Epithelio-mesenchymal transitional attributes in oral sub-mucous fibrosis

Das, Raunak Kumar; Anura, Anji; Pal, Mousumi; Bag, Swarnendu; Majumdar, Subhadipa; Barui, Ananya; Chakraborty, Chandan; Ray, Ajoy Kumar; Sengupta, Sanghamitra; Paul, Ranjan Rashmi; Chatterjee, Jyotirmoy

doi:10.1016/j.yexmp.2013.08.006

Cited by 50 publications

(49 citation statements)

References 47 publications

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“…S5 and Fig. 3; Table ST5) were corroborative with features of epithelial proliferation and migration (Shih et al, 2004;Das et al, 2013) as well as wound healing and regeneration (Pinho et al, 2009;Taniguchi et al, 1999;Yoshimura et al, 1996). The p63 expression was more intense under .1% dilution [ Fig.…”

Section: Discussionsupporting

confidence: 70%

“…One of such important marker is p63 which act as master regulator for cellular proliferation and maturation (Nair and Krishnan, 2013) whereas expression and distribution pattern of E-cadherin and β-catenin are crucial to restore cell-cell adhesion and re-epithelialization (Stockinger et al, 2001). Expressions of E-cadherin and β-catenin alter in different healing phases and particularly during proliferation they pre-dominantly become cytoplasmic (Shih et al, 2004;Das et al, 2013). Modulation in expressions of E-cadherin and β-catenin in different phases of healing is attributed to genes like N-acetylglucosaminyltransferase (GnT) III and N-acetylglucosaminyltransferase (GnT) V (Kitada et al, 2001).…”

mentioning

confidence: 99%

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Modulating prime molecular expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic honey dilutions

Chaudhary

Bag

Mandal

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 70%

mentioning

confidence: 99%

Modulating prime molecular expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic honey dilutions

Chaudhary

Bag

Mandal

et al. 2015

Journal of Ethnopharmacology

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“…Treatment of the cancer cells with transforming growth factor β could induce E-cadherin redistribution from the cell surface to cytoplasm without affecting the expression level [51]. In oral mucosa, E-cadherin redistribution from membrane to the cytoplasm is observed during EMT [52]. …”

Section: Potential Linkage Between E-cadherin and Microrna Networkmentioning

confidence: 99%

Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers: The Potential Interplay

Wong

Gao

Chan

2014

BioMed Research International

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E-cadherin expression in the head and neck epithelium is essential for the morphogenesis and homeostasis of epithelial tissues. The cadherin-mediated cell-cell contacts are required for the anchorage-dependent growth of epithelial cells. Further, survival and proliferation require physical tethering created by proper cell-cell adhesion. Otherwise, the squamous epithelial cells will undergo programmed cell death. Head and neck cancers can escape from anoikis and enter into the epithelial-mesenchymal transition stages via the modulation of E-cadherin expression with epigenetic mechanisms. At epigenetic level, gene expression control is not dependent on the DNA sequence. In the context of E-cadherin regulation in head and neck cancers, 2 major mechanisms including de novo promoter hypermethylation and microRNA dysregulation are most extensively studied. Both of them control E-cadherin expression at transcription level and subsequently hinder the overall E-cadherin protein level in the head and neck cancer cells. Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2.

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“…19,20 Recent studies have implicated p63 with EMT. Das et al 21 showed that fibrotic lesions in oral submucosa showed marked upregulation of p63 and Oh et al 22 showed that primary human keratinocytes transfected with ΔNp63 underwent EMT when they had depleted their normal proliferative capacity.…”

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Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture

Jónsdóttir

Arason

Pálsson

et al. 2015

Laboratory Investigation

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Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high morbidity and mortality. The cellular source of the fibrotic process is currently under debate with one suggested mechanism being epithelial-to-mesenchymal transition (EMT) in the alveolar region. In this study, we show that airway epithelium overlying fibroblastic foci in IPF contains a layer of p63-positive basal cells while lacking ciliated and goblet cells. This basal epithelium shows increased expression of CK14, Vimentin and N-cadherin while retaining E-cadherin. The underlying fibroblastic foci shows both E-and N-cadherin-positive cells. To determine if p63-positive basal cells were able to undergo EMT in culture, we treated VA10, a p63-positive basal cell line, with the serum replacement UltroserG. A sub-population of treated cells acquired a mesenchymal phenotype, including an E-to N-cadherin switch. After isolation, these cells portrayed a phenotype presenting major hallmarks of EMT (loss of epithelial markers, gain of mesenchymal markers, increased migration and anchorage-independent growth). This phenotypic switch was prevented in p63 knockdown (KD) cells. In conclusion, we show that airway epithelium overlying fibroblastic foci in IPF lacks its characteristic functional identity, shows increased reactivity of basal cells and acquisition of a partial EMT phenotype. This study suggests that some p63-positive basal cells are prone to phenotypic changes and could act as EMT progenitors in IPF.

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Epithelio-mesenchymal transitional attributes in oral sub-mucous fibrosis

Cited by 50 publications

References 47 publications

Modulating prime molecular expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic honey dilutions

Modulating prime molecular expressions and in vitro wound healing rate in keratinocyte (HaCaT) population under characteristic honey dilutions

Interactions between E-Cadherin and MicroRNA Deregulation in Head and Neck Cancers: The Potential Interplay

Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture

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