Epstein-Barr Virus–Associated Leiomyosarcoma of the Iris in a Child Infected With Human Immunodeficiency Virus

Tulvatana, Wasee; Pancharoen, Chitsanu; Mekmullica, Jutarat; Thisyakorn, Usa; Tinnungwattana, Uraiwan; Keetacheeva, Kanista; Shuangshoti, Shanop; Shuangshoti, Samruay

doi:10.1001/archopht.121.10.1478

Cited by 10 publications

(17 citation statements)

References 14 publications

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“…Patient 1 has been described elsewhere [9]. In brief, a 4-year-old girl with vertically acquired HIV infection presented with right eye pain and a whitish mass at the lower half of the iris.…”

Section: Case Reportsmentioning

confidence: 99%

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Suankratay¹,

Shuangshoti²,

Mutirangura³

et al. 2005

Clinical Infectious Diseases

143

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Section: Case Reportsmentioning

confidence: 99%

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Suankratay¹,

Shuangshoti²,

Mutirangura³

et al. 2005

Clinical Infectious Diseases

143

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“…Although several cases of iris leiomyosarcoma have been reported in the literature, only one was proved to have EBV-associated leiomyosarcoma by immunohistochemical studies [4,9]. Our patient is the second case report with immunohistochemically proven EBV associated iris leiomyosarcoma.…”

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 56%

“…However, leiomyosarcoma rarely occurs in the uveal tract. There has been only one case report of EBVassociated iris leiomyosarcoma in the English literature [4]. We are reporting another AIDS patient with EBV-associated iris leiomyosarcoma.…”

Section: Introductionmentioning

confidence: 80%

“…Iris leiomyosarcoma is an extremely rare malignant tumor [4][5][6]. It arises from the dilator and sphincter muscles, which are of neuroectoderm in origin.…”

Section: Commentmentioning

confidence: 99%

“…It arises from the dilator and sphincter muscles, which are of neuroectoderm in origin. Ebstein-Barr virus has been intimately associated, though not necessarily in a causal fashion, with multiple malignancies in AIDS including Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease, B-cell lymphomas [1], and leiomyosarcoma [4,5,7,8]. Although intraocular leiomyosarcoma has a potential to spread locally, it rarely metastasizes to distant organs resulting in an excellent survival prognosis [9].…”

Section: Commentmentioning

confidence: 99%

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Ebstein-Barr Virus-Associated Iris Leiomyosarcoma in an AIDS Patient : A Case Report

Rojnaporn¹

2014

J Clin Exp Ophthalmol

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Importance: Report of an AIDS patient with Ebstein-Barr virus (EBV)-associated iris leiomyosarcoma. Observations:A 19-year-old AIDS patient presented with a painless rapidly growing mass in the right iris. EBVassociated leiomyosarcoma was confirmed by an immunohistochemical study of the excisional biopsy. Conclusion:This is the second case report on immunohistochemically proven EBV-associated iris leiomyosarcoma in AIDS.

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Epstein–Barr virus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

et al. 2022

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We investigated the clinical features, treatment, and prognosis of laryngeal leiomyosarcoma (LLMS) and Epstein-Barr virus-associated (EBV-associated) LMS. We report a case of EBV-associated LLMS in an adult patient with HIV infection. We also conducted a review of the English-language literature on LLMS and EBV-associated leiomyosarcoma. To the best of our knowledge, 62 cases of LLMS and EBV-associated leiomyosarcoma have been reported to date. Of patients with LLS, 18.9% had distant metastases and 17.0% had local recurrence. The overall 5-year survival rate was 64.0%. Distant metastases affected the survival of patients with LLMS (p = 0.04). EBV-positive patients had a low survival rate (p = 0.01). Among patients with EBV-associated LMS, 8.2% had distant metastases and recurrence and the overall 5-year survival rate was 50.0%. EBV-associated LLMS is rare. The EBV infection might be a poor prognostic factor of LLMS.

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Epstein-Barr Virus–Associated Leiomyosarcoma of the Iris in a Child Infected With Human Immunodeficiency Virus

Cited by 10 publications

References 14 publications

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Ebstein-Barr Virus-Associated Iris Leiomyosarcoma in an AIDS Patient : A Case Report

Epstein–Barr virus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

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