Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis

Richardo, Timmy; Prattapong, Pongphol; Ngernsombat, Chawalit; Wisetyaningsih, Nurulfitri; Iizasa, Hisashi; Yoshiyama, Hironori; Janvilisri, Tavan

doi:10.3390/cancers12092441

Cited by 32 publications

(40 citation statements)

References 198 publications

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“…The EBV-encoded microRNAs that can activate invasion and metastasis of NPC cells include miR-BART6-3p, miR-BART7-3p, miR-BART8-3p, miR-BART9, miR-BART13, and miR-18-5p [88].…”

Section: Epstein-barr Virus (Ebv) Infection and Npc Metastasismentioning

confidence: 99%

Metastasis of nasopharyngeal carcinoma: What we know and do not know

et al. 2021

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Nasopharyngeal carcinoma (NPC) has the highest metastatic rate among head and neck cancers, with its underlying mechanism not yet fully unveiled. High- versus low-metastasis, NPC cell lines have been established. The footpad-popliteal lymph node metastasis model and other in vivo models have been stably used to study NPC metastasis. The histological appearance and the expression of epithelial-to-mesenchymal transition (EMT) markers might be helpful in selecting high-risk NPC patients for developing post-treatment metastasis. Tested EMT markers and their protein expression levels that correlate with patient disease-free survival in large patient cohorts include E-cadherin, N-cadherin, CD44, Twist, Snail, and Cyclin D1. Epstein-Barr virus (EBV) infection can trigger NPC metastasis from multiple angles via multiple signaling pathways. High endothelial venules are commonly seen in NPC tissues, with their role in NPC metastasis requiring clarification. The molecules that promote and inhibit NPC metastasis are introduced, with a focus on cytokines SPINK6, serglycin, interleukin 8 (IL8), Wnt family member 5A (WNT5A), and chemokine C-C motif ligand 2 (CCL2). Two videos showing NPC cells with and without SPINK6 knocked down are presented. Future directions for studying NPC metastasis are also discussed.

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“…The EBV-encoded microRNAs that can activate invasion and metastasis of NPC cells include miR-BART6-3p, miR-BART7-3p, miR-BART8-3p, miR-BART9, miR-BART13, and miR-18-5p [88].…”

Section: Epstein-barr Virus (Ebv) Infection and Npc Metastasismentioning

confidence: 99%

Metastasis of nasopharyngeal carcinoma: What we know and do not know

et al. 2021

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“…The tendency of the NPC incidence rate is specific to certain ethnic and geographic populations, especially in Southern China and Southeast Asia including Thailand [ 1 , 2 ]. A number of factors play a role in the onset of disease, such as salted-preserved food consumption [ 3 ], alcohol consumption, tobacco smoking [ 4 ], and Epstein–Barr virus (EBV) infection, and they also contribute to the progression of NPC [ 5 , 6 , 7 ]. NPC treatment is usually initiated by radiation, which is effective at the early stage [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma

et al. 2021

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Background: Members of the Wnt signaling pathway have been shown to play a role in nasopharyngeal carcinoma (NPC) progression. Aim: The purpose of this study was to investigate WNT8B protein expression in NPC patients using tissue microarray (TMA) analysis and to evaluate its correlation with patient survival and clinical parameters. Methods: A total of 82 NPC cases, together with six normal nasopharyngeal tissue samples, were targeted to construct the TMA blocks. The WNT8B protein expression was evaluated by immunohistochemistry and its correlation to the clinicopathological features was investigated. Results: Sixty-two of 82 (75.6%) cases exhibited high WNT8B protein expression while 20/82 (24.4%) cases appeared to have low WNT8B expression. The univariate analysis revealed that systemic metastasis was associated with patient 5-year survival. The multivariate Cox proportional hazard regression analysis showed that WNT8B expression and systemic metastasis were significantly associated with the survival of NPC patients. Furthermore, there was no correlation found between the WNT8B protein expression and other clinicopathological parameters. Conclusion: Our results suggest that the expression of WNT8B is associated with NPC patients’ survival and could serve as an independent prognostic factor for NPC patients.

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“…Nasopharyngeal carcinoma (NPC) is one of the distinctly distributional cancers and is geographically prevalent in southeast Asia and southern China (1). It is well known that Epstein-Barr virus (EBV) infection, host genetics, and environmental factors contribute to the occurrence of NPC, and EBV DNA testing is used to detect, prognose, and assess tumor response earlier (2,3).…”

Section: Introductionmentioning

confidence: 99%

Tumor Blood Flow Is a Predictor of Radiotherapy Response in Patients With Nasopharyngeal Carcinoma

Cao

Song

et al. 2021

Front. Oncol.

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PurposeThe aim of this study was to evaluate tumor blood flow (TBF) as a predictor of radiotherapy response for nasopharyngeal carcinoma (NPC).Materials and MethodA total of 134 patients were divided into two groups, the complete response (CR) group and the partial response (PR) group based on RECIST 1.1 recommendations. The statistical difference was evaluated for pre- and mid- or post-treatment TBF and changes of TBF for tumors and metastatic lymph nodes between CR and PR, respectively. The receiver operation characteristic (ROC) curve was utilized to evaluate the accuracy of TBF in predicting the response of radiation therapy. The association between TBF and SUVmax was also investigated.ResultsThe reduction of TBF in CR was significantly lower than that in PR for primary tumors (P <0.001) and metastatic lymph nodes (P <0.001). The multivariate logistic regression analysis indicated that the reduction of TBF is an independent predictor of the response of radiation therapy for primary tumors (P <0.001) and metastatic lymph nodes (P <0.001). The accuracy of TBF reduction in predicting the response of radiation therapy was 0.817 in primary tumors and 0.924 in metastatic lymph nodes, respectively. No significant correlation was observed between the TBF values and SUVmax of primary tumors (r = -0.008, P = 0.954) and metastasis lymph nodes (r = -0.061, P = 0.652).ConclusionThis study suggests that the reduction of TBF is a promising parameter for evaluating the response of radiation therapy.

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Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis

Cited by 32 publications

References 198 publications

Metastasis of nasopharyngeal carcinoma: What we know and do not know

Metastasis of nasopharyngeal carcinoma: What we know and do not know

WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma

Tumor Blood Flow Is a Predictor of Radiotherapy Response in Patients With Nasopharyngeal Carcinoma

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