Hormones, Metabolism, Aging and Men's Health

Buvat, J.; Shabsigh, Ridwan; Guay, André; Gooren, Louis; Torres, Luiz Otávio; Meuleman, E.J.H.; Graziottin, Alessandra

doi:10.1002/9780470755235.ch18

Cited by 22 publications

(53 citation statements)

References 380 publications

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“…13 Although diabetes is the most reported condition related to a high incidence of hypogonadism, many chronic illnesses are reported to be accompanied by a substantial incidence of low testosterone levels. 3,[14][15][16][17][18] Guay et al 19 have reported a prevalence of hypogonadism of 36.0% in men with ED seen in an endocrinology specialty center for sexual function and dysfunction. The majority of the men, 62.0%, had a pure organic cause for their ED, whereas 28.2% had mixed organic-psychological causes and 9.8% had pure psychological causes.…”

Section: Introductionmentioning

confidence: 99%

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

2009

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The prevalence of hypogonadism has been found to be increased in certain chronic illnesses, especially diabetes, hypertension and obesity. Recently, the prevalence of hypogonadism in primary care practices mirrored that in our population of men with erectile dysfunction (ED). In this study, the prevalence of hypogonadism in nearly 1000 men with ED was tabulated, using a retrospective chart review, and analyzed for association with the various contributing medical and psychological factors. The prevalence of hypogonadism was determined in men with a variety of chronic illnesses, and was further characterized by decade. We observed an association between hypertension (P ¼ 0.025), tobacco abuse (P ¼ 0.0059), sleep apnea (P ¼ 0.0001), work stress (P ¼ 0.041) and hypogonadism. These data were further analyzed for the odds ratio and confidence interval (Forest plot), which showed strong association for sleep apnea and work stress. We did not observe any significant association between diabetes, atherosclerosis, alcohol abuse, multiple medications, asthma, seizure disorder, anxiety/depression and hypogonadism (P values for Cochran-Mantel-Haenszel general association were 0. 48, 0.97, 0.25, 0.69, 0.22, 0.76 and 0.98, respectively). We suggest that a host of chronic illnesses have a high prevalence of secondary hypogonadism. Men who have chronic medical or psychological illnesses should have their testosterone level checked, especially when sexual dysfunction symptoms or signs are present.

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Section: Introductionmentioning

confidence: 99%

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

2009

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“…Transient decreases in serum T, such as caused by acute illness, can be ruled out by repeated hormone measurements. 12 Measurement of SHBG, FT and oestradiol are currently not indicated for screening but can be helpful when suspicion of LOH persists despite borderline or normal serum total T. A FT level below 65 pg/ml can be construed as indication for T treatment. Measurement of LH and prolactin may assist in differentiating between primary and secondary hypogonadism; these tests are recommended when secondary hypogonadism is suspected or when T is lower than 150 ng/dl.…”

Section: Late Onset Hypogonadism (Loh)mentioning

confidence: 98%

“…[9][10][11] This decline in serum T levels is caused by a decrease in the number of Leydig cells in the testes, as well as a decline in responsiveness to stimulation with luteinizing hormone (LH). 12,13 In addition to a decline in the production of T in older men, the level of bioavailable T (BT) declines due to increases in SHBG concentration at an average of 1.2% annually. 10,14 In the MMAS, serum T values below 251, 216, 196 and 156 ng/dl were representative of the lowest 2.5th percentile for men in their 40s, 50s, 60s and 70s, respectively.…”

Section: Age-related Variations In Serum Testosterone Levelsmentioning

confidence: 99%

“…The influence of T on sexual functioning is most pronounced in the case of young men with serum T levels below or near the lower limit of the normal young adult range. 12 T exerts effects on libido at the level of the central nervous system, more specifically in the hypothalamic preoptic area and the arcuate nucleus. Peripherally, T plays a critical role in erectile function by maintaining penile tissue integrity, structure and function of pelvic ganglion neurons, and in the expression of nitric oxide synthase (NOS) isoforms.…”

Section: Physiology/pathophysiology Of Testosterone and Sexual Functionmentioning

confidence: 99%

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Sexual dysfunction in the older man

Albersen

Shindel

Lue

2009

Rev. Clin. Gerontol.

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Age is strongly associated with risk of sexual dysfunction in both men and women. For many years it was assumed that such a loss of sexuality was natural and inevitable, and therefore little attention was given to sexual behaviour and treatment in this population. However, more recent data have suggested that sexuality remains important into later life for many individuals. Although appreciation of sexuality persists, a decline in sexual activity is typical with advancing age, which is in part attributable to both general health problems and specific sexual dysfunctions, both becoming more prevalent with ageing. The principle sexual health issues in older men include erectile dysfunction and late onset hypogonadism. Although premature ejaculation is prevalent in older men, the bother from this disorder is generally lower in older men. This manuscript consists of a review of the contemporary peer-reviewed literature and attempts to provide insights for the physician treating the geriatric population. We discuss sexual behaviour at older age, and address erectile and androgen biology in older men and the prevalence and aetiology of sexual dysfunction in this population. Furthermore, an overview of contemporary pharmacological treatments for older men's sexual problems is provided.

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“…It is generally well accepted that libido, frequency of sexual activity, and spontaneous (morning, nocturnal) erections are all testosterone dependent. Support for this comes from studies on hypogonadal men treated with testosterone replacement therapy [59]. Testosterone exerts its effects on erectile function in a number of ways.…”

Section: Testosterone Deficiency Metabolic Syndrome and Edmentioning

confidence: 99%

Erectile Dysfunction and Cardiovascular Disease: A Review

2013

J Androl Gynaecol

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Hormones, Metabolism, Aging and Men's Health

Cited by 22 publications

References 380 publications

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

Hypogonadism in men with erectile dysfunction may be related to a host of chronic illnesses

Sexual dysfunction in the older man

Erectile Dysfunction and Cardiovascular Disease: A Review

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