Eradication of <i>Helicobacter pylori</i> Infection Improves Blood Pressure Values in Patients Affected by Hypertension

Migneco, Alessio; Ojetti, Veronica; L, Specchia; Franceschi, Francesco; Candelli, Marcello; Mettimano, Marco; Montebelli, Rita; Savi, L; Gasbarrini, Giovanni

doi:10.1111/j.1523-5378.2003.00180.x

Cited by 59 publications

(47 citation statements)

References 26 publications

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“…It has been reported that H. pylori eradication improves BP values in patients affected by hypertension. The link between hypertensive disease and H. pylori was related to a possible activation of the cytokine cascade with the release of vasoactive substances from the primary site of H. pylori colonization [11-13]. …”

Section: Discussionmentioning

confidence: 99%

“…A possible association between H. pylori and cardiovascular disorders has been found. The release of cytotoxic substances either of a bacterial origin or produced by the host may represent mediators of these systemic sequelae [11]. Different reports have confirmed the development and association of cytotoxin-associated gene A (cagA) positive H. pylori strains with many clinical problems.…”

Section: Introductionmentioning

confidence: 99%

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An Alternative Approach for the Rising Challenge of Hypertensive Illness via Helicobacter pylori Eradication

Nasrat

Nasrat²

2015

Cardiol Res

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BackgroundThe aim of the study was to demonstrate the effect of natural Helicobacter pylori eradication on blood pressure values. The prevalence of hypertension in developing countries has been considered by some reports a consequence of progress and life style changes. In spite of that, traditional risk factors do not appear fully sufficient to explain the rising figures of hypertensive illness which further indicates that attempts to control the problem depending upon traditional measures can never be adequate or decisive. H. pylori could migrate or get forced to migrate to the colon; it will continue producing ammonia for a reason or no reason leading to accumulation of profuse toxic amounts of ammonia, unopposed or buffered by any acidity, which could lead to multiple colonic and a high rectal spasm. A colonic re-absorptive error is established with excessive fluid and salt retention in the body that would definitely lead to hypertension which is supposed to remain inadequately controlled without correction of the underlying etiologic pathological error. It is a prospective study, conducted at Balghsoon Polyclinic, Jeddah, Saudi Arabia.MethodsNinety-nine middle-aged male patients with essential hypertension under medications and positive for H. pylori dyspepsia were included in the study. They were given natural therapy for H. pylori eradication.ResultsNinety patients were able to resume normal blood pressure (BP) values and quit their medications.ConclusionThe concept of the colonic re-absorptive error considered in this study is not just hypothetical as upon its basis, most patients of the study (90.9%) were able to quit medications and maintain normal BP values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Alternative Approach for the Rising Challenge of Hypertensive Illness via Helicobacter pylori Eradication

Nasrat

Nasrat²

2015

Cardiol Res

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“…The association between H.pylori infection and elevated blood pressure is controversial [13,14], but it seems that H.pylori eradication could improve blood pressure especially in hypertensive patients [15]. The hypotensive effect of broccoli sprouts is also controversial; supplementation of spontaneously hypertensive stroke-prone rat with broccoli sprouts significantly decreased blood pressure [16], while ingestion of broccoli sprouts had not significant effect on blood pressure and endothelial function measured by flow mediated dilation in hypertensive patients [17].…”

