Epithelial maturation and molecular biology of oral HPV

Abstract

Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infection leading to benign, potentially malignant or malignant lesions. The HPV cycle is influenced by the stage of maturation of the infected keratinocytes, and the production of virions is restricted to the post-mitotic suprabasal epithelial cells where all the virus genes are expressed.Low-risk HPV genotypes are associated with the development of benign oral lesions, whereas high-risk HPV genotypes are implicated in the development of malignant epithelial neoplasms. The rôle of high-risk HPV as a causative agent in epithelial malignancy is different at different anatomical sites: it is almost invariably implicated in squamous cell carcinoma of the uterine cervix, fairly frequently implicated in squamous cell carcinoma of the oropharynx, and it is seldom implicated in squamous cell carcinoma of the mouth.

Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca

“…Se ha mencionado que estas células se localizan frecuentemente en el estrato espinoso, sin embargo, en este estudio estas células se observaron tanto en los estratos espinosos, como en los basales y parabasales, además el análisis estadístico no demostró su presencia en algún estrato en particular 19 . El VPH se caracteriza por su capacidad de inducir proliferación celular 20 , la hiperplasia epitelial, la hiperplasia pseudoepiteliomatosa, la hiperplasia basal y la papilomatosis, aunque predominan en alguno de los tres tipos de patologías no son criterios útiles por si mismos para diferenciar estas lesiones.…”

Infecção oral pelo HPV em mulheres com lesão escamosa de colo uterino no sistema prisional da cidade de São Paulo, Brasil

“…Sexual behavior has a direct relationship with the transmission mechanism of this viral infection, and the direct contact between the mucosae is the main route [4][5][6][7] . Vertical transmission can also happen 8,9 . HPV is a DNA virus, epitheliotropic, nonenveloped, with a double strand circular genome, and about 8,000 pb, measuring 55 nm in diameter.…”

Detection of Human Papillomavirus among Patients with Clinically Diagnosed Cutaneous Warts by PCR Method

“…HPV also has the capacity to stimulate cells to premalignant and malignant transformation [1]. HPVs are divided into mucosal and cutaneous types [2].…”