Epstein-Barr virus-associated T-cell lymphoma in solid organ transplant recipients

Sivaraman, P.; Wc, Lye

doi:10.1016/s0753-3322(01)00081-6

Cited by 28 publications

(13 citation statements)

References 19 publications

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“…EBV has been found to infect a subset of T cells that express the viral receptor CD21. 4 High levels of uncontrolled viral replication are thought to facilitate the entrance of EBV into T cells. 5 Despite the presence of previous reports, which showed that EBV can infect T cells, in our study none of the seven assessable cases showed evidence of EBV infection in the T-cell population.…”

Section: Discussionmentioning

confidence: 99%

“…T-cell neoplasms constitute 10-15% of all post-transplant lymphoproliferative disorders and about 75% of T-cell post-transplant lymphoproliferative disorders have been shown to be negative for EBV and to behave more aggressively. [1][2][3][4][5] Posttransplant lymphoproliferative disorders harbouring both B-and T-cell clones in the same patient are extremely rare and there are only a few cases reported in the literature so far. [5][6][7][8][9][10][11][12][13] EBV plays an important role in driving the proliferation ( Table 1).…”

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confidence: 99%

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Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

et al. 2011

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As has been previously shown, the lack of immune surveillance plays a major role in the unchecked proliferation of Epstein-Barr virus (EBV)-infected B cells in the pathogenesis of B-cell post-transplant lymphoproliferative disorders. We hypothesised that the lack of immune surveillance should possibly also affect T cells, and this should lead to subsequent emergence of T-cell clones. The presence of both B-and T-cell clones in post-transplant lymphoproliferative disorders samples has rarely been demonstrated in the past. We systematically evaluated 26 B-cell post-transplant lymphoproliferative disorder, 23 human immune deficiency virus-associated B-cell lymphoma and 10 immune-competent diffuse large B-cell lymphoma samples for B-and T-cell clonality (polymerase chain reaction and heteroduplex analysis using BIOMED-2 protocol), T-cell subsets (immunohistochemistry) and EBV association (in situ hybridisation using EBER). One-half of B-cell posttransplant lymphoproliferative disorders showed evidence of monoclonal T-cell expansion, and among the T cells present in the tissue samples, CD8-positive cells predominated. Although 9/13 (69%) B-cell posttransplant lymphoproliferative disorders with the presence of monoclonal T-cell population had a CD4:CD8 ratio of r0.4, 0/13 of the cases without monoclonal T-cell expansion had a ratio r0.4 (P ¼ 0.002). Only 2/26 (8%) demonstrated significant cytological atypia in the CD3/CD8-positive cells. There was no association between EBV and presence of T-cell clones. T-cell clones were not identified in lymphomas other than B-cell post-transplant lymphoproliferative disorders. Among 53.8% cases of EBV-positive B-cell post-transplant lymphoproliferative disorders with associated clonal expansion of T-cells tested, none had EBV-positive T cells. We conclude that half of B-cell post-transplant lymphoproliferative disorders are associated with clonal expansion of CD8-positive T cells, most of which do not amount to the coexistence of a T-cell post-transplant lymphoproliferative disorders.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

et al. 2011

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“…These are more often seen in late-onset PTLDs and may simply represent sporadic lymphomas arising in immunocompromised patients [52,53]. A "hit and run" hypothesis for EBV has also been proposed [54].…”

Section: Ebv-negative Ptldmentioning

confidence: 99%

The post-transplant lymphoproliferative disorder?a literature review

Shroff

Rees

2004

Pediatric Nephrology

145

118

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The Epstein-Barr virus (EBV)-induced post-transplant lymphoproliferative disorder (PTLD) affects 1%-10% of all paediatric renal transplant recipients. This is a heterogeneous group of conditions characterised by EBV-driven proliferation of B-lymphocytes in the face of impaired T-cell immune surveillance. The risk factors predisposing to PTLD are becoming better understood, but its pathogenesis and myriad of clinical and histological features remain poorly defined. While new treatment modalities are being tried with variable success, regular EBV surveillance and carefully monitored reduction of immunosuppression remain the mainstay of treatment. In this review, we have presented the current knowledge of this increasingly common complication in renal transplant recipients.

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“…A similar feature of post-transplant T-cell proliferation and posttransplant B-cell proliferation is the predominant extranodal presentation [13]. Although EBV has been less frequently associated with post-transplant T-cell lymphoproliferative disorders, an aetiological role in the setting of immunosuppression has also been hypothesized [13,16,[18][19][20]. Antibodies to human T-cell leukaemia virus-1 (HTLV1) and human immunodeficiency viruses 1 and 2 (HIV1, HIV2) are not detected in the blood [21,22].…”

Section: Introductionmentioning

confidence: 99%