Epstein-Barr virus—associated large granular lymphocyte leukemia with cutaneous infiltration

How I treat LGL leukemia

“…Various autoimmune diseases and viral infections may be associated with T-LGL leukemia; T-LGL leukemia has also been observed after organ or stem cell transplantation. [49][50][51][52][53][54] Very rarely, pulmonary artery hypertension has been observed. 48,55,56 In such cases, pulmonary vascular endothelial damage may result from cytotoxic activity of leukemic LGL through DAP10/DAP12 signaling.…”

Pathogenic Link Between Hydroa Vacciniforme and Epstein-Barr Virus–Associated Hematologic Disorders

“…Therefore, latent EBV infection might be associated with typical HV in other countries. However, patients with malignant lymphoma with severe HVlike eruptions have been reported exclusively in Asia, [13][14][15] Mexico, 16,17 and Peru, 18 whereas no specific epidemiologic distribution has been observed for typical HV. [1][2][3] The endemic occurrence of severe HV might be correlated with the prevalence of other EBV-associated NK/T-cell lymphomas in Asians and Latin Americans.…”

“…3 Latent EBV infection has been implicated in a variety of malignant conditions, including African Burkitt lymphoma, nasopharyngeal carcinoma, posttransplantation lymphoproliferative disorders, natural killer (NK)/T-cell lymphomas, chronic active EBV infection, gastric cancer, pyothorax-associated lymphoma, and smooth-muscle tumors. [4][5][6][7][8][9][10][11][12] Recently, in patients in Asia, [13][14][15] Mexico, 16,17 and Peru, 18 peculiar HV-like eruptions were found to progress to EBVassociated malignant lymphoma. Unlike typical HV, the eruptions became severe with age and were associated with facial swell-ing, indurated nodules on sun-protected as well as sunexposed areas, high-grade fever, and liver damage.…”

CD4+ T-Lymphocyte–Induced Epstein-Barr Virus Reactivation in a Patient With Severe Hypersensitivity to Mosquito Bites and Epstein-Barr Virus–Infected NK Cell Lymphocytosis

“…16 Especially, there have been several reports of patients with severe hydroa vacciniforme-like eruption, 16,21,22 characterized by recurrent necrotic papulovesicles in lightexposed and nonexposed areas. The patient in the present article also has shown hydroa vacciniforme-like eruption since she was 10 years old.…”