Epstein–Barr virus and thyroid cancer: The role of viral expressed proteins

Moghoofei, Mohsen; Mostafaei, Shayan; Nesaei, Abolfazl; Etemadi, Ashkan; Nahand, Javid Sadri; Mirzaei, Hamed; Rashidi, Bahman; Babaei, Farhad; Khodabandehlou, Niloofar

doi:10.1002/jcp.27144

Cited by 47 publications

(46 citation statements)

References 39 publications

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“…EBV‐encoded LMP1 is a functional homolog of the TNF‐receptor family and, through activating the NF‐κB, contributes to the oncogenic potential of EBV . Through microRNA microarray analysis, Cameron et al showed that EBV‐LMP1 dysregulates the different cellular miRNAs expression, including miR‐146a.…”

Section: Mir‐146a In Herpesvirusesmentioning

confidence: 99%

“…73 EBV-encoded LMP1 is a functional homolog of the TNF-receptor family and, through activating the NF-κB, contributes to the oncogenic potential of EBV. 132,133 Through microRNA microarray analysis, Cameron et al 61 showed that EBV-LMP1 dysregulates the different cellular miRNAs expression, including miR-146a. Examination of the miR-146a level in the EBV-latency type I and III BL line showed that miR-146a expression was significantly changed in latency type III cells (that express LMP1 protein), however, it was not significantly altered in latency type I cell lines.…”

Section: Mir-146a In Herpesvirusesmentioning

confidence: 99%

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The role of miR‐146a in viral infection

et al. 2019

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Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional regulation of cellular‐genes regulatory pathways. They also emerged as a significant regulator of the immune response. In particular, miR‐146a acts as an importance modulator of function and differentiation cells of the innate and adaptive immunity. It has been associated with disorder including cancer and viral infections. Given its significance in the regulation of key cellular processes, it is not surprising which virus infection have found ways to dysregulation of miRNAs. miR‐146a has been identified in exosomes (exosomal miR‐146a). After the exosomes release from donor cells, they are taken up by the recipient cell and probably the exosomal miR‐146a is able to modulate the antiviral response in the recipient cell and result in making them more susceptible to virus infection. In this review, we discuss recent reports regarding miR‐146a expression levels, target genes, function, and contributing role in the pathogenesis of the viral infection and provide a clue to develop the new therapeutic and preventive strategies for viral disease in the future.

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Section: Mir‐146a In Herpesvirusesmentioning

confidence: 99%

Section: Mir-146a In Herpesvirusesmentioning

confidence: 99%

The role of miR‐146a in viral infection

et al. 2019

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“…After the elimination of the triggering stimulus and the resolution of the injury, inflammation should be disabled in a programmed manner. However, if the stimulus is persistent, the acute inflammation becomes chronic in nature, and evidence suggests that chronic inflammation is strongly associated with cancer . About 20% of human cancers are associated with chronic inflammation caused by infectious agents, autoimmune diseases and long‐term exposure to irritants and other noxious agents.…”

Section: Introductionmentioning

confidence: 99%

“…However, if the stimulus is persistent, the acute inflammation becomes chronic in nature, and evidence suggests that chronic inflammation is strongly associated with cancer. 10,13,14 About 20% of human cancers are associated with chronic inflammation caused by infectious agents, autoimmune diseases and long-term exposure to irritants and other noxious agents. Common causes of persistent inflammation that lead to cancer development, include infection with hepatitis C or B viruses that lead to hepatocellular carcinoma, inflammatory bowel disease that leads to colorectal cancer and infection with Helicobacter pylori that leads to gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Nahand

Moghoofei

Salmaninejad

et al. 2019

Intl Journal of Cancer

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172

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Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of noncoding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological processes, including inflammatory pathways. Abnormal expression of miRNAs may be linked to the induction of inflammation that occurs in CC. Exosomes are a subset of extracellular vesicles shed by almost all types of cells, which can function as cargo transfer vehicles. Exosomes contain proteins and genetic material (including miRNAs) derived from their parent cells and can potentially affect recipient cells. Exosomes have recently been recognized to be involved in inflammatory processes and can also affect the immune response. In this review, we discuss the role of HPV proteins, miRNAs and exosomes in the inflammation associated with CC.

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“…При этом наиболее богата диморфными генами подъязычная железа. Более высокая экспрессия генов каналов хлорида и натрия в поднижнечелюстной железе самцов коррелирует с большей реабсорбцией NaCl [15].…”

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