Epstein-Barr-Virus-Infected CD15 (Lewis X)-Positive Hodgkin-Lymphoma-Like B Cells in Patients with Rheumatoid Arthritis

Inomata, H.; Takei, Masami; Nakamura, Hiroyuki; Fujiwara, Shigeyoshi; Shiraiwa, Hidetaka; Kitamura, Noboru; Hirohata, Shunsei; Masuda, Hiroyuki; Jin, Tao; Sawada, Shigemasa

doi:10.2174/1874312900903010041

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…They were also positive for Epstein-Barr nuclear antigen. Moreover, two EBV-positive B lymphoblastoid cell lines established using co-cultivated CD34+ cells isolated from the bone marrow of patients with RA and peripheral blood B lymphocytes from a healthy EBV-seronegative individual also expressed CD15 [14], thus indicating that EBV-infected B lymphoblastoid cells from patients with RA tend to acquire properties similar to those of HL cells [14].…”

Section: Discussionmentioning

confidence: 99%

Unusual B cell morphology in inflammatory bowel disease

Defendenti

Grosso

Atzeni

et al. 2012

Pathology - Research and Practice

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B lymphocytes express various different types of surface immunoglobulins that are largely unrelated to other hematological lines, although some reports have described a relationship between malignant B cells and other cells such as macrophages. Multiple genes of hematopoietic lineage, including transcription factors, are co-expressed in hematopoietic stem cells and progenitors, a phenomenon referred to as "lineage priming". Changes in the expression levels and timing of transcription factors can induce the lineage conversion of committed cells, which indicates that the regulation of transcription factors might be particularly critical for maintaining hierarchical hematopoietic development. The aim of this study was to evaluate the surface markers of particular IgM-positive and irregularly nucleated cells detected in patients with inflammatory bowel disease (IBD), and to assess their association with diagnosis and inflammatory cell recruitment. Small intestine, colon and rectal biopsy specimens of 96 IBD patients were studied. Immunoglobulin-producing cells (IPCs) were analyzed by means of immunofluorescence using polyclonal rabbit anti-human Ig and goat anti-human IgM. The specimens positive for B cells with irregular nuclei were assessed using monoclonal antibodies specific for CD79, and λ and κ chains in order to confirm their B cell nature. CD15+ cells, an important marker of inflammatory cell recruitment, were also evaluated. Statistical correlations were sought between the histological findings and clinical expression. 34 (35.4%) of the 96 patients (64 with ulcerative colitis and 32 with Crohn's disease) presented a periglandial localization of IPCs with irregular nuclei, which showed surface markers specific for the B cell subset, such as IgM and CD79, but quantitative differences in λ and κ chains. These specimens also contained CD15-positive cells, which are usually absent in healthy controls. The quantitative aspects and localization of the CD15-positive cells correlated with the distribution of the IPCs with irregular nuclei. IPCs with irregular nuclei were significantly more frequent in those patients with Crohn's disease than in those with ulcerative colitis (p<0.001). The finding of a subpopulation of cells that simultaneously showed irregular nuclei and B cell markers, such as functional surface IgM, in patients with IBD suggests that an unusual subgroup of B cells that correlates with CD15 expression and a diagnosis of Crohn's disease may be observed in the inflammatory process.

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Section: Discussionmentioning

confidence: 99%

Unusual B cell morphology in inflammatory bowel disease

Defendenti

Grosso

Atzeni

et al. 2012

Pathology - Research and Practice

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“…We examined a liver cancer mass spectrometry dataset 14,15 as an example to illustrate our methods. In this dataset, there are 202 participants from Cairo, Egypt: 73 hepatocellular carcinoma (denoted by HC) cases, 77 healthy individuals (denoted by NC) and 52 patients with chronic liver disease (denoted by QC).…”

Section: Examples 51 Liver Cancermentioning

confidence: 99%

“…Such results agree with earlier findings in the medical literature. 4,13,[15][16][17][18][19] The analysis based on PDI directly provided an order on the strength of synovial biomarkers in this example. In comparison, Ogdie et al 12 studied sensitivity, specificity and Youden index for pairwise two category analysis.…”

Section: Immunohistochemical Synovial Biomarkersmentioning

confidence: 99%

Nonparametric estimation and inference for polytomous discrimination index

Feng

Fine

et al. 2017

Stat Methods Med Res

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Polytomous discrimination index is a novel and important diagnostic accuracy measure for multi-category classification. After reconstructing its probabilistic definition, we propose a nonparametric approach to the estimation of polytomous discrimination index based on an empirical sample of biomarker values. In this paper, we provide the finite-sample and asymptotic properties of the proposed estimators and such analytic results may facilitate the statistical inference. Simulation studies are performed to examine the performance of the nonparametric estimators. Two real data examples are analysed to illustrate our methodology.

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Epstein-Barr-Virus-Infected CD15 (Lewis X)-Positive Hodgkin-Lymphoma-Like B Cells in Patients with Rheumatoid Arthritis

Cited by 2 publications

References 24 publications

Unusual B cell morphology in inflammatory bowel disease

Unusual B cell morphology in inflammatory bowel disease

Nonparametric estimation and inference for polytomous discrimination index

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