Epoxycytochalasin H methanol solvate

Abstract

In the title solvate, C30H39NO5·CH4O {systematic name: 21-acet­oxy-18,21-dihy­droxy-5,6,16,18-tetra­methyl-10-phenyl-6,7-ep­oxy-[11]cytochalasa-13,19-dien-1-one methanol solvate}, the organic mol­ecule exhibits the tetra­cyclic terpenoid skeleton of cytochalasin, consisting of fused five-, six-, three- and 11-membered rings. The five-membered ring adopts an envelope conformation, while the six-membered ring is in a boat conformation. The ep­oxy O atom on the six-membered ring is pointing away from the five-membered ring. An inter­stitial methanol solvent mol­ecule is hydrogen bonded to the cytochalasin mol­ecules and inter­molecular O—H⋯O and N—H⋯O hydrogen bonds connect the mol­ecules into infinite chains along the (10) direction.