Epithelioid Angiosarcoma of the Adrenal Gland Associated with Chronic Arsenical Intoxication?

Livaditou, A; Alexiou, George Α.; Floros, D.; Filippidis, Theodoros; Dosios, T.; Bays, D.

doi:10.1016/s0344-0338(11)80785-5

Cited by 33 publications

(22 citation statements)

References 18 publications

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“…There is no known association between hypercortisolism and angiosarcoma development. Arsenic exposure has been implicated as a risk factor in angiosarcoma development in one study (12). In contrast to hepatic angiosarcoma, PAA has never been reported following vinyl chloride exposure.…”

Section: Discussionmentioning

confidence: 96%

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Lepoutre-Lussey

Rousseau²,

Ghuzlan³

et al. 2012

European Journal of Endocrinology

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Context: Primary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion. Clinical presentation and intervention: A 35-year-old man presented with hypokalemic hypertension leading to the discovery of a 6 cm diameter malignant-appearing right adrenal tumor. The lesion displayed marked 18 F-fluorodeoxyglucose uptake on positron emission tomography scanning. Endocrine investigations revealed secretion of both cortisol and aldosterone by the neoplasm. The entire right adrenal gland along with the periadrenal fat tissue was removed during laparoscopic surgery. Results: Histological examination revealed two intermingled tumor cell proliferations, namely an angiosarcoma and an adrenocortical adenoma. An extensive post-operative search revealed no other primary tumor site, nor metastases. The lesion was then considered to be a primary adrenal angiosarcoma combined with a secreting adrenocortical adenoma. The patient received four cycles of chemotherapy (adriamycin/ifosfamide). At 2-year follow-up, he is alive and well, with no sign of relapse. Conclusion: To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma.

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Section: Discussionmentioning

confidence: 96%

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Lepoutre-Lussey

Rousseau²,

Ghuzlan³

et al. 2012

European Journal of Endocrinology

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“…According to Rosen et al (1988), MeisKindblom and Kindblom (1998) and Deyrup et al (2009) (Kareti et al, 1988;Livatidou et al, 1991;Bosco et al, 1991;Wenig et al, 1994;Otal et al, 1999;Ben Izhak et al, 1999;Krüger et al, 2001;Croitoru et al, 2001;Invitti et al, 2001;Pasqual et al, 2002;Lepoutre-Lussey et al, 2012;Derlin et al, 2012).…”

Section: Review Discussion and Conclusionmentioning

confidence: 99%

Adrenal Gland Hemangiosarcoma in a Patient with Chronic Myeloid Leukaemia

Bacalja¹,

Ulamec²,

Rako³

et al. 2013

IJCRM

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Hemangiosarcomas are rare tumours, predominantly affecting adult and elderly patients. Most frequently they involve the skin, although they can occur in visceral organs and other tissues. Hemangiosarcomas pursue an aggressive clinical course with high mortality rates. Primary adrenal hemangiosarcoma is extremely rare. We report a case of a 64-year-old male patient. He underwent ultrasound and computed tomography scan because of pain in his left lumbar area present over the previous 2 months. Tumor mass of the adrenal gland was found and he underwent left adrenalectomy. Macroscopically, cystic tumor that measured up to 9 cm in diameter was found. Histological diagnosis was hemangiosarcoma. The patient was being treated for chronic myeloid leukaemia for 7 years. During the time the adrenal tumor was diagnosed, he had been in remission. He died one and a half months after tumor resection because of profound bleeding in postoperative area. To our knowledge, this is the first case of a primary adrenal gland hemangiosarcoma in a patient treated for chronic myeloid leukaemia.

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“…There is little information about its distribution, but it probably occurs in the same age group as other hemangiosarcomas (sixth and seventh decades of life) [6]. The most widely recognized predisposing factors in angiosarcoma involving other areas of the body include chronic lymphedema, anabolic steroid therapy, thorotrast, and familial angiodysplasia.…”

Section: Discussionmentioning

confidence: 99%

“…Occupational or environmental carcinogens such as vinyl chloride, arsenic, and copper have also been linked to the development of angiosarcoma [8]. The first correlation between chronic exposure to arsenic compounds and hemangiosarcomas was proposed in 1957, but the carcinogenic effect of arsenic on the adrenals was not reported until 1991, when Livaditou et al presented a case of epithelioid adrenal hemangiosarcoma, probably secondary to use of arsenic-containing insecticides [6]. In 1992, Ofer Ben-Izhak et al presented a case report of epithelioid adrenal hemangiosarcoma with associated mesenteric fibromatosis and an elevated serum level of estradiol [5].…”

Section: Discussionmentioning

confidence: 99%

Hemangiosarcoma of the adrenal glands: CT findings in two cases

et al. 2001

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Hemangiosarcomas of the adrenal gland, both benign and malignant, are exceedingly rare; only a dozen of them have been reported in literature to our knowledge. We describe herein the findings at CT of 2 primary hemangiosarcomas of the adrenal glands. We also discuss their etiology, incidence, and differential diagnosis, particularly in relation to more frequent primary adrenal lesions, such as adrenal adenomas and carcinomas. CT will generally show a heterogeneous mass with frequent necrosis, contrast-enhancement, and occasional calcifications. A prospective diagnosis cannot be made by imaging alone, and pathology represents the discriminating method for a correct diagnosis.Key words: Adrenal gland, neoplasms-Adrenal gland, computed tomography.Primary malignant neoplasms of the adrenal gland are uncommon and may involve the adrenal cortex (adenocarcinoma) or the adrenal medulla (pheochromocytoma and neuroblastoma) [1,2]. The adenocarcinoma is the most frequent primary malignant tumor of the adrenal gland. Vascular tumors of the adrenal gland, both benign and malignant, are exceedingly rare. The angiosarcoma probably represents approximately 1-2% of these tumors.Angiosarcomas occur in the skin, breast, retroperitoneum, and visceral organs, with the liver being the most frequent site of visceral organ involvement [3]. Only a dozen primary angiosarcomas of the adrenal gland have been reported in the literature to our knowledge [1, 4 -8], the first case being described in 1988 by Kareti et al.Metastatic involvement of the adrenals by angiosarcomas is much more frequent.We describe the computed tomographic (CT) findings of two primary hemangiosarcomas of the adrenal glands. We also discuss their etiology, incidence, and differential diagnosis, particularly in relation to more frequent primary adrenal lesions, such as adrenal adenomas and carcinomas. Case reports Case 1A 67-year-old male, without a significant medical history, presented with left flank pain of 6 months' duration. The patient exhibited no hematuria or hypertension. An intra-

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Epithelioid Angiosarcoma of the Adrenal Gland Associated with Chronic Arsenical Intoxication?

Cited by 33 publications

References 18 publications

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

Adrenal Gland Hemangiosarcoma in a Patient with Chronic Myeloid Leukaemia

Hemangiosarcoma of the adrenal glands: CT findings in two cases

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