Equal induction and persistence of chromosome aberrations involving chromosomes 1, 4 and 10 in thyroid cancer patients treated with radioactive iodine

Puerto, S.; Marcos, Ricard; Ramírez, María-José; Galofré, Pere; Creus, A.; Surrallés, Jordi

doi:10.1016/s1383-5718(00)00064-4

Cited by 26 publications

(14 citation statements)

References 55 publications

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“…Therefore, it is important to allow for recovery of bone marrow between 131 I treatments. In support of these clinical observations, 131 I has been shown in peripheral lymphocytes to induce a significant increase in the number of dicentric chromosomes (275)(276)(277), and the aberrations of chromosomes 1, 4, and 10 are not only more prevalent but are still apparent after 4 years (276). A recent report comparing thyroid hormone withdrawal to rhTSH suggests a lower frequency of lymphocyte chromosomal rearrangements after 131 I dosing using rhTSH preparation (278).…”

Section: Recommendation Rating: Bmentioning

confidence: 76%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

966

1,365

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Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. Methods: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects £ 18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. Results: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

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Section: Recommendation Rating: Bmentioning

confidence: 76%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

966

1,365

View full text Add to dashboard Cite

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“…Ionizing radiation also acts directly on nuclear DNA and may result in single-or double-strand breaks (Calegaro, 2007). Previous studies assessed the impact of various doses of radioiodine in several systems and indicated that isotope exposure increases the frequency of chromosomal aberrations (Puerto et al, 2000;da Silva et al, 2008;Düsman et al, 2011) and micronuclei (MN) (Watanabe et al, 2004;Joseph et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro

Almeida

Düsman²,

Heck³

et al. 2013

Genet. Mol. Res.

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“…Studies conducted in several test systems with various doses of radioiodine, different than those tested here, showed high frequencies of chromosomal aberrations (Puerto et al 2000;Silva et al 2008) and micronuclei (Ballardin et al 2002;Watanabe et al 2004;Grawé et al 2005;Joseph et al 2009). The chromosomal damage induced by radioiodine exposure predisposes individuals to a future risk of developing cancer (Federico et al 2008).…”

Section: Introductionmentioning

confidence: 55%

“…Radioactive iodine, mainly iodine-131 ( 131 I), is a major source of human exposure to ionizing radiation (Puerto et al 2000). 131 I is used in the diagnosis of thyroidal dysfunctions and for the treatment of hyperthyroidism and differentiated thyroid cancer (Thrall and Ziessman 2003).…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats

Düsman

Berti

Mariucci

et al. 2011

Radiat Environ Biophys

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Iodine-131 ((131)I) is a radioisotope used for the diagnosis and treatment of thyroidal disorders such as hyperthyroidism and cancer. During its decay, (131)I emits beta particles and gamma rays; its physical half-life is 8 days, and it is accumulated preferentially in the thyroid tissue. This study aimed to evaluate the cytotoxicity and mutagenicity of diagnostic and therapeutic doses of (131)I using bone marrow cells of rats treated in vivo in a test system with a single dose by gavage. Concentrations of 5, 25, 50 and 250 μCi in 1 ml of water were used, and after 24 h, the animals were killed. Also, a concentration of 25 μCi/ml of water was used, and the animals were killed after 5 days. The results showed that no concentration of (131)I was cytotoxic and that all concentrations were mutagenic. As a result, there was no statistically significant difference detected by the χ(2) test in the induction of chromosomal aberrations between the different doses. Thus, the present study demonstrated a significant increase in chromosomal aberration in bone marrow cells exposed to (131)I regardless of the dose or the treatment time.

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Equal induction and persistence of chromosome aberrations involving chromosomes 1, 4 and 10 in thyroid cancer patients treated with radioactive iodine

Cited by 26 publications

References 55 publications

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro

Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats

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