Epstein-Barr virus (EBV) infection and p53 protein expression in gastric carcinoma

Szkaradkiewicz, Andrzej; Majewski, Wacław; Wal, Marzena; Czyżak, Mirosław; Majewski, Przemysław; Bierła, Joanna B.; Kuch, Alicja

doi:10.1016/j.virusres.2005.12.001

Cited by 12 publications

(11 citation statements)

References 25 publications

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“…The present study shows the highest frequency of p53 mutation in the groups with H pylori infection, especially among the cagA+ cases, corroborating previous studies [16,3,4] . The high percentage of p53 mutation in EBV-associated and EBV-negative gastric carcinomas was observed in our study which was also demonstrated in other studies, demonstrating that the p53 mutation is a relevant alteration in gastric carcinogenesis independent of the infection [15,16,43] . Finally, this study shows the high prevalence of H pylori infection in gastric carcinomas in Ceará State.…”

Section: Discussionsupporting

confidence: 90%

“…Some of these, like c-Myc, p53 and the apoptotic family members such as Bcl-2 and Bax, deserve attention for playing a key function in the cell proliferation and cell fate, besides they already have shown involvement in the tumorigenesis process in a variety of tumors, including gastric cancer [11][12][13] . Although the proteins mentioned above have different levels of alteration in gastric carcinoma, the association with H pylori or EBV is controversial [14][15][16] . Additionally, there is just one paper related H pylori and EBV infection with concomitant analysis, in gastric carcinomas, in which, proteins involved in cell cycle and apoptosis process were also evaluated [10] .…”

Section: Introductionmentioning

confidence: 99%

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H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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AIM: To investigate the interrelationship betweenH pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression.METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS:The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P = 0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori .However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION:The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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“…In B-cell malignancies, where p53 mutations have been reported at 10 to 40%, abnormalities in p53 are associated with poor prognosis and reduced response to therapy [15,16]. A correlation between p53 protein expression and clinical effect could be evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance

Chen

Pang

et al. 2009

IJMS

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To study expression of CD40 and CD40L in gastric cancer tissue we assessed gastric cancer patients admitted to the Department of Gastroenterology of The First Affiliated Hospital of Soochow University and control subjects. Gastric cancer and normal (from around tumours) tissue samples were obtained from patients. Venous blood samples (gastric cancer and ulcer groups) were drawn on the morning of the day before surgery for the measurement of peripheral sCD40L. The expression of CD40 in gastric carcinoma specimens was examined immuno-histochemically. The clinicopathological factors, including age, sex, tumor size, gross appearance, degree of cellular differentiation, histological classification, depth of tumor invasion, lymph node metastasis, peritoneal dissemination, and TNM stage were analyzed according to the different expression of CD40. The results indicated a high CD40 expression in gastric cancer tissues. This positive expression of CD40 revealed a significant (P < 0.05) correlation with lymphatic metastasis and tumor TNM stage in gastric cancer patients. It is concluded that higher CD40 expression existed in expanding type tumors and could play an important role in clinical diagnosis of gastric cancer patients.

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“…Seventeen studies determined the presence of a TP53 expression in EBVaGC by performing immunohistochemistry. 14,21,24,26,27,31,32,48,54,[60][61][62][63][64][65][66][67] A TP53 expression was observed in 149 (36.2%) of 412 EBVaGC and in 717 (47.9%) of 1496 EBV-negative carcinomas. While statistical heterogeneity was found among the studies (Q = 36.368, d.f.…”

Section: Tp53 Expression and P53 Mutationmentioning

confidence: 99%

Clinicopathological and molecular characteristics of Epstein–Barr virus‐associated gastric carcinoma: A meta‐analysis

Lee

Kim

Han

et al. 2009

J of Gastro and Hepatol

218

188

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There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta-analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta-analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8%, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator-high status, but not with Helicobacter pylori infection, a TP53 expression, and p53 mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.

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Epstein-Barr virus (EBV) infection and p53 protein expression in gastric carcinoma

Cited by 12 publications

References 25 publications

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance

Clinicopathological and molecular characteristics of Epstein–Barr virus‐associated gastric carcinoma: A meta‐analysis

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