EPR Spin-Trapping Studies of the Hydroxyl Radical Scavenging Activity of Carnosine and Related Dipeptides

Chan, W.K.M.; Decker, Eric A.; Lee, Jin B.; Butterfield, D. A.

doi:10.1021/jf00043a003

Cited by 112 publications

(59 citation statements)

References 13 publications

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“…3 A, B). It was previously reported that carnosine and its related compounds quench hydroxyl radicals generated in the Fenton reaction (29,30). As the effects of carnosine and its related compounds on free radical generation by the ferritin/H2O2 system were examined in this study, when ferritin was incubated with H2O2 in the presence of carnosine, homocarnosine, or anserine at 37 o C, all compounds were shown to inhibit hydroxyl radical generation (Fig.…”

Section: Effects Of Carnosine and Related Compounds On The Ferritin/ mentioning

confidence: 66%

Reaction of ferritin with hydrogen peroxide induces lipid peroxidation

Yoon¹,

Lee²,

Kang³

2010

BMB Reports

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Lipid peroxidation is known to be an important factor in the pathologies of many diseases associated with oxidative stress. We assessed the lipid peroxidation induced by the reaction of ferritin with H2O2. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and H2O2, lipid peroxidation increased in the presence of ferritin and H2O2 in a concentration-dependent manner. The hydroxyl radical scavengers, azide and thiourea, prevented lipid peroxidation induced by the ferritin/H2O2 system. The iron specific chelator desferoxamine also prevented ferritin/H2O2 systemmediated lipid peroxidation. These results demonstrate the possible role of iron in ferritin/H2O2 system-mediated lipid peroxidation. Carnosine is involved in many cellular defense processes, including free radical detoxification. In this study, carnosine, homocarnosine, and anserine were shown to significantly prevent ferritin/H2O2 system-mediated lipid peroxidation and also inhibited the free radical-generation activity of ferritin. These results indicated that carnosine and related compounds may prevent ferritin/H2O2 system-mediated lipid peroxidation via free radical scavenging. [BMB reports 2010; 43(3): 219-224]

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Section: Effects Of Carnosine and Related Compounds On The Ferritin/ mentioning

confidence: 66%

Reaction of ferritin with hydrogen peroxide induces lipid peroxidation

Yoon¹,

Lee²,

Kang³

2010

BMB Reports

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show abstract

“…However, carnosine and related compounds have not been found to chelate iron in a manner that reduces its prooxidant activity (32). It has been reported that carnosine and related compounds quench 50-95% of hydroxyl radicals produced in the Fenton reaction (33). Therefore, it was suggested that the ability of carnosine and related compounds to inhibit ferritin/H2O2-mediated DNA damage was likely due to free radical scavenging activity.…”

Section: Resultsmentioning

confidence: 99%

Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage

Kang¹

2010

BMB Reports

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“…In general, ionizing radiation is still a highly effective therapeutic tool for different types of cancer and is, therefore, frequently employed. Since formation of ROS is one of the major reasons for cellular injury after radiation (Riley 1994), carnosine may protect healthy tissue from damage and inflammation due to its antioxidant (Babizhayev et al 1994;Chan et al 1994) or anti-inflammatory properties [for a review see (Nagai 1980)]. The hypothesis of Guney et al (2006) has not been tested in humans, but 20 years ago Severin et al (1990) reported that carnosine administered per os (50-200 mg/kg/day) during a period of 20 days prior to irradiation increased survival rates in albino mice subjected to whole-body X-irradiation (5.0 Gy).…”

Section: Positive Side Effectsmentioning

confidence: 99%

Carnosine and cancer: a perspective

Gaunitz

Hipkiss

2012

Amino Acids

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The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or b-alanine.

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EPR Spin-Trapping Studies of the Hydroxyl Radical Scavenging Activity of Carnosine and Related Dipeptides

Cited by 112 publications

References 13 publications

Reaction of ferritin with hydrogen peroxide induces lipid peroxidation

Reaction of ferritin with hydrogen peroxide induces lipid peroxidation

Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage

Carnosine and cancer: a perspective

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