“…Due to the fact that PID controllers cannot anticipate to the response of the patient and do not have any knowledge of the drug metabolism, stability problems are present. Therefore, strategies using adaptive (Haddad et al, 2003;Yelneedi et al, 2009;Dumont et al, 2009), predictive (Nunes et al, 2007;Ionescu et al, 2008;Nino et al, 2009) and bayesian-based (De Smet et al, 2008;Struys et al, 2004;Mortier et al, 1998) closed-loop control algorithms have been suggested. Most of these controllers use the Bispectral Index (BIS) signal as a feedback signal for control.…”