Epithelioid Hemangioma Versus Kimuraʼs Disease

Kimura Disease of the Epiglottis

“…Kimura disease (KD) is currently considered as a benign reactive chronic inflammatory disorder of unknown pathogenesis and of uncertain etiology [1][2][3][4][5]. For a relatively long period of time and especially in the West, it was considered as a late stage of angiolymphoid hyperplasia with esinophilia (ALHE) [5].…”

“…For a relatively long period of time and especially in the West, it was considered as a late stage of angiolymphoid hyperplasia with esinophilia (ALHE) [5]. The development of its concept and its separation from ALHE had undergone several changes, since its first description in the literature (Table 1) [1,3,[5][6][7][8]. KD typically presents as a tumor-like mass in the head and neck region [1][2][3].…”

“…A constant feature of KD is the pattern of esinophilic infiltrate. Esinophils are present in large numbers in the interfollicular septae, the perinodal stroma as well as the mantle zone and the germinal centers of the lymphoid follicles [2,[5][6][7]12]. Esinophilic microabscess formation with/without Charcot-Leyden crystals is another less frequent, but characteristic finding [7].…”

“…A very important histological differential diagnosis and pitfall to be avoided is ALHE. The important and helpful features differentiating KD from ALHE are summarized in (Table 2) [5,[7][8][9][10][11][12]. CD has characteristic ''onion-skin'' layering of the mantle zone with hyalinized blood vessels in the germinal centers.…”

Doença de Kimura não é hiperplasia angiolinfóide com eosinofilia: correlação clinicopatológica com revisão da literatura e definição de critérios diagnósticos

“…Fibroplasia cellularity varies and tends to hyalinization of older lesions. 13,21 The lesions are markedly of vascular type; capillaries are numerous and their endothelium is prominent and with no cytological atypias. 13,21 Small arteries present hyperplasia or fibrosis of tunica intima and tunica muscularis.…”