive correlation was observed between ED and poor glycaemic control and smoking; BMI increased only the risk of ED in Type I diabetic men.…”

Section: Discussionmentioning

confidence: 99%

Erectile and endothelial dysfunction in Type II diabetes: a possible link

et al. 2001

View full text Add to dashboard Cite

Erectile dysfunction (ED) is a common complication and an important cause of decreased quality of life in men with diabetes. These patients present a risk of ED three-fold higher than the general population; the prevalence of ED increases with age, but in diabetic men it can occur 10 to 15 years earlier regardless of their insulin dependency status [1].The causes of ED in diabetic patients can be multifactorial, involving mainly vascular, neurological and Diabetologia (2001) AbstractAims/hypothesis. The aim of this study was to evaluate the relation between erectile dysfunction and endothelial functions, coagulation activation, peripheral and autonomic neuropathy in men with Type II (non-insulin-dependent) diabetes mellitus. Methods. We studied 30 Type II diabetic patients with symptomatic erectile dysfunction and 30 potent diabetic patients matched for age and disease. Endothelial functions were assessed with the l-arginine test, plasma thrombomodulin and cell adhesion molecules circulating concentrations. Haemostasis was evaluated with markers of thrombin activation and fibrinolysis. Quantitative sensory testing (vibratory, warming, and heat-pain thresholds), cardiovascular reflex tests and 24-h blood pressure monitoring were used to assess peripheral or autonomic neuropathy. Results. Mean erectile score and HbA 1 c were 10.5 5.8 and 8.3 1.6 % in patients with erectile dysfunction, and 24.0 0.7 and 6.8 1.4 % in those without erectile dysfunction, respectively (p < 0.001); there was a significant relation between HbA 1 c and erectile function score in patients with erectile dysfunction (r = ±0.45, p = 0.02). The decrease in blood pressure and platelet aggregation in response to l-arginine was lower (p < 0.05±0.02) in patients with erectile dysfunction, whereas soluble thrombomodulin, P-selectin and intercellular cell ahhesion molecule-1 concentrations were higher (p < 0.05±0.02). Indices of coagulation activation (F1 + 2 and d-dimers) and reduced fibrinolysis (PAI-1) were also found to be higher in erectile dysfunction patients. Heat-pain and warm perception thresholds, as well as cardiovascular reflex tests, were most commonly abnormal in patients with erectile dysfunction (p < 0.05). In multivariate analysis, HbA 1 c , MBP response to l-arginine, P-selectin, indices of coagulation, and quantitative sensory testing were independent predictors of erectile function score. Conclusion/interpretation. Erectile dysfunction in diabetic men correlates with endothelial dysfunction. A reduced nitric oxide activity might provide a unifying explanation. [Diabetologia (2001

show abstract