Equivalent Therapeutic Efficacy and Safety of Ivermectin and Lindane in the Treatment of Human Scabies

Chouela, Edgardo; Abeldaño, Alejandra; Pellerano, Graciela; Forgia, Marta La; Papale, Rosa María; Garsd, Armando; Balian, María del Carmen; Battista, Viviana; Poggio, Nora

doi:10.1001/archderm.135.6.651

Cited by 107 publications

(57 citation statements)

References 12 publications

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“…Ivermectin is a comparatively cheap drug, and its use has been suggested in individuals infected with intestinal helminths and ectoparasites when specific diagnoses are difficult to establish due to lack of appropriate health infrastructure (Chouela et al 1999, Madan et al 2001, Brooks & Grace 2002, Buffet & Dupin 2003, head lice (Glaziou et al 1994), and cutaneous larva migrans (Caumes 2003) with no significant adverse events. Ivermectin is contraindicated for children younger than five years of age or less than 15 kg body weight because of the ongoing uncertainty of possible neuro-toxicity of the drug and in view of the not yet fully developed bloodbrain barrier in small children (Edwards 2003).…”

Section: Discussionmentioning

confidence: 99%

Therapy of tungiasis: a double-blinded randomized controlled trial with oral ivermectin

Heukelbach

Franck

Feldmeier

2004

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Therapy of tungiasis: a double-blinded randomized controlled trial with oral ivermectin

Heukelbach

Franck

Feldmeier

2004

Mem. Inst. Oswaldo Cruz

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“…5,9 Chouela et al, found the cure rate of scabies at 15th day, after treatment with ivermectin single dose of (150 -200 µg/kg) to be 74%. 10 …”

Section: Oral Ivermectin (200 µG/kg Body Weight Single Dose)mentioning

confidence: 99%

“…Taplin et al, Zargari M et al, Chouela et al, have found 65%, 48.9%, 44.44%, 54% cure rate respectively with 1% lindane lotion after 1 month. [10][11][12]14 Comparison of statistical significance among three groups Difference in efficacy of group I (ivermectin) therapy was statistically non-significant with group II (permethrin) but statistically significant with group III (gama benzene hexachloride). This shows that efficacy of group I therapy was comparable to group II therapy but more efficacious than group III therapy.…”

Section: Topical Permethrin 5% Lotion (Single Application)mentioning

confidence: 99%

Study of efficacy of oral ivermectin in comparison to commonly used topical antiscabetic drugs gamma benzene hexachloride and permethrin

Kanwar

Mathur

Sankhla

2016

Int J Basic Clin Pharmacol

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“…Especialmente útil es en lesiones extensas de piel, pacientes inmunosuprimidos que presentan sarna costrosa, infecciones bacterianas concomitantes, situaciones en las que las formulaciones tópicas pueden ser dolorosas para los pacientes lo que lleva a baja adherencia al tratamiento 25 . Ivermectina tiene una respuesta clínica cercana a 70% si se utiliza en dosis única; sin embargo, al administrar dos dosis espaciadas por una semana en el tratamiento de escabiosis puede presentar tasas de curación de 97 a 100% 26,27 . Otro reporte mostró una respuesta variable a ivermectina oral en pacientes con sarna costrosa 28 .…”

Section: Escabiosisunclassified

Ectoparasitosis de importancia en Chile: Epidemiología y terapia

2011

Rev. chil. infectol.

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Several parasitic diseases affect the skin and appendages in humans, the most common are head lice and scabies. Both diseases have worldwide distribution with geographical variations. In Chile, the reported prevalence of head lice is 20-25% and of scabies 1-5%. Other ectoparasites include fl eas and mite, causing transient parasitosis related to human and animal contact. These parasites are associated with various factors such as poor personal hygiene, promiscuity, long hair, crowding, and sharing of combs, among others. Various effective pharmacological therapies are available, which base on several active compounds. Important therapeutic options include topical treatments with pyrethroids, lindane, crotamiton, and malathion as well as oral medications such as ivermectin, which is used in case of drug intolerance, poor treatment response, infections with multiple parasites or concomitant bacterial infections. For some drugs, resistance has been reported in patients received multiple dosis.Key words: Head lice, scabies, prevalence, ivermectin. Palabras clave: Pediculosis, escabiosis, sarna, prevalencia, ivermectina. Departamento deMicrobiología, Universidad de Chile. Declaración de conflictos de interés:Sin conflictos.Fuente de financiamiento: La presente publicación no tiene financiamiento externo. Recibido: 6 de julio de 2010Aceptado: 16 de mayo de 2011Correspondencia a:Introducción L os ectoparásitos han afectado al hombre desde la antigüedad, siendo altamente prevalentes y transmisibles. Existen varios parásitos capaces de comprometer la piel y fanéreos en el humano, siendo las enfermedades más frecuentes la pediculosis y la escabiosis 1 . Estos agentes se asocian a factores como escasa higiene personal, promiscuidad, uso de cabello largo, hacinamiento, intercambio de peines, entre otros 2 . Otras ectoparasitosis son la pulicosis (infestación por pulgas) y la acarosis (infestación por garrapatas), ambas transitorias, relacionadas al contacto humano y animal infestado con estos parásitos 3 . PediculosisLa pediculosis es la infestación del hombre por Pediculus humanus o piojo, agente hematófago permanente y específi co de la especie humana, que se transmite por contacto directo entre personas, afectando principalmente a niños y adolescentes. Existen dos variedades una del cuero cabelludo (P. capitis) y otra corporal (P. vestimentis o corporis). La ftirosis es la infestación por Pthirus pubis o ladilla, considerada una infección de transmisión sexual (ITS), afecta la región génito-abdominal en el adulto y cejas y/o pestañas en el niño prepúber 1 .La pediculosis capitis tiene distribución mundial. Se estima que afecta a 100 millones de personas al año, siendo los más afectados niños entre 3 y 11 años 4 . Algunos estudios describen frecuencia desde 6,8% en Turquía 5 hasta 56,7% en Israel 6 . En Latinoamérica, la prevalencia es variable. Venezuela reporta una prevalencia de 28,8%, predominando en niñas y escolares con cabello largo 7 , mientras que Argentina refi ere 56,8% de pediculosis infantil 3 .En la literatu...

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Equivalent Therapeutic Efficacy and Safety of Ivermectin and Lindane in the Treatment of Human Scabies

Cited by 107 publications

References 12 publications

Therapy of tungiasis: a double-blinded randomized controlled trial with oral ivermectin

Therapy of tungiasis: a double-blinded randomized controlled trial with oral ivermectin

Study of efficacy of oral ivermectin in comparison to commonly used topical antiscabetic drugs gamma benzene hexachloride and permethrin

Ectoparasitosis de importancia en Chile: Epidemiología y terapia

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