“…The demographic profile of the 150 patients in this study corroborates with descriptions in the dermatology literature [1][2][3]. An etiopathogenetic link between H. pylori infection and chronic urticaria and possible improvements after its eradication has been demonstrated.…”
Section: Discussionsupporting
confidence: 70%
“…However, a greater number (96 vs. 15) of patients with positive test results had a significantly higher (p < 0.05) mean number of systemic symptoms than patients with negative results. Furthermore, the prevalence of H. pylori-associated gastrointestinal symptoms remains variable, from being symptomatic to the complete absence of symptoms [2,8,10,28]. In their 57% urticaria patients with positive H. pylori, Abdou et al [10] reported no gastric symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…It affects women more often than men and usual onset is between 20 and 40 years of age [1][2][3]. Its etiology often remains unestablished despite extensive investigative workup rendering causespecific management difficult.…”
mentioning
confidence: 99%
“…H. pylori as an antigen may also induce the expression of certain epitopes on endothelial cell adhesion molecules. H. pylori is also speculated to produce IgE antibodies by its cross-reaction with parietal cells that may encourage the release of histamine in the skin, causing wheal formation [2,19]. The antibodies (IgG, IgA) also demonstrated against 19-kDa H. pylori protein probably contribute to the pathogenesis of chronic urticaria by excessive consumption of complement.…”
Background: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. Methods: Endoscopic antral biopsy for the rapid urease test (RUT) and histopathology, and serum IgG ELISA for H. pylori infection were performed in 150 patients (male:female ratio 1:2.4) of chronic urticaria aged 18-68 years. Clinicoepidemiologic features including age, gender, age of onset and duration, frequency and distribution of wheals, urticaria severity score, and systemic symptoms were analyzed in patients with and without H. pylori. The results of serum IgG ELISA for H. pylori were compared with 106 age- and gender-matched healthy adult controls. Results: The RUT in 84 patients (56%), histopathology in 76 patients (50.6%), and H. pylori IgG ELISA in 94 patients (62.6%) were positive. H. pylori IgG ELISA was positive only in 35 (33%) controls, suggesting that chronic urticaria patients were more likely to have asymptomatic H. pylori infection than normal controls. Although not statistically significant, patients with H. pylori had a higher mean urticaria severity score, number of urticaria/angioedema episodes per year, and involvement of more body sites, particularly the scalp, palms, and soles. The constitutional or gastrointestinal symptoms were statistically higher in patients with H. pylori infection than those without it. Conclusion: A subset of chronic urticaria patients appears to have asymptomatic H. pylori infection. However, its implications in chronicity, recurrences, the severity of urticaria, other systemic manifestations, and management remains conjectural in view of 33% of controls also having positive H. pylori ELISA and the endemicity of infection in developing countries.
“…The demographic profile of the 150 patients in this study corroborates with descriptions in the dermatology literature [1][2][3]. An etiopathogenetic link between H. pylori infection and chronic urticaria and possible improvements after its eradication has been demonstrated.…”
Section: Discussionsupporting
confidence: 70%
“…However, a greater number (96 vs. 15) of patients with positive test results had a significantly higher (p < 0.05) mean number of systemic symptoms than patients with negative results. Furthermore, the prevalence of H. pylori-associated gastrointestinal symptoms remains variable, from being symptomatic to the complete absence of symptoms [2,8,10,28]. In their 57% urticaria patients with positive H. pylori, Abdou et al [10] reported no gastric symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…It affects women more often than men and usual onset is between 20 and 40 years of age [1][2][3]. Its etiology often remains unestablished despite extensive investigative workup rendering causespecific management difficult.…”
mentioning
confidence: 99%
“…H. pylori as an antigen may also induce the expression of certain epitopes on endothelial cell adhesion molecules. H. pylori is also speculated to produce IgE antibodies by its cross-reaction with parietal cells that may encourage the release of histamine in the skin, causing wheal formation [2,19]. The antibodies (IgG, IgA) also demonstrated against 19-kDa H. pylori protein probably contribute to the pathogenesis of chronic urticaria by excessive consumption of complement.…”
