A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes

Abstract

BackgroundIn this clinical trial we compared the effects of broccoli sprouts powder, as an alternative and complementary treatment, to those of standard triple therapy, as a common medical treatment, on cardiovascular risk factors following the H.pylori eradication in patients with type 2 diabetes.MethodsEighty-six type 2 diabetic patients with positive H.pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: STT) Standard triple therapy (omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg, twice a day for 14 days), BSP) 6 g/d broccoli sprouts powder for 28 days, and combination of these as STT + BSP. After 4 weeks of treatment, H.pylori eradication rates were assessed by HpSAg. Anthropometric measures, blood pressure, serum lipids and lipoproteins as well as serum high sensitive- C reactive protein were also assessed at baseline and at the second examination.ResultsSeventy-seven participants completed the study [STT (n = 28), BSP (n = 25), STT + BSP (n = 24)]. The H.pylori eradication rates were 89.3%, 56.0% and 91.7% in STT, BSP and STT + BSP groups, respectively. After the treatment, both systolic and diastolic blood pressure significantly decreased in STT + BSP group (P < 0.05). Serum triglycerides and TG/HDL-C ratio increased in STT patients group (<0.05). Serum hs-CRP levels significantly decreased in the patients who were treated with BSP per se (3.0 ± 2.5 at baseline vs. 2.3 ± 2.1 after the treatment, P < 0.05).ConclusionCompared to standard triple therapy, BSP regimen in addition to considerable effects on H.pylori eradication had also favorable properties on cardiovascular risk factors following the H.pylori eradication.

Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds

“…In addition, due to its antioxidant and anti-inflammatory properties, it has a beneficial effect on the cardiovascular system, which has been confirmed by both in vitro and animal studies. Mirmiran et al [ 77 ] have shown that broccoli extract and other products with a high GR content reduce the plasma low-density lipoprotein (LDL) cholesterol, but the mechanism of this interaction is not yet known.…”

Isothiocyanates: Translating the Power of Plants to People

“…Cardiovascular disease risk in Helicobacter pylori -infected T2D patients was shown to be reduced after administration of broccoli sprouts powder [75]. However, in 40 hypertension patients consuming 10 g of dried broccoli sprouts for 4 weeks, no changes in blood pressure or flow mediated dilation were detected [76].…”

“…In 2015, a study showed that a broccoli diet containing high levels of GR reduced plasma LDL cholesterol levels significantly . Cardiovascular disease risk in H. pylori ‐infected T2D patients was shown to be reduced after administration of broccoli sprouts powder . However, in 40 hypertension patients consuming 10 g of dried broccoli sprouts for 4 weeks, no changes in blood pressure or flow‐mediated dilation were detected .…”

Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging

“…The preventing effect of sinigrin may be due to the ability to suppress the production of inflammatory cytokines and the expression of pro-atherogenic factors in serum, aorta, and liver tissue [inhibits the VCAM-1 expression via preventing NF-κB and p38 MAPK/JNK pathways in MOVAS cells] [7]. Clinical trials that have used isothiocyanate supplementation by increasing food consumption with high concentration of these compounds, shown a decrease in LDL levels and an improvement in blood pressure control [152,153]. Recently, in a rabbit model of cardiac failure, the supplementation with Sulforaphane [0.5 mg/kg in a subcutaneous dose for five days per twelve-week] improved ventricular cardiac function and remodeling by inhibiting oxidative stress and inflammation with a possible mitochondrial role [154].…”