Equine histoplasmosis: Treatment trial in cart horses in Central Ethiopia

Abstract

Therapeutic effects of Sodium Iodide (NaI), Potassium Iodide (KI), ground berries of "Endod" (Phytolacca dodecandra) and Penstrip were evaluated on 70 cases of equine hitoplasmosis (EH). Response to each treatment was assessed using clinical examination of the lesions. Statistically significant difference (P = 0.0036) in therapeutic effect was observed among the different remedies. Cases treated either with a combination of NaI and Penstrip (F = 6.34, P = 0.004) or "Endod" and Penstrip (F = 3.64, P = 0.031) demonstrated significant response. The difference in response to treatment between early and advanced cases of EH was statistically significant (t = 2.22, P = 0.0148).

Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum var. farciminosum and treatment of cases of epizootic lymphangitis in Ethiopia

“…Comparable results were reported with the aqueous extracts [6,7] . The present study showed that, n-butanol extract of P. dodecandra was effective against HCF.…”

“…The antifungal effect of the crude aqueous extract of P. dodecandra was demonstrated in vitro against different genera of dermatophytes of human pathogen and four clinical isolates of Candida albicans [5] . The crude aqueous extract was also found to have effect against HCF both in vitro and in vivo [6,7] . Further evaluation of different extracts of P. dodecandra on HCF isolates and cases of EL would of paramount importance towards the effort made to control EL in endemic countries.…”

“…The pus samples were inoculated onto Sabourauds dextrose agar supplemented with 2.5% glycerol and 0.5 g/L of chloramphenicol. Thereafter, the inoculated medium was incubated at 27 曟 for [6][7][8] weeks, and the growth of the fungal colony was checked continuously once a week. Then the primary colonies were sub-cultured to get pure colony.…”

Injuries and outcome of three horses hospitalised in the aftermath ofHurricaneIsaac

“…Although the mechanism of action is unknown, iodides are used as antifungal agents in horses due to their low cost and ease of administration (Carmalt et al 1999;Taintor et al 2004;Crothers et al 2009). Sodium iodide has been used successfully to treat many bacterial and fungal conditions in horses with a wide variety of dosing regimens employed (Baum et al 1984;Specht et al 1991;Chaffin et al 1992;Carmalt et al 1999;Davis et al 2000;Worster et al 2000;Lopez et al 2007;Hadush et al 2008;Crothers et al 2009). Besides sodium iodide, other systemic antifungal agents used in horses which could have been employed in Case 1 include the azoles (i.e.…”

Isolation of Histoplasma Capsulatum Var Farciminosum and other Co-Infecting Bacteria from Local Breeds of Horses with Characteristic Lesion of Epizootc Lymphangutis in Akaki and Kality Districts, Central Ethiopia

“…Healing of equine wounds particularly in the limbs is difficult due to hydrostatic factors and exposure to environmental contaminant which can lead to infection and delay healing (Tobianse et al, 2016). Bacillus, Aeromonus, Klebsiela, Staphylococcus, Micrococcus and Rhodococcus bacterial contaminants were reported in and on EL lesions (Hadush et al, 2008).…”