Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis

Borkosky, Silvia Susana; Whitley, Corinna; Kopp‐Schneider, Annette; Hausen, Harald zur; E, Devilliers

doi:10.1371/journal.pone.0032160

Cited by 47 publications

(44 citation statements)

References 98 publications

(144 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This advocates a helper effect of EBV infections in the replication of TTV. Both the viruses might have a positive interaction in etiology and multiple sclerosis progression [149].…”

Section: Epstein Bar Virus As Helper Virus For Ttvmentioning

confidence: 99%

Current and Future Prospects of Torque Teno Virus

Elsaie¹

2013

J Vaccines Vaccin

View full text Add to dashboard Cite

Human health has a significant importance and it is directly affected by a number of factors like different diseases including microbial and viral infections. Up till now we have paid attention to the disease causing viruses and pathogens and less has been investigated about the usefulness of normal viral flora. One such orphan virus is Torque Teno Virus (TTV). The virus is present in healthy as well as diseased population, indicating its high prevalence. The virus is ubiquitous to human body as it is present in almost all tissues and organs and this is the property that can be utilized for targeted drug delivery. Another potentially useful property of this virus is TTV derived Apoptosis Inducing protein that can be a hope for the affectees.

show abstract

“…This advocates a helper effect of EBV infections in the replication of TTV. Both the viruses might have a positive interaction in etiology and multiple sclerosis progression [149].…”

Section: Epstein Bar Virus As Helper Virus For Ttvmentioning

confidence: 99%

Current and Future Prospects of Torque Teno Virus

Elsaie¹

2013

J Vaccines Vaccin

View full text Add to dashboard Cite

show abstract

“…Several pathogenic candidates have been proposed: Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), human cytomegalovirus (CMV), herpes simplex viruses (HSV) type 1 and 2, human endogenous retrovirus (HERV), measles virus (MeV), or even nonpathogenic torque teno virus (TTV) (Pender and Burrows 2014;Borkosky et al 2012;Zawada 2012;Zivadinov et al 2006;Swanborg et al 2003;Sanders et al 1996;Norrby et al 1974). Among bacteria, Pseudomonas aeruginosa has been postulated to be involved in MS pathogenesis, as it was shown by Hughes et al (2001) that specific antibodies are higher in MS patients than in controls.…”

Section: Introductionmentioning

confidence: 99%

Metagenomic Analysis of Cerebrospinal Fluid from Patients with Multiple Sclerosis

Perlejewski

Bukowska-Ośko

Nakamura

et al. 2016

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system of unknown etiology. However, some infectious agents have been suggested to play a significant role in its pathogenesis. Next-generation sequencing (NGS) and metagenomics can be employed to characterize microbiome of MS patients and to identify potential causative pathogens. In this study, 12 patients with idiopathic inflammatory demyelinating disorders (IIDD) of the central nervous system were studied: one patient had clinically isolated syndrome, one patient had recurrent optic neuritis, and ten patients had multiple sclerosis (MS). In addition, there was one patient with other non-inflammatory neurological disease. Cerebrospinal fluid (CSF) was sampled from all patients. RNA was extracted from CSF and subjected to a single-primer isothermal amplification followed by NGS and comprehensive data analysis. Altogether 441,608,474 reads were obtained and mapped using blastn. In a CSF sample from the patient with clinically isolated syndrome, 11 varicella-zoster virus reads were found. Other than that similar bacterial, fungal, parasitic, and protozoan reads were identified in all samples, indicating a common presence of contamination in metagenomics. In conclusion, we identified varicella zoster virus sequences in one out of the 12 patients with IIDD, which suggests that this virus could be occasionally related to the MS pathogenesis. A widespread bacterial contamination seems inherent to NGS and complicates the interpretation of results.

show abstract

“…A helper effect for the replication of single-stranded DNA viruses (eg, adenoassociated viruses by adeno-or herpes-type viruses or anelloviruses by EBV-producing cells) has been studied intensively. [101][102][103] Human cytomegalovirus permits the replication of adeno-associated viruses 104 and of JC polyomavirus in human fibroblasts, otherwise non-permissive for the latter. 105 Even vaccinia viruses replicating in the cytoplasm of infected cells provide a helper function for human adeno-associated virus type 5.…”

Section: Virus/virus Interactions In Carcinogenesismentioning

confidence: 99%

“…124,125 It is noteworthy that TT-virus-like particles have been reported in EBV-producing cell lines. 103,126 Nasopharyngeal carcinoma cells regularly contain EBV DNA. The geographic epidemiology of this tumor differs substantially from Burkitt lymphoma.…”

Section: Adeno-sv40 Hybrid Virusesmentioning

confidence: 99%