Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test

Magen, Eli; Mishal, Joseph; Schlesinger, Menachem; Scharf, Shimon

doi:10.1111/j.1523-5378.2007.00522.x

Cited by 51 publications

(45 citation statements)

References 20 publications

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“…[7] Another study showed that eradication of HP infection by triple therapy signiÞ cantly and equally reduces urticarial activity score in CU patients with positive and negative autologous serum test. [11] The discrepancy between results of these different studies may be due to the different [12] Once this occurs the production of IgE antibodies responsible for urticarial symptoms might continue even after eradication of HP. [12] Thus HP infection may perpetuate the urticarial tendency of an infected person.…”

Section: Discussionmentioning

confidence: 99%

Chronic urticaria and Helicobacter pylori

Yadav¹,

Rishi²,

Nijawan³

2008

Indian J Med Sci

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Section: Discussionmentioning

confidence: 99%

Chronic urticaria and Helicobacter pylori

Yadav¹,

Rishi²,

Nijawan³

2008

Indian J Med Sci

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“…Tab. 2; [23,27,35,65]). In diesen Studien wurde der Eradikationserfolg 4-6 Wochen nach Therapie überprüft und nur Patienten mit gesicherter Eradikation wurden hinsichtlich ihrer Urtikaria evaluiert.…”

Section: Gastrointestinale Infekteunclassified

“…In diesen Studien wurde der Eradikationserfolg 4-6 Wochen nach Therapie überprüft und nur Patienten mit gesicherter Eradikation wurden hinsichtlich ihrer Urtikaria evaluiert. In 2 Studien wurden anerkannte UrtikariaAktivitätsscores und/oder standardisierte Instrumente zur Erfassung der Lebensqualität (CU-Q 2 ol) eingesetzt [35,65].…”

Section: Gastrointestinale Infekteunclassified

Infektfokus und chronische spontane Urtikaria

et al. 2010

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Urticaria represents a common skin reaction pattern that can be induced by different factors. Triggering by infections has been discussed for many years but the exact role and mechanism of mast cell activation by infectious processes is unclear. In acute spontaneous urticaria, there is no doubt about a causal relationship to infections and all chronic urticaria must start as acute. Remission of annoying spontaneous chronic urticaria has been reported after successful treatment of persistent infections. Summarizing available studies evaluating the course after proven Helicobacter eradication demonstrates a statistically significant benefit compared to not-eradicated or Helicobacter-negative patients. The licensed treatment with a standard dose of H1-antihistamines is not effective in a significant number of patients and infections can be easily treated. Therefore, appropriate diagnostic procedures should be included in the routine work-up, especially the search for Helicobacter pylori.

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“…In contrast, studies have found that evidence for a reported benefit of H. pylori eradication was weak and conflicting, eradication therapy may itself trigger urticaria, and the stated benefits might have been from eradication of other undiagnosed/asymptomatic infections [15,16]. Various mechanisms have been speculated to explain the possible association of H. pylori with chronic urticaria [9][10][11][16][17][18]. H. pylori is suggested to increase the secretion of gastric acid and pepsin, which induces active inflammation in the gastrointestinal tract leading to the recruitment of neutrophils, eosinophils, and lymphocytes, which release a family of histamine-releasing factors that induce mast cell degranulation.…”

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confidence: 90%

Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical Helicobacter pylori Infection: A Cross-Sectional Study of 150 Patients

Kohli¹,

Mahajan²,

Rana³

et al. 2018

Int Arch Allergy Immunol

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Background: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. Methods: Endoscopic antral biopsy for the rapid urease test (RUT) and histopathology, and serum IgG ELISA for H. pylori infection were performed in 150 patients (male:female ratio 1:2.4) of chronic urticaria aged 18-68 years. Clinicoepidemiologic features including age, gender, age of onset and duration, frequency and distribution of wheals, urticaria severity score, and systemic symptoms were analyzed in patients with and without H. pylori. The results of serum IgG ELISA for H. pylori were compared with 106 age- and gender-matched healthy adult controls. Results: The RUT in 84 patients (56%), histopathology in 76 patients (50.6%), and H. pylori IgG ELISA in 94 patients (62.6%) were positive. H. pylori IgG ELISA was positive only in 35 (33%) controls, suggesting that chronic urticaria patients were more likely to have asymptomatic H. pylori infection than normal controls. Although not statistically significant, patients with H. pylori had a higher mean urticaria severity score, number of urticaria/angioedema episodes per year, and involvement of more body sites, particularly the scalp, palms, and soles. The constitutional or gastrointestinal symptoms were statistically higher in patients with H. pylori infection than those without it. Conclusion: A subset of chronic urticaria patients appears to have asymptomatic H. pylori infection. However, its implications in chronicity, recurrences, the severity of urticaria, other systemic manifestations, and management remains conjectural in view of 33% of controls also having positive H. pylori ELISA and the endemicity of infection in developing countries.

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Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test

Abstract: Eradication of H. pylori infection by triple therapy significantly and equally reduces UAS in CU patients with positive and negative ASST.

Cited by 51 publications

References 20 publications

Chronic urticaria and <i>Helicobacter pylori</i>

Chronic urticaria and <i>Helicobacter pylori</i>

Infektfokus und chronische spontane Urtikaria

Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical <b><i>Helicobacter pylori</i></b> Infection: A Cross-Sectional Study of 150 Patients

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