Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance

Abstract

To study expression of CD40 and CD40L in gastric cancer tissue we assessed gastric cancer patients admitted to the Department of Gastroenterology of The First Affiliated Hospital of Soochow University and control subjects. Gastric cancer and normal (from around tumours) tissue samples were obtained from patients. Venous blood samples (gastric cancer and ulcer groups) were drawn on the morning of the day before surgery for the measurement of peripheral sCD40L. The expression of CD40 in gastric carcinoma specimens was examined immuno-histochemically. The clinicopathological factors, including age, sex, tumor size, gross appearance, degree of cellular differentiation, histological classification, depth of tumor invasion, lymph node metastasis, peritoneal dissemination, and TNM stage were analyzed according to the different expression of CD40. The results indicated a high CD40 expression in gastric cancer tissues. This positive expression of CD40 revealed a significant (P < 0.05) correlation with lymphatic metastasis and tumor TNM stage in gastric cancer patients. It is concluded that higher CD40 expression existed in expanding type tumors and could play an important role in clinical diagnosis of gastric cancer patients.

Expression of the co-signaling molecules CD40-CD40L and their growth inhibitory effect on pancreatic cancer in vitro

“…Our previous study demonstrated that higher sCD40L was also detected in patients with gastric cancers than in healthy controls (13). Moreover, higher sCD40L was correlated with tumor metastasis and progression (13).…”

“…It has been reported that CD40-CD40L axis was involved in a series of cell biological activities, such as cancer, cardiovascular disease, immune disorders, and even Alzheimer's disease (9)(10)(11). CD40 was found to be expressed at an up-regulated level in many epithelial cancers (12)(13)(14)(15). Expression of CD40 and CD40L in gastric cancer tissue was positively correlated with lymphatic metastasis and tumor TNM stage (13).…”

“…CD40 was found to be expressed at an up-regulated level in many epithelial cancers (12)(13)(14)(15). Expression of CD40 and CD40L in gastric cancer tissue was positively correlated with lymphatic metastasis and tumor TNM stage (13). In mouse renal cancer cells, CD40 induced cell killing effect by activating Fas (12).…”

“…The plasmic staining was also considered as a positive signal. The positivity was expressed by a quantitative evaluation based on 3 parameters (13,19) …”

Sensitivity of Gastric Cancer Cells to Chemotherapy Drugs in Elderly Patients and Its Correlation with Cyclooxygenase-2 Expression

“…Its prognosis is poorer and 5-year survival rate is only 15%~20% (Li et al, 2015). The study demonstrated that adjuvant chemotherapy for gastric cancer after surgery, especially for advanced gastric cancer, could effectively remove micrometastases and ameliorate the patients' prognosis (Basaran et al, 2015).…”