Current and Future Prospects of Torque Teno Virus

Elsaie, Mohamed L.

doi:10.4172/2157-7560.s1-004

Cited by 14 publications

(15 citation statements)

References 69 publications

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“…This study found no statistically significant difference between TTV positive and TTV negative individuals regarding the level of AST, ALT, other laboratory and ultrasonography finding which agree with study of Bostan et al [30], but contrary to other studies [8,31]. Rocchi et al [32] attributed the pathologic role of TTV to the capability of some isolates to activate production of pro-inflammatory cytokines, thus accelerate the severity of inflammatory disorders.…”

Section: Discussionsupporting

confidence: 84%

Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

sayed

Hamid²,

ElBadrawy³

et al. 2019

int. arab. j antimicrob. agents

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Background: SEN virus (SENV) and Torque teno virus (TTV) are blood born viruses. Their effect on the development and progress of liver diseases is still unclear. The aim of this study was to determine the prevalence and effect of SENV and TTV among chronic hepatitis C (CHC) patients. Patients and Methods: two hundred patients with CHC were the subjects of this work. A single blood sample was collected from each patient. Thorough clinical examination and relevant laboratory and radiological investigations were done. SENV and TTV were tested for by polymerase chain reaction (PCR). Results: SENV was identified in 3 and TTV was found in 21 (10.5%) of patients. No statistically significant difference was detected as regards clinical status, laboratory findings or radiological examination between SENV or TTV positive and negative patients. Conclusion: SENV and TTV exist among CHC patients. They had insignificant implications on the course or progression of liver diseases.

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Section: Discussionsupporting

confidence: 84%

Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

sayed

Hamid²,

ElBadrawy³

et al. 2019

int. arab. j antimicrob. agents

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“…There are at least 41 species infecting humans that are recognized by the ICTV based on the ORF1 region [ 46 ]. Some viruses, such as TTV 1, 12, 13, 16, SEN virus D and H, have been considered potential causal agents of hepatitis [ 14 , 48 – 50 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology

et al. 2017

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Hepatitis is a general term meaning inflammation of the liver, which can be caused by a variety of viruses. However, a substantial number of cases remain with unknown aetiology. We analysed the serum of patients with clinical signs of hepatitis using a metagenomics approach to characterize their viral species composition. Four pools of patients with hepatitis without identified aetiological agents were evaluated. Additionally, one pool of patients with hepatitis E (HEV) and pools of healthy volunteers were included as controls. A high diversity of anelloviruses, including novel sequences, was found in pools from patients with hepatitis of unknown aetiology. Moreover, viruses recently associated with gastroenteritis as sapovirus GV.2 and astrovirus VA3 were also detected only in those pools. Besides, most of the HEV genome was recovered from the HEV pool. Finally, GB virus C and human endogenous retrovirus were found in the HEV and healthy pools. Our study provides an overview of the virome in serum from hepatitis patients suggesting a potential role of these viruses not previously described in cases of hepatitis. However, further epidemiologic studies are necessary to confirm their contribution to the development of hepatitis.

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“…As such, TTV is globally prevalent and has often been noticed in the blood of even healthy individuals in a very high proportion [17,21]. Firstly a high prevalence rate and secondly the highly heterogeneous nature of its DNA have raised a serious concern.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is not clear whether these variants have some biological or pathogenic differences also [15]. Of course, few recent reports point to an association between genotypes/genogroups and the type of disease caused [17,18]. This needs further extensive investigation.…”

Section: Introductionmentioning

confidence: 99%

Development of an Immunoassay for Detection of Torque Teno Virus (TTV) Antibodies Using the N22 Expression Product from TTV Genotype 2

Mankotia

Irshad²

2017

Intervirology

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Aims: This study describes an immunoassay to detect anti-torque teno virus (TTV) antibodies using a peptide obtained from expression of the N22 region of TTV genotype 2. Methods: The N22 region (∼500 bp) of TTV genotype 2 was cloned in a pET-28a(+) vector and expressed in ZYM-5052 autoinduction medium. Following metal affinity chromatography, a purified polypeptide was used as an antigen for the development of an immunoassay to detect anti-TTV antibodies in human sera. Results: Recombinant protein (∼25-kDa) was obtained after 24 h of incubation at 25°C in ZYM-5052 autoinduction medium. A blot assay developed using this polypeptide as an antigen and TTV-positive sera as the primary antibody produced a distinct spot on the nitrocellulose membrane. Serum samples from 36 of 42 patients with renal disease and 29 of 48 patients with liver diseases produced a positive signal using this immunoassay. Simultaneously, 18 of 48 healthy controls were also detected to be positive for anti-TTV antibodies. These results were found to be comparable with TTV detection using PCR, and the assay showed a high sensitivity and specificity (i.e., 97.44 and 91.67%, respectively). Moreover, this assay could detect TTV infection irrespectively of the genotype, including cases of mixed infection. Conclusion: The present immunoassay using the N22 expression product may be used as an alternative to PCR to detect TTV infection in large populations.

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Current and Future Prospects of Torque Teno Virus

Cited by 14 publications

References 69 publications

Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology

Development of an Immunoassay for Detection of Torque Teno Virus (TTV) Antibodies Using the N22 Expression Product from TTV Genotype 2

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