Epstein‐Barr virus‐associated primary central nervous system cytotoxic T‐cell lymphoma

Abstract

Primary central nervous system lymphoma (PCNSL) expressing T-cell markers is rare, among which nasal-type extranodal NK/T-cell lymphoma is an extremely rare subtype associated with Epstein-Barr virus (EBV) infection. Here we report the clinicopathologic features of a case of EBV-associated PCNSL showing a cytotoxic T-cell phenotype. The patient, a 73-year-old woman, presented with rapidly progressive mental deterioration. Brain MRI revealed multiple lesions with swelling in the bilateral cerebral hemispheres, which were hypointense on T1-weighted images, hyperintense on T2-weighted and fluid-attenuated inversion recovery images, and slightly hyperintense on diffusion-weighted images. Biopsy specimens from the temporal region showed many medium-sized anaplastic lymphocytic cells with perivascular and angio-invasive patterns in the cortex. Immunohistochemically, the cells were positive for CD3, CD8, T-cell-restricted intracellular antigen-1 (TIA-1), granzyme B and perforin, but negative for CD56 and CD20. In situ hybridization revealed EBV-encoded RNAs in the tumor cell nuclei. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with a clonal appearance. The patient died 6 months after surgery, and a general autopsy revealed no lymphoma cells outside the brain. These cellular profiles are inconsistent with those of extranodal NK/T-cell lymphoma, and have not been previously described. This case appears to represent an unusual CNS manifestation of EBV-associated T-cell lymphoma.

Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas

“…Histopathological examination was performed on 4‐μm‐thick sections stained with HE. The paraffin‐embedded sections were processed for immunohistochemistry using methods previously described . Primary monoclonal antibodies against the following antigens were used: human IDH1 R132H (clone H09; Dianova, Hamburg, Germany; dilution 1:100), MGMT (clone MT3.1; Chemicon International, Temecula, CA, USA; 1:50), and human p53 (clone DO‐7; Dako, Glostrup, Denmark; 1:50).…”

Primary Central Nervous System Cytotoxic T-cell Lymphoma Mimicking Demyelinating Disease

“…The detection of cytoplasmic granuleassociated proteins, such as granzyme B and perforin, indicated that this T-cell lymphoma had a cytotoxic phenotype. To our knowledge, only a few previous cases of primary CNS cytotoxic T-cell lymphoma have been reported (6,7). This is a rare phenotype that may be associated with more pronounced necrosis and infiltration of macrophages than lymphoma cells.…”

Clinicopathological analysis of primary central nervous system NK/T cell lymphoma: rare and localized aggressive tumour among extranasal NK/T cell tumours

“…A total of 10 cases were collected from case reports in the English language literature (Table ) and analysed . There were nine IC cases and one IS case that was infected with HIV.…”

“…according to the 2008 World Health Organization (WHO) classification . Moreover, published case reports were reviewed, and 10 additional cases were selected for further analysis . The clinical and pathological information was obtained from a review of the papers.…”