Background: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. Methods: Endoscopic antral biopsy for the rapid urease test (RUT) and histopathology, and serum IgG ELISA for H. pylori infection were performed in 150 patients (male:female ratio 1:2.4) of chronic urticaria aged 18-68 years. Clinicoepidemiologic features including age, gender, age of onset and duration, frequency and distribution of wheals, urticaria severity score, and systemic symptoms were analyzed in patients with and without H. pylori. The results of serum IgG ELISA for H. pylori were compared with 106 age- and gender-matched healthy adult controls. Results: The RUT in 84 patients (56%), histopathology in 76 patients (50.6%), and H. pylori IgG ELISA in 94 patients (62.6%) were positive. H. pylori IgG ELISA was positive only in 35 (33%) controls, suggesting that chronic urticaria patients were more likely to have asymptomatic H. pylori infection than normal controls. Although not statistically significant, patients with H. pylori had a higher mean urticaria severity score, number of urticaria/angioedema episodes per year, and involvement of more body sites, particularly the scalp, palms, and soles. The constitutional or gastrointestinal symptoms were statistically higher in patients with H. pylori infection than those without it. Conclusion: A subset of chronic urticaria patients appears to have asymptomatic H. pylori infection. However, its implications in chronicity, recurrences, the severity of urticaria, other systemic manifestations, and management remains conjectural in view of 33% of controls also having positive H. pylori ELISA and the endemicity of infection in developing countries.
“…Recent studies from various groups indicate that H. pylori is associated with a variety of extragastric disorders such as type 2 diabetes mellitus [7,8], dermatological disorders such as scleroderma [9], rosacea [10], psoriasis [11], chronic idiopathic urticaria [12,13], primary Raynaud's phenomenon [14,15], migraine [16], Guillain-Barre syndrome [17], acute inflammatory demyelinating polyradiculoneuropathy [18], chronic idiopathic thrombocytopenic purpura [19,20], cardiovascular risk factors such as acute coronary ischemia [21] and chronic recurrent abdominal pain [22][23][24]. The cause of vitamin B 12 deficiency, iron deficiency, and vitamin B 12 /iron deficiency anemia in children has also been linked to H. pylori infection [25][26][27][28].…”
Section: Association Of H Pylori With Other Diseasesmentioning
Helicobacter pylori (H. pylori) infection, quite prevalent in the developing countries, is considered to be one of the causative factors for various gastric pathologies and other nongastric diseases. It is believed that H. pylori infection is almost always acquired in early childhood and persists throughout life unless specific treatment is given. The (13/14)C-urea breath test (UBT) is now considered to be a 'gold standard' technique for the detection of H. pylori infection. However, because of the lack of facilities and high cost, the preferred nonradioactive ¹³C-UBT cannot be performed on pediatric patients in developing countries, whereas the radioactive ¹⁴C-UBT is not used on children because of the fear of radiation exposure. When using 37 kBq (1 μCi) of ¹⁴C-urea for the ¹⁴C-UBT, the patient is not exposed to more radiation than is acquired from the natural environment in one day, as almost all the ingested radioactivity is excreted from the body (urine and breath) within 72-120 h. This article reviews the importance of the ¹⁴C-UBT for the detection of H. pylori and justifies the radiation safety aspects of its use in children without any fear of 'radiation phobia' where the facility for ¹³C-UBT is lacking.
Urticaria represents a common skin reaction pattern that can be induced by different factors. Triggering by infections has been discussed for many years but the exact role and mechanism of mast cell activation by infectious processes is unclear. In acute spontaneous urticaria, there is no doubt about a causal relationship to infections and all chronic urticaria must start as acute. Remission of annoying spontaneous chronic urticaria has been reported after successful treatment of persistent infections. Summarizing available studies evaluating the course after proven Helicobacter eradication demonstrates a statistically significant benefit compared to not-eradicated or Helicobacter-negative patients. The licensed treatment with a standard dose of H1-antihistamines is not effective in a significant number of patients and infections can be easily treated. Therefore, appropriate diagnostic procedures should be included in the routine work-up, especially the search for Helicobacter pylori.
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