Equivalence of measurements of carotid stenosis. A comparison of three methods on 1001 angiograms. European Carotid Surgery Trialists' Collaborative Group.

Rothwell, Peter M.; Gibson, Rod; Slattery, J; Sellar, Robin; Warlow, C P

doi:10.1161/01.str.25.12.2435

Cited by 294 publications

(224 citation statements)

References 13 publications

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“…6 However, the cited study excluded patients with severe (Ͼ50%) stenosis on NASCET (identical to Ͼ70% on European Carotid Surgery Trial), because of the resulting secondary deformity. 6,35 We observed no difference by sex in the site of stenosis, suggesting that the earlier distinction may have been unique to the cohort evaluated.…”

Section: Discussionmentioning

confidence: 68%

Atherosclerotic Carotid Stenoses of Apical versus Body Lesions in High-Risk Carotid Stenting Patients

Park

Kim²,

Yoon³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 68%

Atherosclerotic Carotid Stenoses of Apical versus Body Lesions in High-Risk Carotid Stenting Patients

Park

Kim²,

Yoon³

et al. 2010

AJNR Am J Neuroradiol

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“…3 Stenosis data given as ECST or common carotid (CCA) diameter methods 11,72 were converted to a NASCET stenosis using the equation: NASCET = (ECST -40)/0.6. 72 Note that the same equation also converts a CCA stenosis to NASCET.…”

Section: Data Extractionmentioning

confidence: 99%

Accurate, practical and cost-effective assessment of carotid stenosis in the UK

Wardlaw

Chappell²,

Stevenson³

et al. 2006

Health Technol Assess

137

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“…At the time of the study, it was policy to operate only on patients with symptomatic carotid stenosis of at least 70% by the method used in the European Carotid Surgery Trial (equivalent to 50% NASCET method) on angiography. 25 Patients were excluded if they were undergoing surgery for restenosis or radiotherapy-induced carotid stenosis.…”

Section: Patientsmentioning

confidence: 99%

Histological Correlates of Carotid Plaque Surface Morphology on Lumen Contrast Imaging

et al. 2004

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Background-Carotid angiographic plaque surface morphology is a powerful risk factor for stroke and systemic vascular risk. However, the underlying pathology is unclear, and a better understanding is required both to evaluate other forms of carotid imaging and to develop new treatments. Previous studies comparing angiographic plaque surface morphology with pathology have been small and unblinded, and the vast majority assessed only the crude macroscopic appearance of the plaque. We performed the first large study comparing angiographic surface morphology with detailed histology. Methods and Results-Carotid plaque surface morphology was classified as ulcerated, irregular, or smooth on 128 conventional selective carotid artery angiograms from consecutive patients undergoing endarterectomy for severe symptomatic stenosis. Blinded angiographic assessments were compared with 10 histological features recorded on detailed microscopy of the plaque using reproducible semiquantitative scales. Angiographic ulceration was associated with plaque rupture (Pϭ0.001), intraplaque hemorrhage (Pϭ0.001), large lipid core (Pϭ0.005), less fibrous tissue (Pϭ0.003), and increased instability overall (Pϭ0.001). For example, angiographically ulcerated plaques were much more likely than smooth plaques to be ruptured (ORϭ15.4, 95% CIϭ2.7 to 87.3, PϽ0.001), show a large lipid core (ORϭ26.7, 95% CIϭ2.6 to 270, PϽ0.001) or a large hemorrhage (ORϭ17.0, 95% CIϭ2.0 to 147, Pϭ0.02). The equivalent odds ratios for angiographically irregular versus smooth plaque were 6.3 (1.3 to 31, Pϭ0.02), 6.7 (1.5 to 30, Pϭ0.008), and 9.2 (1.1 to 77, Pϭ0.02), respectively. Conclusions-In contrast to previous studies based on macroscopic assessment, we found very strong associations between detailed histology and carotid angiographic plaque surface morphology. Plaque surface morphology on carotid angiography is a highly sensitive marker of plaque instability. Studies of the predictive value of MR-and CT-based lumen contrast plaque surface imaging are required.

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Equivalence of measurements of carotid stenosis. A comparison of three methods on 1001 angiograms. European Carotid Surgery Trialists' Collaborative Group.

Cited by 294 publications

References 13 publications

Atherosclerotic Carotid Stenoses of Apical versus Body Lesions in High-Risk Carotid Stenting Patients

Atherosclerotic Carotid Stenoses of Apical versus Body Lesions in High-Risk Carotid Stenting Patients

Accurate, practical and cost-effective assessment of carotid stenosis in the UK

Histological Correlates of Carotid Plaque Surface Morphology on Lumen Contrast Imaging

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