Prevalence and Clinical Significance of SEN-virus and TT- virus Infection in Chronic HCV Patients

Abstract

Background: SEN virus (SENV) and Torque teno virus (TTV) are blood born viruses. Their effect on the development and progress of liver diseases is still unclear. The aim of this study was to determine the prevalence and effect of SENV and TTV among chronic hepatitis C (CHC) patients.
 Patients and Methods: two hundred patients with CHC were the subjects of this work. A single blood sample was collected from each patient. Thorough clinical examination and relevant laboratory and radiological investigations were done. SENV and TTV were tested for by polymerase chain reaction (PCR).
 Results: SENV was identified in 3 and TTV was found in 21 (10.5%) of patients. No statistically significant difference was detected as regards clinical status, laboratory findings or radiological examination between SENV or TTV positive and negative patients.
 Conclusion: SENV and TTV exist among CHC patients. They had insignificant implications on the course or progression of liver diseases.
 

Phylogenetic and molecular evolutionary analysis of SENV DNA isolated from Iraqi Hepatitis Patients

“…To date, five hepatitis viruses have been discovered, ranging from A to E, accounting for 80% to 90% of hepatitis cases. However, none of the hepatitis viruses were found in the remaining 10% to 20% of cases with classic viral hepatitis symptoms, indicating that other viruses, such as SENV, are likely to play a role in the pathogenesis of non-A-E hepatitis 3,13 .…”

“…Epidemiological studies have evidenced wide ranges of SENV in other pathological conditions, such as autoimmune diseases, respiratory conditions, cancer, thalassemia patients and patients on maintenance hemodialysis. In spite of several studies, the pathogenetic role of SENV has not yet been clarified [10][11][12][13] . The current study aims to detect the genetic changes in SEN-V and/or similarities between isolates in hepatitis patients.…”