Section: Discussionmentioning

confidence: 99%

A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes

Mirmiran

Bahadoran

Golzarand

et al. 2014

J Diabetes Metab Disord

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BackgroundIn this clinical trial we compared the effects of broccoli sprouts powder, as an alternative and complementary treatment, to those of standard triple therapy, as a common medical treatment, on cardiovascular risk factors following the H.pylori eradication in patients with type 2 diabetes.MethodsEighty-six type 2 diabetic patients with positive H.pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: STT) Standard triple therapy (omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg, twice a day for 14 days), BSP) 6 g/d broccoli sprouts powder for 28 days, and combination of these as STT + BSP. After 4 weeks of treatment, H.pylori eradication rates were assessed by HpSAg. Anthropometric measures, blood pressure, serum lipids and lipoproteins as well as serum high sensitive- C reactive protein were also assessed at baseline and at the second examination.ResultsSeventy-seven participants completed the study [STT (n = 28), BSP (n = 25), STT + BSP (n = 24)]. The H.pylori eradication rates were 89.3%, 56.0% and 91.7% in STT, BSP and STT + BSP groups, respectively. After the treatment, both systolic and diastolic blood pressure significantly decreased in STT + BSP group (P < 0.05). Serum triglycerides and TG/HDL-C ratio increased in STT patients group (<0.05). Serum hs-CRP levels significantly decreased in the patients who were treated with BSP per se (3.0 ± 2.5 at baseline vs. 2.3 ± 2.1 after the treatment, P < 0.05).ConclusionCompared to standard triple therapy, BSP regimen in addition to considerable effects on H.pylori eradication had also favorable properties on cardiovascular risk factors following the H.pylori eradication.

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“…Individual measures worsened with known or presumed eradication failure (efficacy study): breadth‐of‐base tended to narrow with known eradication failure, visual dependency increased in the ANA positive. Supine mean arterial pressure fell progressively following Helicobacter eradication [53], with a corresponding rise in pulse rate (case history): obesity and fluid retention, associated with elevated serum cortisol [46], may have contributed to initial pressures. Pulse fell with known failure.…”

Section: Discussionmentioning

confidence: 99%

Differential Effect of Helicobacter pylori Eradication on Time‐Trends in Brady/Hypokinesia and Rigidity in Idiopathic Parkinsonism

Dobbs

Weller

et al. 2010

Helicobacter

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Background:We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication-therapy failed, prompted an interim report in the first 20 probands to reach de-blinding. The null-hypothesis, “eradication has no effect on principal outcome, mean stride length at free-walking speed,” was rejected. We report on study completion in all 30 who had commenced post-treatment assessments.Methods:This is a randomized, placebo-controlled, parallel-group efficacy study of eradicating biopsy-proven (culture and/or organism on histopathology) Helicobacter pylori infection on the time course of facets of IP, in probands taking no, or stable long-t½, anti-parkinsonian medication. Persistent infection at de-blinding (scheduled 1-year post-treatment) led to open active eradication-treatment.Results:Stride length improved (73 (95% CI 14–131) mm/year, p = .01) in favor of “successful” blinded active over placebo, irrespective of anti-parkinsonian medication, and despite worsening upper limb flexor rigidity (237 (57–416) Nm × 10−3/year, p = .01). This differential effect was echoed following open active, post-placebo. Gait did not deteriorate in year 2 and 3 post-eradication. Anti-nuclear antibody was present in all four proven (two by molecular microbiology only) eradication failures. In the remainder, it marked poorer response during the year after eradication therapy, possibly indicating residual “low-density” infection.We illustrate the importance of eradicating low-density infection, detected only by molecular microbiology, in a proband not receiving anti-parkinsonian medication. Stride length improved (424 (379–468) mm for 15 months post-eradication, p = .001), correction of deficit continuing to 3.4 years. Flexor rigidity increased before hydrogen-breath-test positivity for small intestinal bacterial overgrowth (208 (28–388) Nm × 10−3, p = .02), increased further during (171 (67–274), p = .001) (15–31 months), and decreased (136 (6–267), p = .04) after restoration of negativity (32–41 months).Conclusion:Helicobacter is an arbiter of progression, independent of infection-load.

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Eradication of Helicobacter pylori Infection Improves Blood Pressure Values in Patients Affected by Hypertension

Cited by 59 publications

References 26 publications

An Alternative Approach for the Rising Challenge of Hypertensive Illness via Helicobacter pylori Eradication

An Alternative Approach for the Rising Challenge of Hypertensive Illness via Helicobacter pylori Eradication

A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes

Differential Effect of Helicobacter pylori Eradication on Time‐Trends in Brady/Hypokinesia and Rigidity in Idiopathic Parkinsonism

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