Er(OTf)₃ Assisted Efficient Synthesis of 3‐Hydroxynaphthalene‐1, 4‐Dione Derivatives via Pseudo Four‐Component Reactions and Their Biological Evaluation

Abstract

A green, operationally simple and highly efficient one pot fourcomponent approach for the synthesis of 2-hydroxy-3-((5hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(phenyl)methyl) naphthalene-1,4-dione derivatives has been developed by a domino reaction. Ethyl acetoacetate, aromatic aldehyde, 2hydroxynaphthaquinoline and phenylhydrazine derivative was used as the reagent and Er(OTf) 3 as the catalyst. This approach offers the advantages of clean and simple methodology, short reaction time, no column purification, low environmental impact, simple isolation of product and good yield. The synthesized compounds (5a-o) were screened for in vitro antioxidant and anti-inflammatory activities and the results were compared with standards.

One Pot Synthesis and Characterization of Palladium [Pd(Anil-Tolu)4(H2O)2]by insitu Method

“…These spectra were confirmed the formation of metal complexes successfully using in-situ preparation at room temperature. These spectra were confirmed that the formation of (Anil-Tolu) 4 and [Pd(Anil-Tolu) 4 (H 2 O) 2 ] successfully by in-situ method. Figure 2 shows the FT-IR spectra of (Anil-Tolu) 4 (a) and its metal complexe [Pd(Anil-Tolu) 4 The bands at 2800-3000 cm-1 due to the stretching of ν(C-H) and the band at ~1598 cm-1 due to the stretching vibration of ν(C=C) and the responses of aldehyde ν(C-H) obtained at 1309 cm-1.…”

“…These spectra were confirmed that the formation of (Anil-Tolu) 4 and [Pd(Anil-Tolu) 4 (H 2 O) 2 ] successfully by in-situ method. Figure 2 shows the FT-IR spectra of (Anil-Tolu) 4 (a) and its metal complexe [Pd(Anil-Tolu) 4 The bands at 2800-3000 cm-1 due to the stretching of ν(C-H) and the band at ~1598 cm-1 due to the stretching vibration of ν(C=C) and the responses of aldehyde ν(C-H) obtained at 1309 cm-1. Some of the bands of metal complexes are observed at slightly lower region compared with pure ligand, which confirms the metals were coordinated with Schiff base ligand.…”

“…The most of the schiff base and its metal complexes are synthesized using condensation reaction, which are having the C=N functional group in it and which are synthesized usually by the reaction of amine and aldehyde [1,2]. For the past few decades, these kind of metal complexes play a vital role in various fields such as pharmacy companies, life sciences, chemical science especially inorganic and analytical field and also medical industries and it has display a broad range of utilization in various fields like antitumor, antibacterial and antifungal activity [3][4][5][6][7][8]. The presence of bulkier group in its structure having the steric hindrance and its stabilization of complexes by its metal oxidation state and it has very good solubility for the further spectral analysis to confirm the formation of metal complex [9][10][11][12][13][14][15].…”

Application of cobalt phthalocyanine as a nanostructured catalyst in the synthesis of biological henna‐based compounds

“…A number of processes have been reported for the syntheses which includes 1‐butyl‐3‐methylimidazolium hydroxide . HOAc under microwave irradiation, [Pyrr][HCOO], DABCO, DBU, Er (OTf) 3 , water under MW, [DBU] 2 [EDS], (4‐sulfobutyl)tris(4‐sulfophenyl) phosphonium hydrogen sulfate, Nano‐Fe 3 O 4 /PEG/succinic anhydride, phenylphosphinic acid, p ‐TSA …”

Synthesis and Characterization of [Sa(p-anisal-DA)4(H2O)2]by insitu Method

“…Recently, the Schiff bases and complexes were significant in various in pharmaceutical and medicinal field. They display a broad range of biological applications such as antitumor, antifungal, antiviral and antibacterial activity [1][2][3][4][5][6][7][8][9] and also these types of complexes having higher steric hindrance nature by introducing the bulkier substituent in its existing molecules. The stabilization of metal complexes by its metal oxidation nature and it gives good solubility for the spectrum analysis [10][11][12].…”