Equilibria Studies on Nickel(II) Complexes with 1,10-Phenanthroline Derivatives and Some Amino Acids in Aqueous Solution

İnci, Duygu; Aydın, Rahmiye

doi:10.1007/s10953-020-01046-3

Cited by 6 publications

(1 citation statement)

References 48 publications

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“…pKa values carry critical information about the complexes that ligands to be used in heavy metal removal will form with metal ions and their adsorption properties (56). While potentiometric (57) and spectrophotometric (58,59) titrations are widely used in determining pKa values of compounds, voltammetric (60), chromatographic (61,62), and nuclear magnetic resonance (NMR) spectroscopy (63) methods are also known to be used.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

EFEOĞLU,

TİKEN,

SARI

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(4-nitrobenzamide) 5 and N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(3-nitrobenzamide) 6 as bis acyl thiourea derivatives were synthesized and their molecular structures were characterized using 1H NMR, 13C NMR, COSY, DEPT, HMQC, FT-IR, and HRMS techniques. The acid dissociation constants (pKa) of the bis-acyl thiourea derivatives 5, 6 were determined potentiometrically and spectrophotometrically. The pKa values of products 5, 6 were determined in 50% (v/v) dimethyl sulfoxide–water hydro-organic solvent in the presence of 0.1 molL1 ionic strength of NaCl and in the acidic medium at 25±0.1 °C, and two pKa values were calculated for each compound with the HYPERQUAD computer program using the data obtained from the potentiometric titrations performed. In addition, three pKa values for each compound were determined in the calculations using the HypSpec program from the data obtained from the spectrophotometric titrations performed under the conditions where the potentiometric titrations were performed. For compounds 5 and 6, spectrophotometrically, pKa1 was 3.56±0.08 and 3.87±0.01, respectively, pKa2 was 7.11±0.08 and 7.05±0.01, respectively, and pKa3 was 12.30±0.08 and 11.82±0.02, respectively. It can be said that pKa1, pKa2, and pKa3 values may belong to enol, enthiol, and NH, respectively. Moreover, for compounds 5 and 6, potentiometrically, pKa2 was 7.06±0.13 and 6.94±0.11, respectively, and pKa3 was 12.11±0.06 and 11.17±0.06, respectively, and it can be said that pKa2 and pKa3 values may belong to enthiol and NH, respectively. It is seen that the pKa values determined spectrophotometrically and potentiometrically are compatible with each other.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

EFEOĞLU,

TİKEN,

SARI

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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A comprehensive study on synthesis and crystal structures of Cu(II) and Ni(II) complexes: In vitro and in silico evaluation of biomolecular interactions, antiproliferative activities and molecular docking

Özbağcı,

Erdağı,

Aydın

et al. 2024

Journal of Molecular Structure

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Protonation constants of endo- and exogenous L-amino acids and their derivatives in aqueous and mixed solution: Unraveling molecular secrets

Pająk,

Fichna,

Woźniczka

2024

Quart. Rev. Biophys.

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The aim of this review is to summarize the progress made in the determination of the protonation constants of biologically active ligands: endo- and exogenous L-amino acids and their derivatives in aqueous and mixed solutions using different experimental techniques. The knowledge of the protonation constants of the aforementioned ligands is crucial for the determination of the equilibrium constants of complex formation and thus for the understanding of complex biological reactions such as transamination, racemization, and decarboxylation. Thus, the protonation constants of ligands are a measure of their ability to form complexes with metal ions. This knowledge not only helps to understand fundamental biochemical processes, but also has practical applications in areas such as drug design, where ligands are often targeted for therapeutic purposes. The activity of the ligands tends to increase after complexation and their order is consistent with the values of the stepwise dissociation constants of the complexes formed. Understanding the properties of ligands by determining their protonation constants in different environments and their interactions with surrounding molecules is crucial to unraveling the complexity of biological systems.

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Equilibria Studies on Nickel(II) Complexes with 1,10-Phenanthroline Derivatives and Some Amino Acids in Aqueous Solution

Cited by 6 publications

References 48 publications

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

A comprehensive study on synthesis and crystal structures of Cu(II) and Ni(II) complexes: In vitro and in silico evaluation of biomolecular interactions, antiproliferative activities and molecular docking

Protonation constants of endo- and exogenous L-amino acids and their derivatives in aqueous and mixed solution: Unraveling molecular secrets

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